A5079542910- Chronic Lymphocytic Leukemia Research
- Cell death mechanisms and regulation
- Cancer-related Molecular Pathways
- Calcium signaling and nucleotide metabolism
- Retinoids in leukemia and cellular processes
- Sirtuins and Resveratrol in Medicine
- Natural product bioactivities and synthesis
- RNA Interference and Gene Delivery
- Phytochemistry and Biological Activities
- Leptospirosis research and findings
- T-cell and Retrovirus Studies
- Toxin Mechanisms and Immunotoxins
- Advanced Breast Cancer Therapies
- Phytochemical compounds biological activities
- Curcumin's Biomedical Applications
- Diphtheria, Corynebacterium, and Tetanus
- Nitric Oxide and Endothelin Effects
- Viral Infections and Immunology Research
- Essential Oils and Antimicrobial Activity
- Cancer, Lipids, and Metabolism
- Cancer Research and Treatments
- Ginger and Zingiberaceae research
- Amoebic Infections and Treatments
- Magnetism in coordination complexes
- Diverse Scientific Research Studies
Romanian Academy
2016-2024
Inserm
1997-2002
Institut Curie
1997-2002
AbstractTrans-resveratrol, its dimer k -viniferin and two preparations of vineatrol (a grape-derived polyphenol fraction isolated from vine-shots extracts) were compared for their effects on the proliferation survival normal leukemic human lymphocytes. The different batches (vineatrol 10 25%) was obtained by HPLC fractionation contained 25% trans-resveratrol, respectively. polyphenols added to cultures cells chronic B cell malignancies (B-cell lymphocytic leukemia, B-CLL or hairy HCL)...
Endometrial cancer is one the most prevalent gynecological cancers and, unfortunately, has a poor prognosis due to low response rates traditional treatments. However, progress in molecular biology and understanding genetic mechanisms involved tumor processes offers valuable information that led current classification describes four subtypes of endometrial cancer. This review focuses on pathogenesis cancers, such as mutations, defects DNA mismatch repair pathway, epigenetic changes, or...
Summary. Trans ‐resveratrol was analysed for its apoptotic and growth inhibitory activity in human B‐cell lines derived from chronic malignancies (WSU‐CLL ESKOL), leukaemic lymphocytes patients with lymphocytic leukaemia (B‐CLL). Resveratrol displayed antiproliferative on both lines, as estimated by the decrease cell recovery inhibition of thymidine uptake. Furthermore, resveratrol induced apoptosis two well B‐CLL patients' cells, evidenced increase annexin V binding, caspase activation, DNA...
In head and neck cancers, the effectiveness of cisplatin (CisPt) treatment is limited by its toxicity, especially when higher doses are necessary, possible occurrence resistance. This study evaluated effects resveratrol (RSV) on expression different genes involved in response human tumor cells (FaDu, PE/CA-PJ49) to therapy. Our results revealed that RSV induced apoptosis amplification both FaDu PE/CA-PJ49 modulated specific differently than normal HaCaT cells. cells, combined CisPt + an...
In this study, three types of extracts isolated from leaves Plantain (Plantago lanceolata) were tested for their chemical content and biological activities. The bioproducts are combinations polysaccharides polyphenols (flavonoids iridoidic compounds), they antioxidant, antifungal, antitumor, prebiotic activity (particularly fraction). Briefly, the iridoid-enriched fraction has revealed a pro-oxidant activity, while flavonoid-enriched had high antioxidant potency; polysaccharide also...
Natural compounds can modulate all three major phases of carcinogenesis. The role the natural such as resveratrol (RSV) and curcumin (CRM) in modulation anticancer potential platinum-based drugs (CisPt) is still a topic considerable debate. In order to enhance head neck cancer (HNSCC) cells’ sensitivity cytotoxic effects CisPt combined treatments with RSV or CRM were used. study aim was evaluate how associated treatment modulated some cellular processes proliferation, P21 gene expression,...
The extracellular signal-regulated kinases (ERKs) are key transducers of the signals into intracellular responses and represent major molecular players in tumorigenesis. aim this study was to determine how curcumin (CRM) used as an adjuvant supports apoptotic process induced by a single chemical agent treatment (cisplatin-CisPT) on two head neck squamous cell carcinoma lines (FaDu PE/CA-PJ49) involvement ERK1/2 and/or p53 activation process. Data have shown that CisPt effect is potentiated...
The paper presents the results of studies performed to establish effect mixtures between limonene and clotrimazole against microbial pathogens involved in dermatological diseases, such as Candida albicans, Staphyloccocus aureus, Escherichia coli. Preliminary data obtained from microplates revealed a possible synergism mixture for Staphylococcus aureus. Studies “in silico” with programs CLC Drug Discovery Workbench MOLEGRO Virtual Docker, gave favorable scores docking each compound on...
The soluble cleavage fragment of the low‐affinity immunoglobulin E (IgE) receptor/CD23 (sCD23 25 000 MW) and antibodies directed against their receptors on monocytes, CD11b CD11c, stimulate production nitric oxide (NO) by these cells we have suggested that enzyme involved could be related to endothelial constitutive type III synthase (ecNOS). In present work, analysed characteristic properties this NOS isoform in model human promonocytic U937 By reverse‐transcription polymerase chain...
The beneficial effects of metabolites resulted from the consortium probiotic microorganisms are known since year 220 B.C. when they were used in Asia. these consortia brought into actuality last century, after second World War, by researchers Moscow Academy Sciences, during studies regarding incidence cancer Russia. They have found that at residents some areas heavily polluted with radiation, it is practically non-existent. Further investigations revealed people healthy, due to consumption a...
Two biomaterials obtained by hydrodistilation from an indigenous Satureja hortensis plant (SHEO), and the rhizoms of Zingiber officinale (ZOEO), purchased Romanian market, were tested in order to evaluate their effect on monocytic cells line type THP-1. The first biomaterial, has practically no biological whereas other bioproduct, (ZOEO) a better comparison L-NAME etoposide. Due mechanism which implies apoptosis quantities nitric oxide (NO)produced THP-1 are reduced under ZOEO action.
Uncontrolled cellular proliferation characterizes the tumor growth and metastasis, usually being result of multiple genetic epigenetic insults to cell, particularly involving protooncogenes suppressor genes.The angiogenesis process, inducted by a tumor, is controlled influenced angiogenic angiostatic factors, that involves complex interaction between endothelial cells.Tumor cell invasion metastasis are promoted upregulation such as vascular factor (VEGF), or adhesion molecules, like...
El presente informe de investigación aborda el manejo los despidos laborales durante la pandemia COVID-19 en sector privado del Cantón Machala. contexto que se desarrolla estudio es crisis sanitaria generada por y su impacto esfuerzos reactivación económica país. objetivo principal analizar las causas consecuencias provocados empresas Para lograrlo, plantean objetivos específicos como identificar laborales, políticas públicas implementadas para determinar afectaciones directas e indirectas...
Although cisplatin (CisPt) is used in treating head and neck squamous cell carcinomas (HNSCC), little known about the cellular mechanisms triggered.We examined morphological functional changes HNSCC cells when natural compounds such as resveratrol (RSV) are added to CisPt treatment of FaDu human pharyngeal carcinoma line.In addition, we analyzed effects and/or RSV treatments on proliferation evaluated ability modulate activation p38 Mitogen-Activated Protein Kinase (p38MAPK).Moreover,...
The essential oil obtained from Melaleuca alternifolia (TTO) is recognized due to its antimicrobial properties. TTO was purchased the Romanian market, be used in experiments regarding their effect against monocytic leukemia cells. Bioproduct analysis indicates a content of 34.8% terpineol, 13.5% p-cymene, 10.72% γ-Terpinene, 7.9% Levo-carvone, 6.7% terpinene-4-ol, and 5.7% α-Pinene, as main compounds. Chemiluminescence studies indicate prooxidant properties for TTO. If THP-1 cells line...
Topic: 30. Infections in hematology (incl. supportive care/therapy) Background: The profound immune dysregulation of patients (pts) with chronic lymphocytic leukemia (CLL) put them at risk severe COVID19. Previous studies showed that seroconversion rate after SARS-Cov-2 vaccine pts CLL was lower than the healthy population, particular those on active treatment. Little is known about cellular-mediated responses and effect targeted therapies upon infection vaccination. Aims: We aimed...