A5046941051- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- COVID-19 Clinical Research Studies
- Sarcoidosis and Beryllium Toxicity Research
- Medical Imaging and Pathology Studies
- Long-Term Effects of COVID-19
- Pulmonary Hypertension Research and Treatments
- Congenital Diaphragmatic Hernia Studies
- Genetic and Environmental Crop Studies
- Tuberous Sclerosis Complex Research
- Neonatal Respiratory Health Research
- Inhalation and Respiratory Drug Delivery
- Genetics and Plant Breeding
- COVID-19 and healthcare impacts
- Congenital Heart Disease Studies
- Histiocytic Disorders and Treatments
- COVID-19 diagnosis using AI
- Occupational exposure and asthma
- Legume Nitrogen Fixing Symbiosis
- Respiratory viral infections research
- Pleural and Pulmonary Diseases
- Transplantation: Methods and Outcomes
- Soybean genetics and cultivation
- Metaheuristic Optimization Algorithms Research
- Occupational and environmental lung diseases
Peter the Great St. Petersburg Polytechnic University
2008-2025
Moscow Clinical Scientific Center
2019-2024
Federal Medical-Biological Agency
2010-2024
City Clinical Hospital
2024
Kutafin Moscow State Law University
2024
Research Institute of Human Morphology
2019-2022
Pirogov Russian National Research Medical University
2022
Harran University
2020
LAC+USC Medical Center
2020
Commonwealth Scientific and Industrial Research Organisation
2020
The datasets on gene expression are the valuable source of information about functional state an organism. Recently, we have acquired large dataset segmentation genes in Drosophila blastoderm. To provide efficient access to data, developed FlyEx database (http://urchin.spbcas.ru/flyex). contains 4716 images 14 patterns obtained from 1579 embryos and 9 500 000 quantitative data records. Reference available for all cycles 11–13 temporal classes cycle 14A. supports operations patterns. can be...
The research aim is to study the morphological features of COVID-19 in lungs patients who died Moscow from March 20 June 6, 2020. Methods . Autopsy material 123 deceased (54 women, 69 men) with coronavirus infection (confirmed by PCR) was analyzed, median age 71 (30 – 94) years, and duration disease 14 (3 65) days. In all cases, patient's medical records autopsy reports were analyzed. Macro- microscopic changes evaluated observations. Results pathology corresponds various phases diffuse...
Abstract Background Mungbean ( Vigna radiata (L.) R. Wilczek, or green gram) is important tropical and sub-tropical legume a rich source of dietary protein micronutrients. In this study we employ GWAS to examine the genetic basis variation in several traits mungbean, using mini-core collection established by World Vegetable Center, which includes 296 accessions that represent major market classes. This has been grown common field plot southern European part Russia 2018. Results We used 5041...
Hypersensitivity pneumonitis (HP) is an inflammatory and/or fibrotic lung disease that occurs in response to repeated inhalation of broad-spectrum aerosol antigens. The prevalence HP ranges from 0.3 0.9 cases per 100,000 population. basis treatment therapy includes glucocorticoids, immunosuppressants, and antifibrotic drugs. target audience these clinical recommendations are general practitioners, pulmonologists, pathologists, radiologists, medical rehabilitation specialists. Methods. Each...
Chickpea is the second most important legume crop, which used as a food by people in different parts of world due to its high nutritive value. Omics technologies have revolutionized characterization chickpea genetic diversity considering single-nucleotide polymorphisms, while structural variants and transposons been overlooked. The specific contribution phenotypic diversification crop species still poorly documented, therefore important. We focused on landraces collected before “green...
The segmentation gene network in Drosophila embryo solves the fundamental problem of embryonic patterning: how to establish a periodic pattern expression, which determines both positions and identities body segments. gap constitutes first zygotic regulatory tier this process. Here we have applied systems-level approach investigate effect Kruppel (Kr) on expression. We acquired large dataset expression genes Kr null mutants demonstrated that levels these are significantly reduced second half...
This article contains clinical guidelines and current approaches to diagnosis treatment of idiopathic pulmonary fibrosis (IPF). The aims development this were improve early detection efficacy pharmacological non-pharmacological therapy IPF. Achieving these goals indicates improvement in medical care quality for patients. These are intended pulmonologists, therapeutists other specialists, healthcare managers providers
We analyzed lung material from 22 dead obtained on autopsy for the period March, 6 to April,30, 2020, in various clin-ics Moscow For this died 532 patients (219 female, 324 male),with mean age 67 47±14 years In all deceased patients, diagnosis of COVID-19 was confirmed vivo (PCR study nasopharynx, some by a positive PCR analysis trachea and tissue during autopsy) The average these 72 27±10 74 years, duration disease ranged 5 32 days severe COVID-19, develop viral interstitial pneumonia with...
Hypersensitivity pneumonitis (HP) is an interstitial lung disease (ILD) resulting from immune-mediated response in susceptible and sensitized individuals to a large variety of inhaled antigens. Chronic HP with fibrotic phenotype characterized by progression dismal prognosis. The aim this study was identify predictors mortality patients chronic real clinical practice.This retrospective, multicenter, observational used data registry 1355 fibrosing ILDs. included 292 diagnosed based on the...
Pulmonary function after COVID-19 in early convalescence phase. The aim of the study is to investigate influence Coronavirus disease 2019 (COVID-19) on pulmonary Materials and methods. included 44 patients (35 male) without concomitant bronchopulmonary pathology, with a median age 47.5 years. All underwent standard tests (PFTs): spirometry, body plethysmography, diffusion test. Besides, dyspnea mMRC scale was assessed, oxygen saturation level (SpO2 ) measured. Depending degree lung damage...
Background: Autopsies on COVID-19 deceased patients have many limitations due to necessary epidemiologic and preventative measures. The ongoing pandemic has caused a significant strain healthcare systems is being extensively studied around the world. Clinical data does not always corelate with post-mortem findings. goal of our study was find pathognomonic factors associated mortality in 100 full body autopsies. Materials Methods: Following safety protocol, we performed autopsies who were...
Idiopathic pulmonary fibrosis (IPF) is a specific form of chronic fibrotic interstitial pneumonia with progressive course and poor prognosis. The prevalence IPF in the Russian Federation about 8 – 12 cases per 100,000 population. basic treatment antifibrotic agents. Methodology . target audience these clinical recommendations are therapists, general practitioners, pulmonologists, pathologists, radiologists, medical rehabilitation doctors. Each thesis-recommendation diagnostic therapeutic...
Sarcoidosis is a multi-organ granulomatosis of unknown origin. Modern diagnostic methods allow detecting this disease at an early stage. The absence specific markers requires comprehensive approach to diagnosis based on comparison radiation, clinical, morphological and functional data. course sarcoidosis without damage the respiratory system presents significant difficulties. It extremely important understand time means starting Sarcoidosis’s treatment avoid initiation hormones cytostatics...
Background: Pathological anatomy, patogenesis and the morphogenesis of manifestations complications COVID-19 remain insufficiently studied. The fullest information on structural bases organs tissues alterations by new coronavirus disease can be obtained as a result autopsies.
 Aims: aim study was to morphological changes lungs other autopsies deceased persons. Results 2000 people who died severe form in Moscow, consisting 1212 men 788 women, from March 20 May 22, 2020 (a ratio 1.54:1)...
Summary. Differential Evolution Entirely Parallel (DEEP) package is a software for finding unknown real and integer parameters in dynamical models of biological processes by minimizing one or even several objective functions that measure the deviation model solution from data. Numerical solutions provided most efficient global optimization methods are often problem-specific cannot be easily adapted to other tasks. In contrast, DEEP allows user describe both mathematical function any...
World literature is paying increasing attention to the long-term course of COVID-19 and symptoms that appear after acute coronavirus infection. The symptoms, functional state lungs, X-ray changes are assessed. Nevertheless, post-COVID lung histology has not been described yet. aim this article study pathological in lungs COVID-19. Methods. We analyzed autopsy material from 19 deceased who had average age was 68.82 ± 14.6 years. All patients were found have IgG SARS-CoV-2. median time death...
Abstract Background Phenology data collected recently for about 300 accessions of Vigna radiata (mungbean) is an invaluable resource investigation impacts climatic factors on plant development. Results We developed a new mathematical model that describes the dynamic control time to flowering by daily values maximal and minimal temperature, precipitation, day length solar radiation. obtained parameters adaptation available experimental data. The models were validated cross-validation used...
Introduction. The pathogenesis of the novel coronavirus infection COVID-19 is being actively studied. Nevertheless, our up-to-date knowledge lymphoid tissue response in secondary immune organs dur-ing severe remains extremely limited. aim study was to evaluate patterns immu-nomorphological alterations lymph nodes patients with and assess lymphocytes functional activity them. Materials methods. Lymph node (autopsy material) from 17 deceased examined by histological immunohistochemical methods...
The myocardium of children with tetralogy Fallot (TF) undergoes hemodynamic overload and hypoxemia immediately after birth. Comparative analysis changes in the ploidy morphology right ventricular cardiomyocytes TF first years life demonstrated their significant increase compared control group. In TF, there was a predominantly diffuse distribution Connexin43-containing gap junctions over sarcolemma, which redistributed into intercalated discs as differentiation increased. number Ki67-positive...
Атлас явился итогом аутопсийной работы патологоанатомической службы Москвы по посмертной диагностике проявлений и осложнений COVID-19 в 2000 наблюдениях – самого большого мире объема вскрытий умерших от COVID-19. Это стало возможным благодаря тому, что Москве 100 % случаев летальных исходов с подозрением на производятся патологоанатомические вскрытия детальным клинико-морфологическим анализом. Результаты исследований легли основу новой методики, которая детализирует рекомендации ВОЗ выбору...
Since the beginning of pandemic, COVID-19 ( COronaVIrus Disease -2019) has been viewed as a respiratory disease with characteristic symptoms including cough, shortness breath, and difficulty breathing. However, some patients still have complaints post-inflammatory changes in lung tissue according to high-resolution computed tomography chest organs (CT scan) even after discharge from hospital. The aim. To assess functional system who had COVID-19-associated injury using comprehensive testing...
A 1D wavelet-based registration technique was applied to Drosophila segmentation gene expression data. We apply the fast redundant dyadic wavelet transform with a continuous basis as method for extracting ground control points. This chosen its basic properties, such noise reduction and good localization of characteristic features.