A5020169072- Cardiac Valve Diseases and Treatments
- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Electrospun Nanofibers in Biomedical Applications
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Aortic Disease and Treatment Approaches
- Cardiovascular Function and Risk Factors
- Infective Endocarditis Diagnosis and Management
- Cardiac Structural Anomalies and Repair
- Wound Healing and Treatments
- Aortic aneurysm repair treatments
- Liver Disease and Transplantation
- Mechanical Circulatory Support Devices
- Heart Failure Treatment and Management
- Venous Thromboembolism Diagnosis and Management
- Acute Myocardial Infarction Research
- Cardiac and Coronary Surgery Techniques
- Cardiac electrophysiology and arrhythmias
- Diabetes Treatment and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Arrest and Resuscitation
- Congenital Heart Disease Studies
- Protease and Inhibitor Mechanisms
- Peptidase Inhibition and Analysis
Chang Gung University
2016-2025
Chang Gung Memorial Hospital
2016-2025
Linkou Chang Gung Memorial Hospital
2015-2024
Ministry of Health Labour and Welfare
2024
Stanford Medicine
2018
Tao Yuan General Hospital
2015-2016
National Tsing Hua University
2015
Memorial Hospital of South Bend
2005-2011
Tri-Service General Hospital
2008
Chiayi Chang Gung Memorial Hospital
2006
Patients with chronic kidney disease have abnormal energy expenditure and metabolism. The mechanisms underlying altered in uremia are unknown remain to be elucidated. Irisin is a peroxisome proliferator-activated receptor γ coactivator 1-α–dependent myokine, it increases the absence of changes food intake or activity. We hypothesize that patients irisin levels. measured resting levels 38 stage 5 19 age- sex-matched normal subjects. Plasma were significantly decreased (58.59%; 95% CI...
This work developed biodegradable nanofibrous drug-eluting membranes that provided sustained release of metformin for repairing wounds associated with diabetes. To prepare the membranes, poly-d-l-lactide-glycolide (PLGA) and were first dissolved in 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) spun into by electrospinning. An elution method an HPLC assay utilized to characterize vivo vitro rates pharmaceuticals from membranes. The released high concentrations more than three weeks. Moreover,...
More than half of diabetic wounds demonstrate clinical signs infection at presentation and lead to poor outcomes. This work develops coaxial sheath-core nanofibrous poly(lactide-co-glycolide) (PLGA) scaffolds that are loaded with bioactive antibiotics platelet-derived growth factor (PDGF) for the repair infectious wounds. PDGF PLGA/antibiotic solutions were pumped, respectively, into two independent capillary tubings electrospinning prepare biodegradable nanofibers. Spun sustainably released...
Atrial fibrillation (AF)-associated embolic stroke is preventable, and AF detection may help to prevent in subjects with paroxysmal AF. We aimed evaluate the performance of smartwatch photoplethysmography (PPG) feasibility ambulatory monitoring for daily life.Consecutive who underwent Holter electrocardiogram (ECG) or burden evaluation were enrolled. The participants 24 hours simultaneous ECG continuous PPG recording using a Garmin smartwatch. signals processed noise rejection, beat...
Abstract Background Asprosin is a novel fasting glucogenic adipokine discovered in 2016. induces rapid glucose releases from the liver. However, its molecular mechanisms and function are still unclear. Adaptation of energy substrates fatty acid to recently considered therapeutic target heart failure treatment. We hypothesized that asprosin able modulate cardiac mitochondrial functions has important prognostic implications dilated cardiomyopathy (DCM) patients. Methods prospectively enrolled...
<h3>Importance</h3> The associations between long-term treatment of aortic dissection with various medications and late patient outcomes are poorly understood. <h3>Objective</h3> To compare after use β-blockers, angiotensin-converting enzyme inhibitors (ACEIs), angiotensin receptor blockers (ARBs), or other antihypertensive (controls) among patients treated for dissection. <h3>Design, Setting, Participants</h3> This population-based retrospective cohort study using the National Health...
Introduction: Slow wound repair in diabetes is a serious adverse event that often results loss of limb or disability. An advanced and encouraging vehicle wanted to enhance clinically applicable diabetic care. Nanofibrous insulin/vildagliptin core-shell biodegradable poly (lactic-co-glycolic acid) (PLGA) scaffolds prolong the effective drug delivery vildagliptin insulin for wounds were prepared. Methods: To fabricate nanofibrous membranes, mixture with PLGA, solution pumped via separate pumps...
Transthoracic echocardiography plays a crucial role in clinical diagnosis and is increasingly being used around the world. Comprehensive echocardiographic examinations require accurate measurements operators to have excellent technical skills. Despite availability of several published guidelines, absence recommended operational manuals daily practice has resulted significant variation content reports across different medical institutions. This variability created communication barriers...
Background: Invasive coronary angiography is the gold standard for assessing in-stent restenosis (ISR) in patients with artery disease. However, predictive value of non-invasive Tissue Doppler Imaging (TDI) to evaluate ISR has not been studied extensively. Methods: A total 41 (19 acute myocardial infarction and 22 stable angina pectoris) who received percutaneous intervention (PCI) were enrolled study. Time-to-peak velocities (TpV) 12 non-apical segments left ventricle, by pulse wave TDI...
Objectives. Hyperuricaemia has been linked to atherosclerosis; however, there is limited evidence about its association with arterial stiffness and cardiac hypertrophy, which are associated adverse cardiovascular outcomes. We studied the of hyperuricaemia an increased risk hypertrophy in a population participating health-screening programme.
This study aimed to determine clinical utility of genotype-guided dosing for warfarin in Han-Chinese.A total 320 patients were randomly assigned International Warfarin Pharmacogenetic Consortium algorithm, Taiwan algorithm and optimal care arms. The primary outcome the was percentage time therapeutic range during first 90 days treatment.The group 2 weeks significantly higher than groups. difference no longer observed after 4 weeks. No excessive anticoagulation (international normalized ratio...
Background Dialysis‐requiring acute kidney injury (D‐AKI) is a major complication of cardiovascular surgery that results in worse prognosis. However, the incidence and impacts D‐AKI different types cardiac surgeries have not been fully investigated. Methods Results Patients admitted for between July 1, 2004, December 31, 2013, were identified from National Health Insurance Research Database Taiwan. The patients grouped into (n=3089) non–D‐AKI (n=42 151) groups. outcome was all‐cause...
Abstract Genome-wide association studies have shown that variants in fat mass and obesity-associated ( FTO ) gene are robustly associated with body index obesity. These also end stage renal disease all-cause mortality chronic kidney diseases. However, the exact role of kidneys is currently unknown. Here we show expression increased after ureteral obstruction fibrosis. Deficiency attenuates fibrogenic responses induced by kidney. Renal tubular cells deficient produce less α-SMA TGF-β...