A5058638443- Mast cells and histamine
- Immune Cell Function and Interaction
- Asthma and respiratory diseases
- Immunotherapy and Immune Responses
- Hepatitis C virus research
- T-cell and B-cell Immunology
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Monoclonal and Polyclonal Antibodies Research
- Long-Term Effects of COVID-19
- Cancer Immunotherapy and Biomarkers
- Pharmacological Effects of Natural Compounds
- Respiratory viral infections research
- Chemical Synthesis and Analysis
- Urticaria and Related Conditions
- Systemic Lupus Erythematosus Research
- HIV Research and Treatment
- Cancer, Stress, Anesthesia, and Immune Response
- Chemokine receptors and signaling
- Diabetes and associated disorders
- Liver Disease Diagnosis and Treatment
- Immune cells in cancer
- Immunodeficiency and Autoimmune Disorders
- Amino Acid Enzymes and Metabolism
- HIV/AIDS Research and Interventions
Dalhousie University
2010-2025
Nova Scotia Health Authority
2024
Izaak Walton Killam Health Centre
2017-2021
Bipar
2010
Memorial University of Newfoundland
2004-2006
Several TLR agonists are effective in tumor immunotherapy, but their early innate mechanisms of action, particularly those TLR2 agonists, unclear. Mast cells abundant surrounding solid tumors where they often protumorigenic and enhance angiogenesis. However, antitumor roles for mast have also been documented. The impact may be dependent on activation status mediator release different tumors. Using an orthotopic melanoma model wild-type C57BL/6 cell-deficient Kit(W-sh/W-sh) mice a...
Studies aimed at elucidating the immunological and prognostic significance of HLA-DR expression on breast carcinoma cells have yielded contradictory results. To expand previous studies, we investigated associations tumor cell its related co-chaperones, invariant chain (Ii) HLA-DM, with infiltrating inflammatory cells, in situ cytokine mRNA levels prognosis outcome 112 patients a median follow-up 59 months. While majority HLA-DR+ tumors co-express Ii, only minority express HLA-DM. Tumor...
BackgroundRespiratory syncytial virus (RSV) causes severe respiratory tract infections, which might have a role in the development of airway hyperreactivity. Mast cells are important effector allergy, with sentinel cell roles host defense. However, mast response to RSV infection is unknown.ObjectiveHuman responses were investigated view better understanding RSV-induced disease.MethodsHuman cord blood–derived and HMC-1 line exposed or UV-inactivated RSV. Viral gene protein expression...
Purpose Many individuals with inborn errors of immunity (IEIs) have poor humoral immune (HI) vaccine responses. Only a few studies examined specific cell-mediated (CMI) responses to coronavirus disease 2019 (COVID-19) vaccines in this population. Therefore, the purpose study was examine HI and CMI up 6 months post-COVID-19 dose 3 adults IEIs. Methods A multi-center prospective observational conducted across Canada collect severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-specific...
Histamine receptor 2 (H2) antagonists are widely used clinically for the control of gastrointestinal symptoms, but also impact immune function. They have been reported to reduce tumor growth in established colon and lung cancer models. has modify populations myeloid-derived suppressor cells (MDSCs). We examined H2 antagonist ranitidine, on both myeloid cell development spread, three distinct models breast that highlight different stages progression. Oral ranitidine treatment significantly...
Background: The histamine receptor 2 antagonist ranitidine is a commonly used, non-prescription, medication. It limits the development, growth and metastasis of breast cancers in mouse models disease. In current study, we examined role B cells this response, impact on development anti-tumor antibodies subpopulations natural killer using murine cancer models. Methods: Peripheral blood granulocyte populations were assessed both E0771-GFP 4T1 orthotopic tumor bearing mice by evaluation stained...
Abstract The biologic and prognostic significance of HLA‐DR expression T‐cell infiltration in breast carcinoma are presently controversial. To test the hypothesis that these factors influenced by particular HLA‐DRB alleles, 52 tumor samples, composed 26 DRB1*04 non‐DRB1*04 tumors, were assessed using immunohistochemistry for DR its associated invariant chain (Ii) infiltrating CD3 + T cells. While cells was significantly with infiltration, tumors more frequently Ii contained smaller...
Abstract Histamine receptor 2 (H2R) blockade is commonly used in patients with gastric, duodenal ulcers or gastroesophageal reflux disease. Beyond the gastrointestinal tract, H2R expressed by multiple immune cells, yet little known about immunomodulatory effects of such treatment. Clinical reports have associated leukopenia, neutropenia, and myelosuppression, has been shown to provide clinical benefit certain cancer settings. To systematically assess on key parameters, a single-center,...
Abstract Background Mast cells are resident immune effector cells, often studied in the context of allergic disease. Found substantial numbers at sites potential infection they increased angiogenesis and can be pivotal for sensing clearance a variety pathogens. Interferons (IFNs) cytokines that critical host defence against intracellular Increased levels IFNs observed during viral autoimmune diseases. also widely used therapeutically have been examined therapy severe asthma. Objective To...
The SARS-CoV-2 (Severe Acute Respiratory Syndrome coronavirus 2) has led to more than 165 million COVID-19 cases and >3.4 deaths worldwide. Epidemiological analysis revealed that the risk of developing severe increases with age. Despite a disproportionate number older individuals long-term care facilities being affected by COVID-19, very little is understood about immune responses development humoral immunity in extremely old person after infection. Here we conducted serological study...
Abstract Histamine has multiple immunomodulatory roles that impact innate and acquired immunity. receptor antagonists are widely used clinically to treat allergic disease gastrointestinal disorders, but their ability alter effective immune function breast tumors is unknown. We hypothesized histamine antagonist treatment could in mouse models of cancer, therefore altering the growth spread cancer. Two injectable tumor (the 4T1-BALB/c E0771-C57BL/6 model) a spontaneous cancer model (STK-/-/NIC...
Abstract Background The SARS-CoV-2 (Severe Acute Respiratory Syndrome coronavirus 2) has led to more than 114 million COVID-19 cases and >2.5 deaths worldwide. Epidemiological analysis revealed that the risk of developing severe increases with age. Despite a disproportionate number older individuals long-term care facilities being affected by COVID-19, very little is understood about immune responses development humoral immunity in extremely old person after infection. Here we...
Abstract Mast cells are abundant surrounding solid tumors where they typically promote angiogenesis and enhance tumor growth metastasis. In the context of infection, mast respond to pathogens via innate immune receptors, including TLR, produce mediators which aid host defense cell recruitment. Some TLR agonists effective in immunotherapy but role their mechanism action is unclear. Using a melanoma model wild-type C57BL/6 deficient KitW-sh/W-sh mice, were shown be crucial for TLR2-agonist...
Mast cells are potent effector abundant at the growing edge of solid tumors, where they can enhance angiogenesis. stimulated with Toll‐like receptor‐2 (TLR2) activator Pam 3 CSK 4 lipopeptide (LP) secrete angiostatic chemokines. We hypothesized that LP‐stimulated mast would have anti‐tumor potential. LP‐activated bone marrow derived cellls (BMMC) significantly inhibited growth B16.F10 melanoma (n=10, P=0.0195 ) and LLC1 Lewis lung carcinoma (n=9, P=0.0078 ), in Matrigel plugs vivo . The...