A5067969416- Pharmacological Effects of Natural Compounds
- Bone Metabolism and Diseases
- Seed and Plant Biochemistry
- Menopause: Health Impacts and Treatments
- Redox biology and oxidative stress
- Healthcare and Venom Research
- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Atherosclerosis and Cardiovascular Diseases
- Sulfur Compounds in Biology
- Mitochondrial Function and Pathology
- S100 Proteins and Annexins
- Neuroscience and Neuropharmacology Research
- Medicinal plant effects and applications
- Pharmacological Effects of Medicinal Plants
- Flavonoids in Medical Research
- Pesticide Exposure and Toxicity
- Seaweed-derived Bioactive Compounds
- Morinda citrifolia extract uses
- Antioxidant Activity and Oxidative Stress
- Phytochemicals and Antioxidant Activities
- Medicinal Plants and Neuroprotection
- Estrogen and related hormone effects
Dong-A University
2020-2023
Chung-Ang University
2015
Ewha Womans University
2014
Cheju Halla University
2001-2003
Amyloid beta (Aβ) peptide, one of the most important pathogenic traits Alzheimer’s disease (AD), invokes a cascade oxidative damage and eventually leads to neuronal death. In present study, baicalein, wogonin, oroxylin A, main active flavones in Scutellaria baicalensis, were evaluated for their neuroprotective effects against Aβ25–35-stimulated damage. All tested compounds decreased Aβ25–35-induced ROS generation cell cycle arrest. particular, baicalein exhibited strongest antioxidant...
The possible role of quercetin, a naturally occurring plant flavonoid, in protecting against oxygen–glucose deprivation (OGD)-, excitotoxins-, and free radical-induced neuronal injury mouse cortical cell cultures was investigated. Pre- co-treatment with quercetin (100 μM) inhibited 50 min OGD-, 20 μM N-methyl-D-aspartate (NMDA)-, kainate-induced neurotoxicity by 36, 22, 61%, respectively. Quercetin significantly ameliorated caused buthionine sulfoximine, sodium nitroprusside, ZnCl2, FeCl2....
Rutin is the major polyphenol found in buckwheat and can downregulate inflammatory responses macrophages. However, underlying mechanism unclear. Overproduction of nitric oxide (NO) by inducible synthase (iNOS) closely correlated with inflammation pathology a variety diseases. It has been reported that rutin inhibited various pro-inflammatory mediators, including cytokine signaling lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells, suppressed production NO expression...
Reactive oxygen species (ROS) regulate various biological processes by modifying reactive cysteine residues in the proteins participating relevant signaling pathways. Identification of ROS target requires specific reagents that identify ROS-sensitive sulfhydryls differ from known alkylating agents, iodoacetamide and N-ethylmaleimide, which react nonspecifically with oxidized cysteines including sulfenic sulfinic acid. We designed synthesized a novel reagent,...
Menopause is defined as the end of a woman's menstrual cycle sustained over 12 months and caused by reduced secretion estrogen progesterone in ovaries. These hormonal changes lead to menopausal symptoms, including hot flushes, difficulty sleeping, depression osteoporosis. Hormone replacement therapy, such administration estrogen, plus phytoestrogen, nonhormonal hormone reuptake inhibitors, are used manage symptoms. In this study, estrogenic acidity Ecklonia cava (E. cava) therapeutic effect...
Commiphora molmo (Myrrh) contains various biological activities. However, the underlying molecular mechanisms in cells remain unknown. The purpose of this study was to confirm efficacy inhibiting nitric oxide (NO) production induced by lipopolysaccharides (LPS) on J774 macrophage myrrh, and additionally regulatory effects perform wound healing. Further, vascular endothelial growth factor (VEGF), phosphorylation signal transducer activator transcription3 (p-STAT3) Janus kinase 2 (p-JAK2)...