A5052722112- Liver physiology and pathology
- Urticaria and Related Conditions
- Cell death mechanisms and regulation
- Cancer-related Molecular Pathways
- Dermatology and Skin Diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Mast cells and histamine
- Mesenchymal stem cell research
- Retinoids in leukemia and cellular processes
- Flavonoids in Medical Research
- Chemokine receptors and signaling
- Lung Cancer Treatments and Mutations
- Cancer, Hypoxia, and Metabolism
- Process Optimization and Integration
- S100 Proteins and Annexins
- Environmental Impact and Sustainability
- Fluoride Effects and Removal
- Monoclonal and Polyclonal Antibodies Research
- interferon and immune responses
- Organ Transplantation Techniques and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Carbon Dioxide Capture Technologies
- Allergic Rhinitis and Sensitization
- HER2/EGFR in Cancer Research
- Cancer Mechanisms and Therapy
Ajou University
2013-2024
University of Suwon
2016
Hanyang University
2015
Abstract Human papillomavirus (HPV) is a major causative factor of head and neck squamous cell carcinoma (HNSCC), the incidence HPV ‐ associated HNSCC increasing. The role tumor microenvironment in viral infection metastasis needs to be explored further. We studied molecular characteristics primary tumors (PTs) lymph node metastatic (LNMTs) by stratifying them based on their status. Eight samples for single‐cell RNA profiling six spatial transcriptomics (ST), composed matched (PT) metastases...
Bone marrow-derived mesenchymal stromal cells (MSCs) have been reported to be beneficial for the treatment of liver fibrosis. Here, we investigated use genetically engineered MSCs that overexpress hepatocyte growth factor (HGF) as a means improve their therapeutic effect in Liver fibrosis was induced by intraperitoneal injection dimethylnitrosamine. HGF-secreting (MSCs/HGF) were prepared transducing with an adenovirus carrying HGF-encoding cDNA. or MSCs/HGF injected directly into spleen...
Platelet activating factor (PAF) is an endogenous, active phospholipid released from inflammatory cells, platelets, and endothelial involved in the regulation of immune responses. Degradation PAF by acetylhydrolase (PAF-AH) has been shown to be associated with anaphylaxis, asthma, peanut allergy. The purpose this study was investigate relationships among clinical parameters, including urticaria severity treatment responsiveness, PAF-AH levels sera patients chronic spontaneous (CSU). Serum...
Mas-related G-protein coupled receptor-X2 (MRGPRX2), a receptor on mast cells, basophils, and eosinophils associated with immunoglobulin E (IgE)-independent degranulation, has been reported to be highly expressed cutaneous cells in patients severe chronic spontaneous urticaria (CSU). We sought investigate whether MRGPRX2 levels the sera from CSU differ those healthy control subjects evaluate clinical utility of patients. Severe was defined as activity score over 7 days (UAS7) ≥ 28. Serum...
Aberrant activation of hepatocyte growth factor/scatter factor (HGF/SF) and its receptor, Met, is involved in the development progression many human cancers. In cell-based screening assay, (-)epigallocatechin-3-gallate (EGCG) inhibited HGF/SF-Met signaling as indicated by inhibitory activity on HGF/SF-induced cell scattering uPA (IC50=15.8 microgram/ml). Further analysis revealed that EGCG at low doses specifically tyrosine phosphorylation Met but not epidermal (EGF)-induced EGF receptor...
Pervanadate, a complex of vanadate and H2O2, has an insulin mimetic effect, acts as inhibitor protein tyrosine phosphatase. Pervanadate-induced phospholipase D (PLD) activation is known to be dependent on the phosphorylation cellular proteins kinase C (PKC) activation, yet underlying molecular mechanisms are not clearly understood. Here, we investigated signaling pathway pervanadate-induced PLD in Rat2 fibroblasts. Pervanadate increased activity dose- time- manner. Protein inhibitor,...
Abstract Background Anti‐heat shock protein (HSP) autoantibodies are detected in autoimmune diseases. We sought to ascertain whether anti‐HSP10 IgG is present patients with CSU and elucidate the role of HSP10 pathogenesis. Method Using a human proteome microarray, six potential had higher expression 10 samples compared normal controls (NCs). Among them, autoantibody was quantified by immune dot‐blot assay sera from 86 44 NCs. The serum levels microRNA‐101‐5p were measured effects miR‐101‐5p...
Anaplastic thyroid carcinoma (ATC) is an aggressive human tumor with a median survival of 6 months. We previously developed agonistic anti-death receptor 4 MAB, AY4, and demonstrated the antitumor effects AY4 in head neck cancer cells. Presently, we show that ATC cells are sensitive to sensitivity correlates reduced expression level Bcl-xL reactive oxygen species (ROS) generation. induced death C-643, U-HTH 7, HTH83, SW1736 To elucidate role ROS generation AY4-induced apoptosis cells, 7 were...
Chronic spontaneous urticaria (CSU) is a common cutaneous disease caused by mast-cell degranulation. Human β-defensin 2 (HBD2) well-known antimicrobial peptide that also pruritogen inducing vascular permeability via non-IgE-mediated degranulation.We investigated the associations between serum HBD2 levels and clinical characteristics of CSU patients.Serum samples from 124 patients 56 healthy controls were screened for translationally controlled tumor protein (TCTP)_ using ELISA. The activity...
Abstract Nasopharyngeal carcinoma (NPC) is a common malignant tumor with high invasive and metastatic potential. The hepatocyte growth factor (HGF)-Met signaling pathway has critical role in mediating the of many different types cancer, including head neck squamous cell carcinoma. HGF also stimulates NPC invasion line model. In this study, we determined inhibitory effect Met, using Met-targeting monoclonal antibody (SAIT301), on potential lines. Met inhibition by SAIT301 resulted highly...
Abstract Background: Anaplastic thyroid carcinoma (ATC) is an aggressive human tumor with a median survival of 6 months. We previously developed agonistic anti-death receptor 4 monoclonal antibody, AY4, and demonstrated the anti-tumor effects AY4 in head neck cancer cells. Presently, we show that ATC cells are sensitive to sensitivity correlates reduced expression level Bcl-xL reactive oxygen species (ROS) generation. Methods: The Thyroid cell lines (C-643, U-HTH7, HTH83 SW1736) was studied...
Abstract Background and purpose: It has been reported that the abnormal activation of receptor tyrosine kinases is associated with development many human carcinomas high EGFR Met mediates tumorigenicity laryngeal carcinoma. In this study, we have done therapeutic efficacy ME22S, a novel EGFR/Met bispecific antibody, in carcinoma vitro vivo was thoroughly evaluated. Methods: The effects ME22S on cell viability assessed through MTT assays, then Western blotting immunocytochemistry were used to...
Abstract Various chemotherapeutic agents have been demonstrated to induce senescence of cancer cells in vitro and vivo. This therapy-induced (TIS) has regard as a favorable therapeutic response, although it is not cell death but permanent cycle arrest. However, adverse aspects TIS also suggested since senescence-associated secretory phenotype (SASP) enables affect microenvironment senescent cells. Nonetheless, when are intermingled with non-senescent after chemotherapy, the effects SASP from...
This work was supported by a grant from the National Research Foundation of Korea (NRF) funded government (MSIP) (NRF-2018R1A2B6006199) and research Ahn-Gook Pharmaceutical Co, Ltd, Seoul, Republic Korea. Platelet activating factor (PAF) is one most potent phospholipid released platelets as well various inflammatory cells. PAF has been known to play role in regulation immune responses allergic inflammation. study aimed compare circulating levels PAF-acetylhydrolase (AH) which can catabolize...