A5013758925- T-cell and B-cell Immunology
- Immune Response and Inflammation
- Mesenchymal stem cell research
- Immune Cell Function and Interaction
- Single-cell and spatial transcriptomics
- IL-33, ST2, and ILC Pathways
- Biomarkers in Disease Mechanisms
- Psoriasis: Treatment and Pathogenesis
- Cancer Cells and Metastasis
- Inflammasome and immune disorders
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Microfluidic and Bio-sensing Technologies
- Hematopoietic Stem Cell Transplantation
- Influenza Virus Research Studies
- HIV Research and Treatment
Children's Healthcare of Atlanta
2023-2024
Emory University
2022-2024
Aflac (United States)
2023
Oglethorpe University
2023
Emory National Primate Research Center
2021
Severe influenza kills tens of thousands individuals each year, yet the mechanisms driving lethality in humans are poorly understood. Here we used a unique translational model lethal H5N1 cynomolgus macaques that utilizes inhalation small-particle virus aerosols to define disease. RNA sequencing lung tissue revealed an intense interferon response within two days infection resulted widespread expression interferon-stimulated genes, including inflammatory cytokines and chemokines. Macaques...
HIV associated immune activation (IA) is with increased morbidity in people living (PLWH) on antiretroviral therapy, and remains a barrier for strategies aimed at reducing the reservoir. The underlying mechanisms of IA have not been definitively elucidated, however, persistent production Type I IFNs expression ISGs considered to be one primary factors. Plasmacytoid DCs (pDCs) are major producer IFN during viral infections, highly immunomodulatory acute SIV infection, however their role...
Abstract Obesity is associated with increased skin inflammation and a major risk factor for psoriasis, raising the question of how obesity disrupts regulatory mechanisms that keep in check at steady state. We found was enriched unique subset CD4 +Foxp3 +regulatory T cells (Tregs), which critical to limit IL-17A-mediated psoriatic inflammation. Diet-induced obesity, however, resulted significant reduction this Tregs corresponding loss control over Mechanistically, specific Treg population...