A5010508781- Antimicrobial Resistance in Staphylococcus
- Antibiotic Resistance in Bacteria
- COVID-19 and Mental Health
- Bacterial biofilms and quorum sensing
- Mycobacterium research and diagnosis
- Salmonella and Campylobacter epidemiology
- Central Venous Catheters and Hemodialysis
- Streptococcal Infections and Treatments
- Bacterial Identification and Susceptibility Testing
- Antifungal resistance and susceptibility
- Infective Endocarditis Diagnosis and Management
- COVID-19 epidemiological studies
- Clostridium difficile and Clostridium perfringens research
- Chronic Kidney Disease and Diabetes
- SARS-CoV-2 and COVID-19 Research
- Amoebic Infections and Treatments
- COVID-19 and healthcare impacts
- Infection Control and Ventilation
- Viral gastroenteritis research and epidemiology
- Antibiotics Pharmacokinetics and Efficacy
- Infections and bacterial resistance
- Antibiotic Use and Resistance
- Tuberculosis Research and Epidemiology
- Enterobacteriaceae and Cronobacter Research
- Legionella and Acanthamoeba research
Tokyo Medical University Hospital
2015-2024
Kyoto Prefectural University of Medicine
2021-2024
Tokyo Medical University
2014-2024
Oita University
2013
Tokyo Metropolitan Bokutoh Hospital
2008-2009
Tokyo Metropolitan Komagome Hospital
2009
Hakodate Central General Hospital
2003
Sunagawa City Medical Center
1991
National Hospital Organization
1987
Nagasaki University
1967
Vaccination could be a key protective measure against coronavirus disease 2019 (COVID-19), and it is important to understand the acceptability of COVID-19 vaccine among general public. However, there no study on acceptance in Japan. Therefore, this aimed describe hesitancy situation Japan assess factors associated with such issues. This was cross-sectional based an internet survey completed by 2956 people. Participants were asked indicate how likely they get vaccinated for COVID-19. In...
The purpose of this study was to identify the clinical characteristics and outcomes peripheral vascular catheter-related bloodstream infections (PVC-BSIs) determine risk severe complications or death. We performed a retrospective observational from June 2010 April 2015 at two regional university-affiliated hospitals in Tokyo. studied manifestations, underlying diseases, laboratory results, treatment methods, recurrence rates, 62 hospitalized patients diagnosed with PVC-BSIs by positive blood...
Background: This longitudinal study aimed to examine the changes in psychological distress of general public from early community-transmission phases COVID-19 pandemic and investigate factors related these changes.
Since the emergence of COVID-19 pandemic, use face masks by healthy individuals for prevention has been attracting public attention. However, efficacy depends on proper usage. We set out to determine prevalence wearing prevent and compliance with appropriate measures correct among general in Japan where medical is a “cultural” normality. This cross-sectional study was based an internet-based survey completed 2141 people (50.8% men, aged 20–79 years) who were selected registrants Internet...
Although community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has emerged worldwide, no nationwide CA-MRSA surveillance been conducted in Japan to determine the changes its molecular characteristics over time. We aimed characterize epidemiology of Panton-Valentine leucocidin (PVL)-positive strains collected from across past decade. isolated 1,770 MRSA skin and pus samples outpatients 244 medical facilities 31 prefectures between 2010 2018 (2010, 2012, 2014, 2016, 2018)....
The Mycoses Forum in Japan has developed management bundles for candidaemia to incorporate into bedside practice. aim of this study was investigate nationwide compliance with the and their impact on clinical outcomes. Non-neutropenic patients treated antifungals were surveyed. Bundles consist nine items complete. Data sent central office between July 2011 April 2012. Six hundred eight analysed. rate achieving all elements 6.9%, it increased 21.4% when analysed by bundle except oral switch....
Vaccine hesitancy regarding the coronavirus disease 2019 (COVID-19) vaccine is widespread during COVID-19 pandemic. Many recent studies have reported that confidence of vaccination and perceived risk were associated with intent, yet few focused on other psychological factors. This study aimed to clarify trends in intent identify association between 5C antecedents by sex age Japan. was a longitudinal conducted through an Internet-based survey from January 2021 April before after distribution...
Abstract Kidney hypertrophy is a common clinical feature in patients with diabetes and associated poor renal outcomes. Initial cell proliferation followed by cellular are considered the responsible mechanisms for diabetic kidney hypertrophy. However, whether similar responses against hyperglycemia continue chronic phase unclear. We performed lineage tracing analysis of proximal tubular epithelia using novel type 2 mice tamoxifen-inducible tubule-specific fluorescent reporter. Clonal...
IntroductionA reduced salt intake is a vital lifestyle modification in the management of hypertension. Initiatives aimed at decreasing are based on preference by humans for taste. Salt behavior appears to be affected balance between attraction low taste and aversion high However, has not yet been quantitively investigated both healthy individuals CKD patients.MethodsAssessments gustatory thresholds salt, bitter, sour, sweet tastes were performed using stimulant-impregnated test strip...
ObjectivesTo clarify changes in the implementation of personal protective measures among ordinary Japanese citizens from early phase COVID-19 outbreak to community transmission phase.MethodsThis longitudinal, internet-based survey included 2141 people (50.8% men; 20–79 years). The baseline and follow-up surveys were conducted February 25–27, 2020, April 1–6, respectively. Participants asked how often they implemented five recommended by World Health Organization (hand hygiene, social...
Cisplatin is a commonly used anticancer drug, but nephrotoxicity dose-limiting adverse effect. Recent experimental and clinical observations have demonstrated that multiple injections of cisplatin induce the transition to chronic kidney disease; however, underlying mechanisms remain unclear. We found higher doses in shorter interval affected severity injury, causing fibrosis develop at later time point. An additional injection during recovery period after prior when proximal tubule epithelia...
To reduce vaccine hesitancy, it is important to identify factors that can intervene at the individual or community level. Social capital a possible factor because associated with various such as for measles and influenza. However, limited studies have explored association between social vaccination COVID-19, which an unprecedented pandemic infodemic. Therefore, this study aimed clarify COVID-19 during pandemic. This cross-sectional used quota sampling online-based survey. Participants were...
Background It has been indicated that the health impact of COVID-19 is potentially greater in individuals from lower socioeconomic status than overall population. Aims To examine how spread altered general public's mental health, and whether such changes differ relation to individual income. Method An online longitudinal survey was conducted at three different time periods during pandemic. We recruited 1993 people aged 20–70 years, living Tokyo metropolitan area Japan. Participants’ measured...
The coronavirus disease 2019 (COVID-19) has a tremendous influence in general public's behaviors; however, changes the status of regularly scheduled outpatient visits Japan during COVID-19 pandemic are still unknown.This cross-sectional study was conducted May 2020. Participants were recruited by an Internet-based survey company. A total 659 patients (54% male, average age 60 ± 14 years) who had prior to onset enrolled. answered four questions ("decrease medical visit frequency," "inability...
Abstract Streptozotocin (STZ), an anti-cancer drug that is primarily used to treat neuroendocrine tumors (NETs) in clinical settings, incorporated into pancreatic β-cells or proximal tubular epithelial cells through the glucose transporter, GLUT2. However, its cytotoxic effects on kidney have been underestimated and underlying mechanisms remain unclear. We herein demonstrated DNA damage subsequent p53 signaling were responsible for development of STZ-induced injury. detected NET patients...
Cupriavidus gilardii is an aerobic, Gram-negative, glucose-nonfermenting rod that was first identified in 1999. Because of the difficulty accurate species identification C. gilardii, there are few case reports infection caused by this organism. In previous reports, has been characterized as organism with low pathogenicity causes opportunistic infections. We encountered a pacemaker-associated bloodstream 90-year old woman without obvious immunodeficiency. isolates sequencing 16S rRNA gene....
Abstract Background Self-isolation is an important personal protective measure in inhibiting the transmission of coronavirus disease 2019 (COVID-19) as people carry out economic and social activities amid its spread. Yet few studies have clarified actual implementation status self-isolation during outbreak. This study aimed to reveal among Japanese workers COVID-19 outbreak factors this measure. Methods was a cross-sectional based on internet survey completed by 1,226 (60.0% men) living 7...
Seasonal trends in tuberculosis (TB) notifications have been observed several countries but are poorly understood. Explanatory factors may include weather, indoor crowding, seasonal respiratory infections and migration. Using enhanced citywide TB surveillance data collected over nine years Blantyre, Malawi, we set out to investigate how weather seasonality affect temporal case notification rates (CNRs) across different demographic groups. We used from prospective between April 2011 December...