Jennifer Wood
A5084200499- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- Long-Term Effects of COVID-19
- HIV Research and Treatment
- Animal Virus Infections Studies
- Mosquito-borne diseases and control
- Malaria Research and Control
- Intensive Care Unit Cognitive Disorders
- COVID-19 epidemiological studies
- vaccines and immunoinformatics approaches
- Immune Cell Function and Interaction
- Bird parasitology and diseases
- Primate Behavior and Ecology
- Animal Behavior and Welfare Studies
- Respiratory Support and Mechanisms
- Respiratory viral infections research
- Human-Animal Interaction Studies
- Viral gastroenteritis research and epidemiology
- COVID-19 Pandemic Impacts
- COVID-19 and healthcare impacts
- HIV/AIDS Research and Interventions
- Cytomegalovirus and herpesvirus research
- Immune responses and vaccinations
- Kawasaki Disease and Coronary Complications
Emory University
2015-2025
SUNY Brockport
2025
Medway NHS Foundation Trust
2024
Emory National Primate Research Center
2023
RELX Group (United Kingdom)
2023
University of Cambridge
2020-2022
Addenbrooke's Hospital
2022
NIHR Clinical Research Network
2021
National Institute for Health Research
2021
National Records of Scotland
2021
Abstract The SARS-CoV-2 Omicron BA.1 variant emerged in 2021 1 and has multiple mutations its spike protein 2 . Here we show that the of a higher affinity for ACE2 compared with Delta, marked change antigenicity increases Omicron’s evasion therapeutic monoclonal vaccine-elicited polyclonal neutralizing antibodies after two doses. mRNA vaccination as third vaccine dose rescues broadens neutralization. Importantly, antiviral drugs remdesivir molnupiravir retain efficacy against BA.1....
Abstract Although two-dose mRNA vaccination provides excellent protection against SARS-CoV-2, there is little information about vaccine efficacy variants of concern (VOC) in individuals above eighty years age 1 . Here we analysed immune responses following with the BNT162b2 2 elderly participants and younger healthcare workers. Serum neutralization levels binding IgG or IgA after first dose were lower older individuals, a marked drop over old. Sera from showed potency B.1.1.7 (Alpha),...
Generating tier 2 HIV-neutralizing antibody (nAb) responses by immunization remains a challenging problem, and the immunological barriers to induction of such with Env immunogens remain unclear. Here, some rhesus monkeys developed autologous nAbs upon HIV trimer (SOSIP.v5.2) whereas others did not. This was not because trimers were immunologically silent all made similar ELISA-binding responses; key difference nAb versus non-nAb responses. We explored combining suite techniques, including...
Ongoing SARS-CoV-2 vaccine development is focused on identifying stable, cost-effective, and accessible candidates for global use, specifically in low middle-income countries. Here, we report the efficacy of a rapidly scalable, novel yeast expressed specific receptor-binding domain (RBD) based rhesus macaques. We formulated RBD immunogen alum, licensed an emerging alum adsorbed TLR-7/8 targeted, 3M-052-alum adjuvants. The RBD+3M-052-alum adjuvanted promoted better binding effector...
Omicron SARS-CoV-2 variants escape vaccine-induced neutralizing antibodies and cause nearly all current COVID-19 cases. Here, we compared the efficacy of three booster vaccines against BA.5 challenge in rhesus macaques: mRNA-1273, Novavax ancestral spike protein vaccine (NVX-CoV2373), or BA.1 version (NVX-CoV2515). All induced a strong cross-reactive binding antibody changed immunoglobulin G (Ig) dominance from IgG1 to IgG4 serum. also comparable responses multiple concern, including BQ.1.1,...
SARS-CoV-2 vaccines should induce broadly cross-reactive humoral and T cell responses to protect against emerging variants of concern (VOCs). Here, we inactivated the furin cleavage site (FCS) spike expressed by a modified vaccinia Ankara (MVA) virus vaccine (MVA/SdFCS) found that FCS inactivation markedly increased binding human ACE2. After vaccination mice, MVA/SdFCS induced eightfold higher neutralizing antibodies compared with MVA/S, which without inactivation, protected Beta variant. We...
Type I interferons (IFN-I) are critical mediators of innate control viral infections but also drive the recruitment inflammatory cells to sites infection, a key feature severe coronavirus disease 2019. Here, IFN-I signaling was modulated in rhesus macaques (RMs) before and during acute SARS-CoV-2 (severe respiratory syndrome 2) infection using mutated IFN-α2 (IFN-modulator; IFNmod), which has previously been shown reduce binding endogenous IFN-I. IFNmod treatment uninfected RMs observed...
Open Educational Resources (OER) have been adopted by growing numbers in higher education during the last two decades. Online repositories contain a myriad of OER content, learning objects, and activities. This article presents six case studies from both new experienced instructors across multiple disciplines at single institution. It outlines varying motivations for selecting OER, problems encountered, possible solutions according to when, how why started their individual journeys. Closer...
The latent viral reservoir remains the major barrier to HIV cure, placing burden of strict adherence antiretroviral therapy (ART) on people living with prevent recrudescence viremia. For infants perinatally acquired HIV, is anticipated be a lifelong need. In this study, we tested hypothesis that administration ART and Envelope-specific rhesus-derived IgG1 monoclonal antibodies (RhmAbs) or without IL-15 superagonist N-803 early in infection would limit establishment SIV-infected infant rhesus...
The continued evolution of SARS-CoV-2 variants capable subverting vaccine and infection-induced immunity suggests the advantage a broadly protective against betacoronaviruses (β-CoVs). Recent studies have isolated monoclonal antibodies (mAbs) from recovered-vaccinated donors neutralizing many other β-CoVs. Many these mAbs target conserved S2 stem region spike protein, rather than receptor binding domain contained within S1 primarily targeted by current vaccines. One S2-directed mAbs, CC40.8,...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of disease 2019 (COVID-19), has caused widespread morbidity and mortality since its onset in late 2019. Here, we demonstrate that prior infection with human cytomegalovirus (HCMV) substantially increases SARS-CoV-2 vitro. HCMV is a common herpesvirus carried by 40%-100% population, which can reactivate lung under inflammatory conditions, such as those resulting from infection. We show both endothelial...
Understanding viral rebound in pediatric HIV-1 infection may inform the development of alternatives to lifelong antiretroviral therapy (ART) achieve remission. We thus investigated after analytical treatment interruption (ATI) 10 infant macaques orally infected with SHIV.C.CH505 and treated long-term ART. Rebound viremia was detected within 7 35 days ATI 9 animals, posttreatment control seen 5 Mamu-A*01+ macaques. Single-genome sequencing revealed that initial virus similar DNA present CD4+...
Histopathological data collected from patients with severe malaria have been instrumental for studying pathogenesis. Animal models of are critical to complement such studies. Here, the histopathological changes observed in a rhesus macaque and complicated Plasmodium cynomolgi reported. The animal presented thrombocytopenia, anemia, hyperparasitemia during acute infection. was given subcurative antimalarial treatment, fluid support, blood transfusion treat clinical complications, but at time...
Kra monkeys (Macaca fascicularis), a natural host of Plasmodium knowlesi, control parasitaemia caused by this parasite species and escape death without treatment. Knowledge the disease progression resilience in kra will aid effective use to study mechanisms malaria. This longitudinal aimed define clinical, physiological pathological changes infected with P. which could explain their resilient phenotype.
Abstract Background Compatible pair housing of macaques in research settings increases species‐typical behaviors and facilitates beneficial social buffering. It is not yet established whether these benefits are maintained after intrafacility transfer domestic quarantine, which two stressors that can lead to behavioral clinical abnormalities. Methods We evaluated 40 adolescent male rhesus who were single‐ or pair‐housed immediately following an transfer. measured behavior, fecal cortisol,...
Abstract Type-I interferons (IFN-I) are critical mediators of innate control viral infections, but also drive recruitment inflammatory cells to sites infection, a key feature severe COVID-19. Here, and for the first time, IFN-I signaling was modulated in rhesus macaques (RMs) prior during acute SARS-CoV-2 infection using mutated IFNα2 (IFN-modulator; IFNmod), which has previously been shown reduce binding endogenous IFN-I. In SARS-CoV-2-infected RMs, IFNmod reduced both antiviral ISGs....
The "shock and kill" strategy for HIV-1 cure incorporates latency-reversing agents (LRA) in combination with interventions that aid the host immune system clearing virally reactivated cells. LRAs have not yet been investigated pediatric clinical or preclinical studies. Here, we evaluated an inhibitor of apoptosis protein (IAP) (IAPi), AZD5582, activates noncanonical NF-κB (ncNF-κB) signaling pathway to reverse latency. Ten weekly doses AZD5582 were intravenously administered at 0.1 mg/kg...
Plasmodium knowlesi poses a health threat throughout Southeast Asian communities and currently causes most cases of malaria in Malaysia. This zoonotic parasite species has been studied Macaca mulatta (rhesus monkeys) as model for severe malarial infections, chronicity, antigenic variation. The phenomenon variation was first recognized during rhesus monkey infections. -encoded variant proteins were discovered this found to be expressed at the surface infected erythrocytes, then named...