A5052910432- Synthesis and biological activity
- Advancements in Transdermal Drug Delivery
- Essential Oils and Antimicrobial Activity
- Metal complexes synthesis and properties
- Nanoparticle-Based Drug Delivery
- Cancer-related Molecular Pathways
- Protein Interaction Studies and Fluorescence Analysis
- Lipid Membrane Structure and Behavior
- Lanthanide and Transition Metal Complexes
- Bladder and Urothelial Cancer Treatments
- Synthesis and Characterization of Heterocyclic Compounds
- Cell death mechanisms and regulation
- Curcumin's Biomedical Applications
- RNA Interference and Gene Delivery
- Sirtuins and Resveratrol in Medicine
- Computational Drug Discovery Methods
- Thyroid Cancer Diagnosis and Treatment
- Cancer Cells and Metastasis
- Genomics, phytochemicals, and oxidative stress
- Epigenetics and DNA Methylation
- Bioactive Compounds and Antitumor Agents
- Antioxidant Activity and Oxidative Stress
- Synthesis and Biological Evaluation
- Click Chemistry and Applications
- Ferroptosis and cancer prognosis
Titu Maiorescu University
2023-2025
Romanian Academy
2016-2025
Institute of Virology of the Slovak Academy of Sciences
2016-2021
University of Bucharest
2016
Millennium Institute on Immunology and Immunotherapy
2012
University of Chile
2012
Medical University of Vienna
2012
Uppsala University
2012
Cold Spring Harbor Laboratory
2010
In order to develop novel chemotherapeutic agents with potent anticancer activities, a series of new 2,5-diaryl/heteroaryl-1,3,4-oxadiazoles were designed and synthesized. The structures the compounds established using elemental analyses, IR NMR spectral data. evaluated for their potential on two standardized human cell lines, HT-29 (colon adenocarcinoma) MDA-MB-231 (breast adenocarcinoma). Cytotoxicity was measured by MTS assay, while cycle arrest apoptosis assays conducted flow cytometer,...
The current study describes the synthesis, physicochemical characterization and cytotoxicity evaluation of a new series pyrrole derivatives in order to identify bioactive molecules. pyrroles were obtained by reaction benzimidazolium bromide with asymmetrical acetylenes 1,2-epoxybutane under reflux through Huisgen [3 + 2] cycloaddition several ylide intermediates corresponding dipolarophiles. salts from benzimidazole bromoacetonitrile. structures newly synthesized compounds confirmed...
Endometrial cancer is one the most prevalent gynecological cancers and, unfortunately, has a poor prognosis due to low response rates traditional treatments. However, progress in molecular biology and understanding genetic mechanisms involved tumor processes offers valuable information that led current classification describes four subtypes of endometrial cancer. This review focuses on pathogenesis cancers, such as mutations, defects DNA mismatch repair pathway, epigenetic changes, or...
Background/Objectives: Glioblastoma is the most common malignant primary brain tumor, characterized by necrosis, uncontrolled proliferation, infiltration, angiogenesis, apoptosis resistance, and genomic instability. Epigenetic modifiers hold promise as adjuvant therapies for gliomas, with synergistic combinations being explored to enhance efficacy reduce toxicity. This study aimed evaluate effects of single or combined treatments various anticancer drugs (Carboplatin, Paclitaxel, Avastin),...
Cancer is one of the leading causes mortality worldwide, and despite significant advances in treatment plans drug development, survival prospects are still low, side effects life altering. This article examines plant-derived extracts their therapeutic potential against various types hepatocellular carcinoma as a means inducing fewer compared to existing treatments. The focus on vitro synergistic effect silver bio-nanoparticles obtained from Clematis vitalba, Melissa officinalis, Taraxacum...
Four types of algae—Porphyra umbilicalis, Undaria pinnatifida, Cystoseira barbata, and Chlorella sp.—were used to obtain crude bioproducts enriched in polysaccharides (four bioproducts) create formulations with gold cations bioproducts). The obtained through aqueous extraction from barbata exhibited significant antioxidant activities a total polyphenol content (714.17 ± 1.26) mg GAE/L. In the derived extract Porphyra umbilicalis combined ions, nanoparticles sizes less than 34 nm were formed....
Background/Objectives: Cancer remains one of the leading causes mortality worldwide. Despite significant advancements in treatment strategies and drug development, survival rates remain low adverse effects conventional therapies severely impact patients’ quality life. This study evaluates therapeutic potential plant-derived extracts hepatocellular carcinoma treatment, with a focus on minimizing side while enhancing efficacy. Methods: research investigates vitro synergistic effect silver...
We report the synthesis and characterization of three new complexes natural flavonoid 5‐hydroxyflavone (primuletin) Al (III), Ga In respectively. The physico‐chemical properties structural features these novel compounds have been investigated by elemental thermogravimetric analysis, molar conductance several spectroscopic techniques, including FT‐IR, UV–Vis mass spectra. Based on experimental data, general chemical formula is [M (C 15 H 9 O 3 ) ] · n 2 O, where M cation = for 0 1, (III);...
Naringenin enhances the UV protection, photostability and cell viability of lipid based vegetable nanocarriers.
BACKGROUND: Thyroid carcinoma is the most common endocrine malignancy worldwide. Changes in DNA methylation can cause silencing of normally active genes, especially tumour suppressor genes (TSG) or activation silent genes. OBJECTIVE: The aim this study to evaluate degree pr omoter for a panel markers thyroid neoplasms and establish their relationship with oncogenesis. METHODS: To generate comprehensive signature TSGs involved neoplasia, we use Human TSG EpiTect Methyl II Signature PCR...
In head and neck cancers, the effectiveness of cisplatin (CisPt) treatment is limited by its toxicity, especially when higher doses are necessary, possible occurrence resistance. This study evaluated effects resveratrol (RSV) on expression different genes involved in response human tumor cells (FaDu, PE/CA-PJ49) to therapy. Our results revealed that RSV induced apoptosis amplification both FaDu PE/CA-PJ49 modulated specific differently than normal HaCaT cells. cells, combined CisPt + an...
Thiadiazole derivatives have garnered significant attention in the field of medicinal chemistry due to their diverse pharmacological activities, including anticancer properties. This article presents synthesis a series thiadiazole and investigates chemical characterization potential effects on various cell lines. The results nuclear magnetic resonance (NMR) analyses confirmed successful formation target compounds. was evaluated through silico vitro cell-based assays using LoVo MCF-7 cancer...
DNA methylation plays an important role in thyroid oncogenesis. The aim of this study was to investigate the connection between global and local status establish levels regulators (TET family DNMT1) tumours: follicular adenoma-FA, papillary carcinoma-PTC (classic carcinoma-cPTC carcinoma variant fvPTC).Global profile tumours tissue (41 paired samples) assessed by 5-methylcytosine 5-hydroxymethylcytosine evaluation (ELISA), along with TETs DNMT1 genes expression quantification. Also, it...
This study focuses on the design, characterization, and optimization of nanostructured lipid carriers (NLCs) loaded with docetaxel for treatment skin cancer. Employing a systematic formulation development process guided by Design Experiments (DoE) principles, key parameters such as particle size, polydispersity index (PDI), zeta potential, entrapment efficiency were optimized to ensure stability drug-loading efficacy NLCs. Combined XRD cryo-TEM analysis employed NLC nanostructure evaluation,...
The extracellular signal-regulated kinases (ERKs) are key transducers of the signals into intracellular responses and represent major molecular players in tumorigenesis. aim this study was to determine how curcumin (CRM) used as an adjuvant supports apoptotic process induced by a single chemical agent treatment (cisplatin-CisPT) on two head neck squamous cell carcinoma lines (FaDu PE/CA-PJ49) involvement ERK1/2 and/or p53 activation process. Data have shown that CisPt effect is potentiated...
“Drug repositioning” is a current trend which proved useful in the search for new applications existing, failed, no longer use or abandoned drugs, particularly when addressing issues such as bacterial cancer cells resistance to therapeutic approaches. In this context, six complexes of first-generation quinolone oxolinic acid with rare-earth metal cations (Y3+, La3+, Sm3+, Eu3+, Gd3+, Tb3+) have been synthesized and characterized. The experimental data suggest that acts bidentate ligand,...
Cisplatin is one of the most effective anticancer agents used to treat colon cancer, which third malignancy between common human cancers in world, but resistance developed represents an obstacle against full success chemotherapy. An emerging interest appeared finding other metallic compounds, such as ruthenium(III) complexes, for chemotherapeutic application cancer. Our study focused on activity several ruthenium (Ru) complexes with quinolone antibiotics tumor cell cultures. Real-time...
A novel nanoscale approach was developed for the improved cellular internalization of hybrid bovine serum albumin–lipid nanocarriers loaded with piperine (NLC-Pip–BSA) in different tumor cells. The effect BSA-targeted–NLC-Pip and untargeted-NLC-Pip on viability, proliferation, levels cell-cycle damage apoptosis colon (LoVo), ovarian (SKOV3) breast (MCF7) adenocarcinoma cell lines comparatively discussed. NLCs were characterized concerning particle size, morphology, zeta potential,...
New pyrrolo[1,2-b]pyridazines were synthesized by 3 + 2 cycloaddition reaction between mesoionic oxazolo-pyridazinones and methyl/ethyl propiolate. The compounds generated in situ action of acetic anhydride on 3(2H)pyridazinone acids obtained from corresponding esters alkaline hydrolysis followed acidification. structures the confirmed elemental analyses IR, 1H-NMR, 13C-NMR, X-ray diffraction data. regioselectivity was evidenced NMR spectroscopy analysis. evaluated for their cytotoxicity...
We report herein the synthesis and characterization of four new heteroleptic complexes Sm(III), Eu(III), Gd(III), Tb(III) with natural flavonoid 5‐hydroxyflavone (primuletin) 1,10‐phenanthroline. According to physicochemical characterization, mononuclear correspond general formula [Ln(OH) 2 L 1 ]· n H O , where = C 15 9 3 (deprotonated 5‐hydroxyflavone) 12 8 N (1,10‐phenanthroline), Ln is lanthanide cation, 4 for 3.5 Tb(III). A six‐coordinated distorted octahedron geometry was proposed...