A5033144356- Pluripotent Stem Cells Research
- Neurogenesis and neuroplasticity mechanisms
- Axon Guidance and Neuronal Signaling
- CRISPR and Genetic Engineering
- Epigenetics and DNA Methylation
- Pancreatic function and diabetes
- RNA modifications and cancer
- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetic Syndromes and Imprinting
- Genetics, Aging, and Longevity in Model Organisms
- Microtubule and mitosis dynamics
- Adipose Tissue and Metabolism
- Genetics and Neurodevelopmental Disorders
- RNA Interference and Gene Delivery
- Metabolism and Genetic Disorders
- Trace Elements in Health
- Birth, Development, and Health
- Prion Diseases and Protein Misfolding
- Hippo pathway signaling and YAP/TAZ
University of Lausanne
2022-2024
Universitat de Barcelona
2018-2023
Instituto de Salud Carlos III
2018-2023
Biomedical Research Networking Center on Neurodegenerative Diseases
2018-2023
Centro de Investigación Biomédica en Red
2023
Columbia University
2022
Virologie et Immunologie Moléculaires
2015
Aging is the major risk factor for most human diseases and represents a socio-economical challenge modern societies. Despite its importance, process of aging remains poorly understood. Epigenetic dysregulation has been proposed as key driver process. Modifications in transcriptional networks chromatin structure might be central to age-related functional decline. A prevalent feature described during overall reduction heterochromatin, specifically marked by loss repressive histone...
The extracellular protein Reelin, expressed by Cajal-Retzius (CR) cells at early stages of cortical development and late GABAergic interneurons, regulates radial migration the "inside-out" pattern positioning. Current models Reelin functions in corticogenesis focus on CR cell-derived layer I. However, developmental disorders linked to deficits, such as schizophrenia autism, are related interneuron-derived although its role has not been established. Here we selectively inactivated Reln gene...
In addition to neuronal migration, brain development, and adult plasticity, the extracellular matrix protein Reelin has been extensively implicated in human psychiatric disorders such as schizophrenia, bipolar disorder, autism spectrum disorder. Moreover, heterozygous reeler mice exhibit features reminiscent of these disorders, while overexpression protects against its manifestation. However, how influences structure circuits striatal complex, a key region for above-mentioned is far from...
Axonal growth and guidance rely on correct cone responses to cues. Unlike the signaling cascades that link axonal cytoskeletal dynamics, little is known about crosstalk mechanisms between membrane dynamics turnover. Recent studies indicate whereas attraction requires exocytosis, chemorepulsion relies endocytosis. Indeed, our own have shown Netrin-1/Deleted in Colorectal Cancer (DCC) triggers exocytosis through SNARE Syntaxin-1 (STX1). However, limited vivo evidence available role of proteins...
The prion protein (PrP) binds to various molecular partners, but little is known about their potential impact on the pathogenesis of diseases Here, we show that PrP can interact in vitro with acetylcholinesterase (AChE), a key cholinergic system neural and non-neural tissues. This heterologous association induced aggregation monomeric modified structural properties amyloid fibrils. Following its recruitment into fibrils, AChE loses enzymatic activity enhances PrP-mediated cytotoxicity. Using...
SUMMARY The induction of cellular reprogramming by forced expression the transcription factors OCT4, SOX2, KLF4, and C-MYC (OSKM) has been shown to allow dedifferentiation somatic cells ameliorate age-associated phenotypes in multiple tissues organs. Yet date, benefits vivo are limited occurrence detrimental side-effects. Here, using complementary genetic approaches, we demonstrated that continuous leads hepatic intestinal dysfunction resulting decreased body weight premature death. By...
SUMMARY In the last decade, cellular reprogramming of fully differentiated cells to pluripotent stem has become great interest. Importantly, by expression Oct4, Sox2, Klf4, and cMyc (OSKM) can ameliorate age-associated phenotypes in multiple tissues extend lifespan progeroid aged wild-type mice. Surprisingly, effects vivo have not been deeply investigated any other model organisms. Here, for first time, we induce C. elegans using a heat-inducible system at developmental adult stages. Similar...
Abstract Age-associated neurodegenerative disorders represent significant challenges due to progressive neuronal decline and limited treatments. In aged mice, partial reprogramming, characterized by pulsed expression of reprogramming factors, has shown promise in improving function various tissues, but its impact on the aging brain remains poorly understood. Here we investigated vivo mature neurons dentate gyrus young mice. Using two different approaches – a neuron-specific transgenic...
<title>Abstract</title> Aging is the major risk factor for most human diseases and represents a socio-economical challenge modern societies. Despite its importance, process of aging remains poorly understood. Epigenetic dysregulation has been proposed as key driver process. Alterations in transcriptional networks chromatin structure might be central to age-related functional decline. A prevalent feature described during overall reduction heterochromatin, specifically marked by loss...
Abstract In addition to neuronal migration, brain development and adult plasticity, the extracellular matrix protein Reelin has been extensively implicated in human psychiatric disorders such as schizophrenia, bipolar disorder autistic spectrum disorder. Moreover, heterozygous reeler mice exhibit features reminiscent of these disorders, while overexpression protects against its manifestation. However, how influences structure circuits striatal complex, a key region for above-mentioned is far...