A5079903122- Helicobacter pylori-related gastroenterology studies
- interferon and immune responses
- Gut microbiota and health
- Reproductive tract infections research
- Immune Cell Function and Interaction
- Reproductive Health and Contraception
- HIV Research and Treatment
- Clostridium difficile and Clostridium perfringens research
- Immunotherapy and Immune Responses
- Virology and Viral Diseases
- HIV-related health complications and treatments
- Vaccine Coverage and Hesitancy
- Acute Lymphoblastic Leukemia research
- Hepatitis C virus research
- Adolescent Sexual and Reproductive Health
- Diabetes and associated disorders
- Zoonotic diseases and public health
- Chronic Lymphocytic Leukemia Research
- T-cell and B-cell Immunology
- Systemic Lupus Erythematosus Research
- Reproductive System and Pregnancy
- Lymphoma Diagnosis and Treatment
Emory University
2020-2023
Clemson University
2023
Emory National Primate Research Center
2021-2022
Short-chain fatty acids (SCFAs) are products of bacterial fermentation that help maintain important gut functions such as maintenance the intestinal barrier, cell signaling, and immune homeostasis. The main SCFAs acetate, propionate, butyrate have demonstrated beneficial effects for host, including its importance in alleviating infections caused by pathogens
Early appearance of neutralizing antibodies during acute hepatitis C virus (HCV) infection is associated with spontaneous viral clearance. However, the longitudinal changes in antigen-specific memory B cell (MBCs) divergent HCV outcomes remain undefined. We characterized E2 glycoprotein-specific MBCs from subjects who either spontaneously resolved or progressed to chronic infection, using single-cell RNA-seq and functional assays. HCV-specific plasma chronically infected recognized multiple...
HIV associated immune activation (IA) is with increased morbidity in people living (PLWH) on antiretroviral therapy, and remains a barrier for strategies aimed at reducing the reservoir. The underlying mechanisms of IA have not been definitively elucidated, however, persistent production Type I IFNs expression ISGs considered to be one primary factors. Plasmacytoid DCs (pDCs) are major producer IFN during viral infections, highly immunomodulatory acute SIV infection, however their role...
The inability of Nef to downmodulate the CD3-T cell receptor (TCR) complex distinguishes HIV-1 from other primate lentiviruses and may contribute its high virulence. However, role this function in virus-mediated immune activation pathogenicity remains speculative. Here, we selectively disrupted activity SIVmac239 analyzed consequences for virological, immunological, clinical outcome infection rhesus macaques. CD3-TCR does not impair viral replication during acute but is associated with...
ABSTRACT Short chain fatty acids (SCFAs) are products of bacterial fermentation that help maintain important gut functions such as the intestinal barrier, signaling, and immune homeostasis. The main SCFAs acetate, propionate, butyrate have demonstrated beneficial effects for host, including importance in combatting infections caused by pathogens Clostridioides difficile . Despite potential role mitigating C. infection, their direct effect on remains unclear. Through a set vitro experiments,...
The accessory viral protein R (Vpr) is encoded by all primate lentiviruses. Vpr counteracts DNA repair pathways, modulates immune sensing, and induces cell-cycle arrest in cell culture. However, its impact vivo controversial. Here, we show that deletion of vpr associated with delayed replication kinetics, rapid innate activation, development maintenance strong B T responses, increased neutralizing activity against SIVmac239 rhesus macaques. All wild-type SIVmac239-infected animals maintained...
Although effective contraceptives are crucial for preventing unintended pregnancies, evidence suggests that their use may perturb the female genital tract (FGT). A comparative analysis of effects most common on FGT have not been evaluated in a randomized clinical trial setting. Here, we effect three long-acting contraceptive methods: depot medroxyprogesterone acetate(DMPA-IM), levonorgestrel(LNG) implant, and copper intrauterine device (Cu-IUD), endocervical host transcriptome 188 women from...
Hormonal contraceptives (HCs) are vital in managing the reproductive health of women. However, HC usage has been linked to perturbations cervicovaginal immunity and increased risk sexually transmitted infections. Here, we evaluated impact three HCs on environment using high-throughput transcriptomics. From 2015 2017, 130 adolescent females aged 15–19 years were enrolled into a substudy UChoose, single-site, open-label randomized, crossover trial (NCT02404038) randomized injectable...
The accessory viral protein R (Vpr) is encoded by all primate lentiviruses. Vpr counteracts DNA repair pathways, modulates immune sensing, and induces cell-cycle arrest in cell culture. However, its impact vivo controversial. Here, we show that deletion of vpr associated with delayed replication kinetics, rapid innate activation, development maintenance strong B T responses, increased neutralizing activity against SIVmac239 rhesus macaques. All wild-type infected animals maintained high...