A5080872978- HIV Research and Treatment
- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- COVID-19 Clinical Research Studies
- Immune cells in cancer
- RNA Research and Splicing
- Inflammasome and immune disorders
- HIV/AIDS Research and Interventions
- Ophthalmology and Visual Health Research
- HIV/AIDS drug development and treatment
- Intraocular Surgery and Lenses
- Ophthalmology and Visual Impairment Studies
- Protein Degradation and Inhibitors
- Adipokines, Inflammation, and Metabolic Diseases
- SARS-CoV-2 and COVID-19 Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological disorders and treatments
- Cancer-related gene regulation
- Long-Term Effects of COVID-19
- Parkinson's Disease Mechanisms and Treatments
- Cytomegalovirus and herpesvirus research
- Immunotherapy and Immune Responses
- Extracellular vesicles in disease
- T-cell and B-cell Immunology
Emory University
2020-2023
The University of Melbourne
2018-2022
Peter Doherty Institute
2018-2022
AbbVie (United States)
2022
Emory National Primate Research Center
2021
UNSW Sydney
2003
The immunopathological mechanisms driving the development of severe COVID-19 remain poorly defined. Here, we utilize a rhesus macaque model acute SARS-CoV-2 infection to delineate perturbations in innate immune system. initiates rapid infiltration plasmacytoid dendritic cells into lower airway, commensurate with IFNA production, natural killer cell activation, and significant increase blood CD14
Abstract Background The burden of Parkinson’s disease (PD) worsens with progression. However, the lack objective and uniform classification challenges our understanding incremental in patients advanced (APD) suboptimal medication control. 5–2-1 criteria was proposed by clinical consensus to identify advancing PD. Our evaluate screening accuracy burden, healthcare resource utilization (HCRU), humanistic PD meeting criteria. Methods Data were drawn from Adelphi Disease Specific Program (DSP™),...
Different classes of latency reversing agents (LRAs) are being evaluated to measure their effects in reactivating HIV replication from latently infected cells. A limited number studies have demonstrated additive LRAs with the viral protein Tat initiating transcription, but less is known about how interact Tat, particularly through basic residues that may be post-translationally modified alter behaviour for processive transcription and co-transcriptional RNA processing.Here we show various...
HIV associated immune activation (IA) is with increased morbidity in people living (PLWH) on antiretroviral therapy, and remains a barrier for strategies aimed at reducing the reservoir. The underlying mechanisms of IA have not been definitively elucidated, however, persistent production Type I IFNs expression ISGs considered to be one primary factors. Plasmacytoid DCs (pDCs) are major producer IFN during viral infections, highly immunomodulatory acute SIV infection, however their role...
HIV-1 Tat protein is essential for virus production. RNA-binding proteins that facilitate production may be absent or downregulated in resting CD4+ T-cells, the main reservoir of latent HIV people with (PWH) on antiretroviral therapy (ART). In this study, we examined role expression and control productive infection. Affinity purification coupled mass spectrometry analysis was used to detect binding partners MS2-tagged tat mRNA a T cell-line model latency. The effect knockdown overexpression...
Abstract The COVID-19 pandemic remains a global health crisis, yet, the immunopathological mechanisms driving development of severe disease remain poorly defined. Here, we utilize rhesus macaque (RM) model SARS-CoV-2 infection to delineate perturbations in innate immune system during acute using an integrated systems analysis. We found that initiated rapid infiltration (two days post infection) plasmacytoid dendritic cells into lower airway, commensurate with IFNA production, natural killer...
Latent HIV-1 provirus in infected individuals on suppressive therapy does not always remain transcriptionally silent. Both LTR and human gene promoter derived transcriptional events can contribute sequences to the mRNA produced cell. In addition, chimeric cellular:HIV arise through readthrough transcription aberrant splicing. Using target enrichment coupled Illumina Mi-Seq PacBio RS II platforms, we show that 3' activation is frequent latently cells from both CCL19-induced primary cell model...
Effective therapeutics aimed at mitigating COVID-19 symptoms are urgently needed. SARS-CoV-2 induced hypercytokinemia and systemic inflammation associated with disease severity. Baricitinib, a clinically approved JAK1/2 inhibitor potent anti-inflammatory properties is currently being investigated in human clinical trials. Recent reports suggest that baricitinib may also have antiviral activity limiting viral endocytosis. Here, we the immunologic virologic efficacy of rhesus macaque model...
The importance of early vision care in the prevention and treatment amblyopia is clear from an abundance literature on visual development. Optometrists possess necessary skills to detect manage amblyogenic factors thus have important role play paediatric assessment management. present study investigates that optometrists New South Wales are taking methods strategies used this role.Questionnaires were sent 400 practising Wales; 179 completed questionnaires returned.Our findings reveal a...
Analysis of circulating cell-free DNA (cfDNA) methylation abnormalities has emerged as a promising strategy for detecting various diseases, including cancer. While single-biomarker approaches may lack sensitivity, comprehensive next-generation sequencing (NGS) can be cumbersome and expensive. Multiplex qPCR assays offer practical intermediate solution by providing accurate, accessible, affordable biomarker detection. In this study, we demonstrated process developing multiplex...