A5071485774- MicroRNA in disease regulation
- Metabolism and Genetic Disorders
- Cancer-related molecular mechanisms research
- Extracellular vesicles in disease
- Trypanosoma species research and implications
- Glaucoma and retinal disorders
- T-cell and B-cell Immunology
- Organ and Tissue Transplantation Research
- Cancer, Hypoxia, and Metabolism
- Ion channel regulation and function
- Advanced Glycation End Products research
- Reconstructive Surgery and Microvascular Techniques
- Prostate Cancer Treatment and Research
- PI3K/AKT/mTOR signaling in cancer
- Cytokine Signaling Pathways and Interactions
- Epigenetics and DNA Methylation
- Gout, Hyperuricemia, Uric Acid
- RNA modifications and cancer
- Quality and Safety in Healthcare
- Lysosomal Storage Disorders Research
- Renal and related cancers
- Spondyloarthritis Studies and Treatments
- Bone and Joint Diseases
- Transplantation: Methods and Outcomes
- Parathyroid Disorders and Treatments
Central South University
2012-2022
Second Xiangya Hospital of Central South University
2012-2022
Capital Medical University
2008
Arterial calcification is a common cardiovascular disease that initiates from process of osteoblastic differentiation vascular smooth muscle cells (VSMCs). Accumulating evidence has demonstrated microRNAs play an important role in regulating arterial calcification. miR-204 was significantly downregulated calcified human renal arteries patients with uremia; mice, due to 5/6 nephrectomy high-phosphate diet (5/6 NTP); and VSMCs induced by high phosphate concentration. The overexpression...
Recent studies have demonstrated the critical roles of micro-RNAs in tumorigenesis and tumor progression. Here, we describe regulation function miR-490-5p bladder cancer.Paired tissue samples were collected from cancer patients (n = 20). Real-time PCR revealed that expression was significantly down-regulated human tissues cells. Also there an inverse relationship between level pathological grade cancer. Western blotting performed to detect levels c-FOS TET1 6 matched 4 cell lines....
Vascular calcification is one of the most important factors for cardiovascular and all-cause mortality in patients with end-stage renal diseases (ESRD). The current study was aimed to investigate function mechanisms miR-34b on vascular smooth muscle cells (VSMCs) both vitro vivo. We found that expression significantly suppressed VSMCs high inorganic phosphate (Pi) treatment, as well mouse arteries derived from 5/6 nephrectomy a high-phosphate diet (0.9% Pi, NTP) human uraemia patients....
Aberrant expression of CAV3.1, one T-type Ca2+ channels, is reported to exert important functions in pathological processes, including carcinogenesis. However, its pattern and function prostate cancer (PCa) remains unclear.The CAV3.1 was analyzed multiple ways, online analysis Oncomine database, experimental analyses cell lines, collected clinical specimens using immunohistochemistry, quantitative reverse transcription polymerase chain reaction, Western blot. Then, downregulated PCa cells...
NDUFA4L2 is overexpressed in VHL-deficient cell lines and neuroblastoma. The clinical significance of clear renal carcinoma (ccRCC) has not been well studied. Therefore, we evaluated the prognostic value ccRCC patients.In our study, expression 86 cases adjacent normal tissues was monitored by immunohistochemistry, semi-quantitative RT-PCR, Western blot analyses. relationship between features assessed.The results showed that protein found to be higher 81.4% (70/86) than 26.7% (23/86) (p =...
To determine the expression and mechanism of osteoactivin (OA) in kidney by establishing SD rat model acute cyclosporine A (CsA) toxicity.SD rats were fed with normal diet for a week, which they then randomly divided into 3 groups: an experimental group (gavage cycloporin olive oil), vector control saline). killed 2 days, 1 or weeks after gavage to examine serum creatinine (SCr) body weight. HE staining was used detect histopathological change. Immunohistochemistry observe degree area OA....
Introduction:The mouse heterotopic cardiac transplant model has been extensively used to explore immunity.Although the cuff technique facilitates operation, procedure remains difficult, and vessel eversion is most difficult step.Cuff movement everted wall slippage are main adverse factors in eversion.Traditional strategies prevent these focus on fixation, while more steps or surgical instruments would be required.Methods: According reported protocols our experience, skills were modified for...
The safe-care practiced by the Second Xiangya Hospital of Central South University is designed to make continued improvements quality care and enhance hospital management.The paper first explained concept model as upholding spirit,standardized management,good clinical service pattern,enhanced continuing education training,enhanced doctor-patient communication,risk prevention beforehand,enhanced team spirit,and enhanced information system.It went on describe measures taken in implementing...