A5091146390- Angiogenesis and VEGF in Cancer
- Lipid metabolism and disorders
- Cardiac and Coronary Surgery Techniques
- Lymphatic System and Diseases
- Biomarkers in Disease Mechanisms
- Mesenchymal stem cell research
- Adipokines, Inflammation, and Metabolic Diseases
- COVID-19 Clinical Research Studies
- Congenital heart defects research
- Single-cell and spatial transcriptomics
- Cancer survivorship and care
- Cancer, Lipids, and Metabolism
- SARS-CoV-2 and COVID-19 Research
- T-cell and B-cell Immunology
- Cardiac Fibrosis and Remodeling
- Inflammasome and immune disorders
- Cancer, Stress, Anesthesia, and Immune Response
- Inflammatory Biomarkers in Disease Prognosis
- Cardiovascular Function and Risk Factors
- Long-Term Effects of COVID-19
- Immunotherapy and Immune Responses
- Histone Deacetylase Inhibitors Research
- Inflammation biomarkers and pathways
- HIV Research and Treatment
Emory National Primate Research Center
2021
Emory University
2016-2020
Cancer Research And Biostatistics
2018
Winship Cancer Institute
2017
Endogenous regenerative capacity, assessed as circulating progenitor cell (PC) numbers, is an independent predictor of adverse outcomes in patients with cardiovascular disease. However, their predictive role heart failure (HF) remains controversial. We the relationship between number PCs and pathogenesis severity HF impact on incident events.We recruited 2049 adults which 651 had diagnosis. were enumerated by flow cytometry CD45med+ blood mononuclear cells expressing CD34, CD133, vascular...
Background Lower levels of circulating progenitor cells (PCs) reflect impaired endogenous regenerative capacity and are associated with aging, vascular disease, poor outcomes. Whether biologic sex hormones influence PC numbers remains a subject controversy. We sought to determine differences in PCs both healthy persons patients coronary artery their association hormone levels. Methods Results In 642 participants (mean age 48 years, 69% women, 23% black) free from cardiovascular we measured...
Rationale: Circulating progenitor cells (CPCs) mobilize in response to ischemic injury, but their predictive value remains unknown acute coronary syndrome (ACS). Objective: We aimed investigate the number of CPCs ACS compared with those stable artery disease (CAD), relationship between bone marrow PCs and CPCs, whether CPC counts predict mortality patients ACS. Methods Results: In 2028 patients, 346 had unstable angina, 183 an myocardial infarction (AMI), remaining 1499 CAD. Patients were...
Rationale: Blacks compared with whites have a greater risk of adverse cardiovascular outcomes. Impaired regenerative capacity, measured as lower levels circulating progenitor cells (CPCs), is novel determinant outcomes; however, little known about racial differences in CPCs. Objective: To investigate the number CPCs, PC-mobilizing factors, PC mobilization during acute myocardial infarction and predictive value CPC counts blacks whites. Methods Results: CPCs were enumerated by flow cytometry...
HIV associated immune activation (IA) is with increased morbidity in people living (PLWH) on antiretroviral therapy, and remains a barrier for strategies aimed at reducing the reservoir. The underlying mechanisms of IA have not been definitively elucidated, however, persistent production Type I IFNs expression ISGs considered to be one primary factors. Plasmacytoid DCs (pDCs) are major producer IFN during viral infections, highly immunomodulatory acute SIV infection, however their role...
A recent publication by Mekonnen et al. demonstrated that among women with non-obstructive coronary artery disease, higher levels of circulating progenitor cells in the blood (CPC), were associated impaired flow reserve [1]. We performed a quality control assessment stability samples stored at 4 °C, to determine time period during which can be analyzed and yield consistent data for cell content. Healthy volunteers (n=6) recruited underwent phlebotomy, was EDTA tubes °C. Flow cytometry...
Effective therapeutics aimed at mitigating COVID-19 symptoms are urgently needed. SARS-CoV-2 induced hypercytokinemia and systemic inflammation associated with disease severity. Baricitinib, a clinically approved JAK1/2 inhibitor potent anti-inflammatory properties is currently being investigated in human clinical trials. Recent reports suggest that baricitinib may also have antiviral activity limiting viral endocytosis. Here, we the immunologic virologic efficacy of rhesus macaque model...
Familial hypercholesterolemia (FH) is a genetic disease with very high levels of circulating low density lipoprotein cholesterol (LDL-C) that leads to accelerated atherosclerosis. Lipoprotein apheresis an effective treatment option for patients FH and results in reduced cardiovascular morbidity mortality. Circulating progenitor cells (CPCs) are markers overall vascular health diminished have been associated decreased reparative potential worse outcomes. We assessed the short-term change CPC...