A5064243682- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Respiratory and Cough-Related Research
- Epilepsy research and treatment
- Inhalation and Respiratory Drug Delivery
- Systemic Lupus Erythematosus Research
- Pharmacological Effects and Toxicity Studies
- Food Allergy and Anaphylaxis Research
- Urticaria and Related Conditions
- Hepatitis C virus research
- Natural Language Processing Techniques
- Dermatology and Skin Diseases
- Pediatric health and respiratory diseases
- Ocular Surface and Contact Lens
- Metabolism and Genetic Disorders
- Glioma Diagnosis and Treatment
- Sinusitis and nasal conditions
- Galectins and Cancer Biology
- IL-33, ST2, and ILC Pathways
- Rheumatoid Arthritis Research and Therapies
- Mast cells and histamine
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Diet and metabolism studies
- Cell Adhesion Molecules Research
- Systemic Sclerosis and Related Diseases
New York Hospital Queens
2025
NewYork–Presbyterian Hospital
2025
Cornell University
2025
Ospedale Policlinico San Martino
2015-2024
University of Genoa
2015-2024
University of Foggia
2023-2024
Sapienza University of Rome
2020
Humanitas University
2017
University of Naples - L'Orientale
2017
Istituti di Ricovero e Cura a Carattere Scientifico
2013-2014
We conducted a double-blind trial of high-dose parenteral 6-methylprednisolone (MP) and placebo on 23 patients with acute MS. After the trial, were given corticosteroids in gradually decreasing doses. The frequency improvement was significantly higher bout duration lower MP group than group. first signs (3 to 6 days after starting MP) associated marked decrease rate CNS IgG synthesis, but CSF oligoclonal bands did not change. production slowly returned toward baseline despite progressive...
Severe persistent asthma causes a substantial morbidity and mortality burden is frequently not well controlled, despite intensive guideline-based therapy. The unique monoclonal antibody approved for patients with severe allergic omalizumab: recombinant humanised murine against IgE antibodies. aim of the present study to investigate effect long-term anti-IgE on thickening reticular basement membrane (RBM) eosinophil infiltration in bronchial biopsies from asthma. Biopsies were obtained 11...
Asthma is a chronic inflammatory disease.Reticular basement membrane (RBM) thickening considered feature of airway remodelling (AR) particularly in severe asthma (SA).Omalizumab, mAb to IgE effective SA and can modulate AR.Herein we describe protein profiles bronchial biopsies detect biomarkers anti-IgE effects on AR explain potential mechanisms/pathways.We defined the biopsy profiles, before after treatment.Unsupervised clustering baseline proteomes resulted very good agreement with...
Bronchial asthma is a heterogeneous disease characterized by three cardinal features: chronic inflammation, variable airflow obstruction, and airway hyperresponsiveness. Asthma has traditionally been defined using nonspecific clinical physiologic variables that encompass multiple phenotypes are treated with anti-inflammatory therapies. Based on the modulation of remodeling after 12 months anti-immunoglobulin E (IgE) treatment, we identified two (omalizumab responder, OR; non-omalizumab NOR)...
Reticular basement membrane (RBM) thickness and airway responses to inhaled methacholine (MCh) were studied in perennial allergic asthma ( n = 11), rhinitis 8), seasonal 5), chronic obstructive pulmonary disease (COPD, 9). RBM was significantly thicker (10.1 ± 3.7 μm) (11.2 4.2 than (4.7 0.7 COPD (5.2 μm). The dose (geometric mean) of MCh causing a 20% decrease 1-s forced expiratory volume (FEV 1 ) higher (1,073 μg) (106 μg). In COPD, the slope linear regression all values vital capacity...
Thymic stromal lymphopoietin (TSLP), is a protein belonging to class of epithelial cytokines commonly called alarmins, which also includes IL-25 and IL-33. Functionally, TSLP key player in the immune response environmental insults, initiating number downstream inflammatory pathways. performs its role by binding high-affinity heteromeric complex composed thymic receptor (TSLPR) chain IL-7Rα. In recent years, important proinflammatory etiopathogenesis various chronic diseases such as asthma,...
Malignant hyperthermia (MH) is a rare genetic disorder triggered by inhalational anesthetics or depolarizing neuromuscular blocking agents that carries significant mortality if not promptly treated. The following case presents healthy 39-year-old man who developed MH several hours into an anesthetic exposure. Rapid intraoperative stabilization tactics paralleled intensive care unit (ICU) level allowed for continuation of operative management as opposed to termination given the patient was at...
Studies over 10 yr have demonstrated local nasal immunotherapy (LNIT) to be an effective treatment for rhinitis due pollens and mites. The aim of our work was investigate the effects LNIT on inflammatory phenomena, employing model allergenic challenge, since no evidence has been yet provided about events allergic reactions. We evaluated, in addition, possible some systemic immunologic parameters its clinical efficacy. study involved a double-blind, placebo-controlled trial preseasonal with...
Three of 37 adolescents in long-term remission from childhood acute lymphoblastic leukemia (ALL) developed malignant multifocal gliomas several years after completing treatment that included central nervous system (CNS) prophylaxis with radiation (RT) and intrathecal methotrexate (IT-MTX). No recurrence the was evident when CNS tumors were discovered. Seventeen other similar cases have been recorded. The occurrence second malignancies is reviewed context this development oncogenic effects...
Background: Omalizumab may modulate airway remodeling in severe asthma. Using forced expiratory volume 1 second (FEV ) as a surrogate of remodeling, we aimed to investigate if an omalizumab add-on allergic asthma lead persistent reversal obstruction and evaluate the potential biomarkers reversibility. Methods: Data were collected before (T0) after for year (T1, 32 patients), 2 years (T2, 26 patients) 4 (T4, 13 patients). All patients had baseline FEV below 80 % predicted (60.5 ± 12.5 %)....
There is, so far, no universal definition of severe asthma. This usually relies on: number exacerbations, inhaled therapy, need for oral corticosteroids, and respiratory function. The use such parameters varies in the different definitions used. Thus, according to chosen, each patient may result having asthma or not. aim this study was evaluate how choice a specific can change allocation patients.Data collected from Severe Asthma Network Italy (SANI) registry were analyzed. All patients...
The efficacy mepolizumab in severe asthmatic patients is proven the literature. Primarily to study effect of on exacerbations, steroid dependence, and continuation long term. Secondarily evaluate drug nasal polyps. Analyzing data from SANI (Severe Asthma Network Italy) clinics, we observed treated with 100 mg/4 weeks, for a period 3 years. 157 were observed. Exacerbations reduced first year (−84.6%) progressively 90 95% second third ones. Steroid-dependent decreased 54% 21% subsequently 11%...