A5101960019- Ion Transport and Channel Regulation
- Neuroscience and Neuropharmacology Research
- Circadian rhythm and melatonin
- Genetics and Neurodevelopmental Disorders
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- S100 Proteins and Annexins
- Ion channel regulation and function
- Thyroid Cancer Diagnosis and Treatment
- Renal Diseases and Glomerulopathies
- Cell death mechanisms and regulation
- RNA Research and Splicing
- Asthma and respiratory diseases
- Genetic Associations and Epidemiology
- Oral microbiology and periodontitis research
- Immune Response and Inflammation
- Epigenetics and DNA Methylation
- 14-3-3 protein interactions
- Intracerebral and Subarachnoid Hemorrhage Research
- Bipolar Disorder and Treatment
- Metabolism and Genetic Disorders
- Neurotransmitter Receptor Influence on Behavior
- Mast cells and histamine
- Protease and Inhibitor Mechanisms
- Immune Cell Function and Interaction
Kyung Hee University
2014-2024
Kyung Hee University Dental Hospital
2023
Bridge University
2023
University Medical Center
2023
Kyung Hee University Medical Center
2009-2019
Emory University
2009-2010
National Institute of Allergy and Infectious Diseases
1994
A cDNA encoding a double-stranded-RNA (dsRNA)-binding protein was isolated by screening HeLa cell expression library for proteins that bind the HIV-1 Rev-responsive-element RNA. The encoded identical to TRBP, previously reported cellular binds transactivation response element (TAR) RNA of human immunodeficiency virus type 1. TRBP inhibited phosphorylation interferon-induced ribosome-associated kinase PKR and eukaryotic translation initiation factor eIF-2 alpha in transient-expression system...
Recent studies have reported that changes in gut microbiota composition could induce neuropsychiatric problems. In this study, we investigated alterations induced by early-life stress (ELS) rats subjected to maternal separation (MS; 6 h a day, postnatal days (PNDs) 1–21), along with inflammatory cytokines and tryptophan-kynurenine (TRP-KYN) metabolism, assessed the differences between sexes. High-throughput sequencing of bacterial 16S rRNA gene showed relative abundance Bacteroides genus was...
The genes were divided into seven categories according to biological function; apoptosis-related, immune response-related, signal transduction-related, cell cycle-related, growth-related, stress response-related and transcription-related genes.We compared the gene expression profiles of SNU-C4 cells between amygdalin-treated (5 mg/mL, 24 h) non-treated groups using cDNA microarray analysis. We selected downregulated in investigated mRNA levels by RT-PCR.Microarray showed that amygdalin...
Benign prostatic hyperplasia (BPH) is one of the common male diseases, which provoked by dihydrotestosterone (DHT) and androgen signals. Several studies showed that curcumin has various effects prevention treatment to diseases. We investigated whether may repress development BPH in Wistar rats. Seven weeks rats were divided into 4 groups (normal group, finasteride group; n = 8 for each group). In order induce rats, castrated testosterone was injected subcutaneously everyday (s.c., 20 mg/kg)....
The human oral microbiome refers to an ecological community of symbiotic and pathogenic microorganisms found in the cavity. cavity is a suitable environment that provides various kinds biological niches such as teeth, tongue, mucosa. gateway between external body, maintaining homeostasis, protecting mouth, preventing disease. On flip side, plays important role triggering, development, progression systemic diseases. Currently, disease diagnosis through analysis has been realized with recent...
Background/Aim: Sleep loss is proposed as a trigger for manic episodes in bipolar disorder humans. It has been shown that sleep and wakefulness can affect changes mitochondrial gene expression, oxidative phosphorylation (OXPHOS) activity, morphology the brain. In this study, we investigated alterations bioenergetic function brain of rats after 72-h rapid eye movement deprivation (REM-SD). Materials Methods: Alterations DNA (mtDNA) copy number were detected prefrontal cortex hippocampus...
Citrus fruits have been known to reduce the proliferation of many cancer cells. The antiproliferative effects reticulata Blanco (CR) extract, immature tangerine peel, on human gastric cell line SNU-668 were evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, 4,6-diamidineo-2-phenylindole staining, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling reverse transcription-polymerase chain reaction expressions BCL-2, BAX and CASP-3 genes,...
The excessive proliferation and migration of synoviocytes are well-characterized phenomena that play key roles in the pathophysiology rheumatoid arthritis (RA). Melatonin has been shown to have potent anti-proliferative effect various cancer cells such as breast prostate cells. In this study, we examined role melatonin on synoviocyte primary cultured human fibroblast-like (FLSs) by analyzing protein expression P21(CIP1) (P21) P27(KIP1) (P27), cyclin-dependent kinase inhibitors important cell...
The sodium-bicarbonate cotransporter NBCn1 (SLC4A7) is an acid-base transporter that normally moves Na(+) and HCO(3)(-) into the cell. This membrane protein sensitive to cellular systemic pH changes. We examined expression localization in brain its response chronic metabolic acidosis. Two new antibodies were generated by immunizing a rabbit guinea pig. stained neurons variety of rat regions, including hippocampal pyramidal neurons, dentate gyrus granular posterior cortical cerebellar...
Melatonin possesses a number of important biologic activities including oncostatic, anti-oxidant, and immunostimulatory actions. This study was designed to assess the effects melatonin on inflammation-related gene expression in lipopolysaccharide (LPS)-stimulated human peripheral blood mononuclear cells (PBMCs), using CombiMatrix 2K Human Inflammation chip. After pretreatment with (100 microm) for 4 hr, were incubated LPS (1 microg/mL) 24 hr. We compared profiles between LPS-treated,...
To understand the mechanism for ion transport through sodium/bicarbonate transporter SLC4A4 (NBCe1), we examined amino acid residues, within transmembrane domains, that are conserved among electrogenic Na/HCO(3) transporters but substituted with residues at corresponding site of all electroneutral transporters. Point mutants were constructed and expressed in Xenopus oocytes to assess function using two-electrode voltage clamp. Among mutants, D555E (charge-conserved substitution aspartate...
Interleukin 18 (interferon gamma-inducing factor) (IL18) is an important proinflammatory cytokine that belongs to the IL1 family. This study investigated whether IL18 single-nucleotide polymorphisms (SNPs) are associated with susceptibility alopecia areata (AA) in a Korean population. Two hundred thirty-three AA patients and 243 healthy control subjects were recruited. One promoter SNP (rs187238, -137G/C) exonic (rs549908, Ser35Ser) genotyped using direct sequencing. SNPStats, SPSS 18.0,...
Background: FOS has been implicated in the progression of renal disease including IgAN.In this study, we investigated whether polymorphisms family genes [FOS, FOSB, FOS-like antigen 1 (FOSL1), and FOSL2] were associated with immunoglobulin A nephropathy (IgAN) clinical phenotypes IgAN patients.Methods: We genotyped single nucleotide (SNPs) (rs2239615 rs7101 for FOS, rs12373539 rs2282695 rs637571 FOSL1, rs925255 FOSL2) using direct sequencing 198 patients 290 control subjects.Results: No SNPs...