A5008022094- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Animal and Plant Science Education
- Parasitic infections in humans and animals
- Congenital Anomalies and Fetal Surgery
- Biochemical and Molecular Research
- Parasitic Infections and Diagnostics
- Insect Utilization and Effects
- Cancer therapeutics and mechanisms
- Antimicrobial Peptides and Activities
- Biosimilars and Bioanalytical Methods
- Insect and Arachnid Ecology and Behavior
- Phenothiazines and Benzothiazines Synthesis and Activities
- Metal Extraction and Bioleaching
Universidad Peruana Cayetano Heredia
2017-2023
St George's, University of London
2021
Centro de Investigación y Desarrollo
2019
Tuberculosis (TB) is a major global health problem and drug resistance compromises the efforts to control this disease. Pyrazinamide (PZA) an important used in both first second line treatment regimes. However, its complete mechanism of action remains unclear.
The gut microbiota of insects is composed a wide range microorganisms which produce bioactive compounds that protect their host from pathogenic attack. In the present study, we isolate and identify fungus Chrysosporium multifidum Hermetia illucens larvae. Extract C. culture broth supernatant showed moderate activity against strain methicillin-resistant Staphylococcus aureus (MRSA). Bioguided isolation extract resulted in characterization six α-pyrone derivatives (1–6) one diketopiperazine...
The adult Taenia solium, the pork tapeworm, usually lives as a single worm in small intestine of humans, its only known definitive host. Mechanisms genetic variation T. solium are poorly understood. Using three microsatellite markers previously reported [1], this study explored variability from cysts recovered experimentally infected pigs. It then epidemiology and transmission naturally pigs tapeworms human carriers an endemic rural community Peru. In initial on experimental infection, two...
Pyrazinamide (PZA) susceptibility testing in Mycobacterium tuberculosis (Mtb) is a current area of development and PZA-resistant strains are increasingly prevalent. Previous studies have demonstrated that the detection pyrazinoic acid (POA), metabolite produced by deamidation PZA, good predictor for PZA resistance since resistant strain would not convert into POA at critical required rate, whereas susceptible will do, expelling to extracellular environment certain allowing quantification...
Abstract The gut microbiota of insects contains a wide range organisms that protect them against the attack pathogens by releasing various types bioactive compounds. In present study, we report isolation and identification fungus Chrysosporium multifidum as component from larval Hermetia illucens. Extract broth culture C. showed moderate activity on strain methicillin-resistant Staphylococcus aureus (MRSA). bioguided extract resulted in characterization six α-pyrone derivatives ( 1 - 6 ) one...
Tuberculosis (TB), caused by Mycobacterium tuberculosis, is one of the 10 leading killer diseases in world. At least one-quarter population has been infected, and there are 1.3 million deaths annually. The emergence multidrug-resistant (MDR) extensively drug-resistant (XDR) strains challenges TB treatments. One drugs widely used first- second-line regimens pyrazinamide (PZA). Statistically, 50% MDR 90% XDR clinical resistant to PZA, recent studies have shown that its use patients with...
Los microorganismos acidófilos son predominantes en los ecosistemas de aguas ácidas minas, encontrándose abundancia la especie Acidithiobacillus ferrooxidans. El objetivo del estudio fue producir electricidad Celdas Combustible Microbianas (CCM) a partir tiosulfato el ánodo e ion férrico cátodo utilizando bacteria At. ferrooxidans LB151, cual caracterizada morfológicamente y molecularmente. Las técnicas electroquímicas utilizadas fueron cronoamperometría voltametría cíclica. La cíclica...