A5101516730- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- Advanced Breast Cancer Therapies
- Cancer Treatment and Pharmacology
- RNA modifications and cancer
- Prostate Cancer Treatment and Research
- Cancer, Hypoxia, and Metabolism
- Pharmacological Effects of Natural Compounds
- Nutrition, Genetics, and Disease
- Cancer-related gene regulation
- Ginseng Biological Effects and Applications
- Genetic Associations and Epidemiology
- COVID-19 Impact on Reproduction
- Testicular diseases and treatments
- Reproductive Biology and Fertility
- Nutritional Studies and Diet
- Sphingolipid Metabolism and Signaling
- Asthma and respiratory diseases
- Bladder and Urothelial Cancer Treatments
- Sinusitis and nasal conditions
- Medicinal Plants and Bioactive Compounds
- Facial Trauma and Fracture Management
Mudanjiang Normal University
2024
First Affiliated Hospital of Nanchang University
2024
Nanchang University
2023-2024
Guangdong Medical College
2023-2024
Sichuan University
2020-2024
State Key Laboratory of Oral Diseases
2020-2024
Affiliated Hospital of Guangdong Medical College Hospital
2024
Shenzhen University
2019-2023
Dian Diagnostics (China)
2022-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
PolyA– RNAs have not been widely analyzed in human pre-implantation embryos due to the scarcity of materials. In particular, circular RNA (circRNA), a novel type polyA– RNA, has characterized during development. We systematically analyze polyA+ messenger (mRNAs) and individual oocytes using SUPeR-seq. de novo identify 10,032 circRNAs from 2974 hosting genes. Most these are developmentally stage-specific dynamically regulated. Many them maternally expressed, implying their potentially...
Somatic cell nuclei of giant pandas can dedifferentiate in enucleated rabbit ooplasm, and the reconstructed eggs develop to blastocysts. In order observe whether these interspecies cloned embryos implant uterus an animal other than panda, we transferred approximately 2300 panda-rabbit into 100 synchronized recipients, none became pregnant. another approach, cotransferred both cat-rabbit oviducts 21 cat recipients. Fourteen recipients exhibited estrus within 35 days; five 43–48 days after...
Background/Aims: Treatment options for metastatic castrate-resistant prostate cancer (mCRPC) are limited and typically centered on paclitaxel-based chemotherapy. In this study, we aimed to evaluate whether miR-34a attenuates chemoresistance paclitaxel by regulating target genes associated with drug resistance. Methods: We used data from The Cancer Genome Atlas compare expression levels in (PC) tissues normal tissues. effects of inhibition overexpression PC proliferation were evaluated vitro...
Chemoresistance is largely responsible for relapses of bladder cancer during clinical therapy. However, the molecular mechanisms involved in chemoresistance are unclear. Growing evidence supports theory that microRNAs (miRNAs) play an important role chemotherapeutic drug resistance because they downregulated many malignancies have been implicated regulation diverse processes cells. More specifically, extent and precise mechanism involvement miR-34as to epirubicin (EPI) treatment remains...
An outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) occurred in China towards the end 2019, and has spread rapidly ever since. Previous studies showed that some virus could affect reproductive system cause long-term complications. Recent exploring source SARS-CoV-2 using genomic sequencing have revealed enters host cells via angiotensin-converting enzyme II (ACE2), receptor recognizes SARS-CoV. To investigate expression ACE2 to explore potential risk infection system,...
Abstract Purpose Flap endonuclease 1 (FEN1) is highly upregulated in prostate cancer and promotes the growth of cells. Androgen receptor (AR) most critical determinant occurrence, progression, metastasis, treatment cancer. However, effect FEN1 on docetaxel (DTX) sensitivity regulatory mechanisms AR expression need to be further studied. Methods Bioinformatics analyses were performed using data from Cancer Genome Atlas Gene Expression Omnibus. Prostate cell lines 22Rv1 LNCaP used. siRNA,...
Cyanidin is an anthocyanin found in many foods. Although its variable antioxidant levels are well-documented, little known about effects on renal cell carcinoma (RCC) tumorigenesis. This study, therefore, investigated the of cyanidin proliferation, migration, and invasion lines demonstrated, for first time, significant inhibitory RCC tumorigenesis.RCC cells were treated with different doses tested by Cell Counting Kit-8 reagent, clone formation assay, transwell flow cytometry. Moreover,...
The emergent need for new treatment methods multi-drug resistant pathogens such as methicillin-resistant Staphylococcus aureus (MRSA) has focused attention on novel potential tools like nanoparticles (NPs). In the present study, a drug-free cationic (CNPs) system was developed and its anti-MRSA effects were firstly investigated. results showed that CNPs (261.7 nm, 26.1 mv) time- concentration-dependent activity against MRSA growth, killing ∼ 90% of planktonic bacterial cells in 3 h at 400 μg...
Abstract Background The number of patients with diabetes is increasing worldwide. Diabetic testicular damage can cause spermiogenesis disorders and sexual dysfunction. We thus explored the role miRNAs in diabetic damage, revealed that they could serve as effective prevention treatment therapeutic targets. Methods Streptozotocin (STZ) was used to generate a rat model type 2 diabetes. Rat tissues were for miRNA mRNA sequencing. Through bioinformatics analysis, we constructed an miRNA–mRNA...
Background: N6-methyladenosine (m6A)–modified long noncoding RNAs (m6A-lncRNAs) have been proven to be involving in regulating tumorigenesis, invasion, and metastasis for a variety of tumors. The present study aimed screen lncRNAs with m6A modification investigate their biological signatures prognostic values kidney renal clear cell carcinoma (KIRC). Materials Methods: lncRNA-seq, miRNA-seq, mRNA-seq profiles KIRC samples the clinical characteristics corresponding patients were downloaded...
Background: The coronavirus disease of 2019 (COVID-19) is a severe public health issue that has infected millions people. effective prevention and control COVID-19 resulted in considerable increase the number cured cases. However, little research been done on complete metabonomic examination metabolic alterations patients following treatment. current project pursues rigorously to characterize variation serum metabolites between healthy controls with nucleic acid turning negative via...
This study aimed to establish a novel method for catalysing salidroside synthesis by immobilized β-D-glucosidase with deep eutectic solvents (DESs) as new green non-aqueous medium. To this end, the catalytic properties of (i.e. activity, stability, and enzymatic properties) were analysed within sixteen different DESs systems. Although most significantly improved enzyme they also reduced activity. was verified at molecular level employing fluorescence spectroscopy evaluate conformational...
Prostate cancer is the most common malignant urinary tumor among men. Treatments are currently unsatisfactory for advanced prostate cancer. Cancer biology remains basis developing new antitumor drugs. Therefore, it crucial to study metabolic reprogramming, immune microenvironment, and evasion of tumors. This aimed clarify relationship between glycolysis function in
Head and neck squamous cell carcinoma (HNSCC) is one of the most common cancers. Chemotherapy remains dominant therapeutic strategy, while a substantial proportion patients may develop chemotherapeutic resistance; therefore, it particularly significant to identify who could achieve maximum benefits from chemotherapy. Presently, four pyroptosis genes are reported correlate with response or prognosis HNSCC, no study has assessed combinatorial predicting efficacy these genes. Hence, this aims...
MicroRNAs (miRNAs) are post‑transcriptional regulators that mediate the initiation and progression of human cancer. Growing evidence suggests deregulation miRNA expression levels underlies chemo‑resistance. To investigate whether miRNA‑302a (miR‑302a) is involved in mediating chemo‑resistance to paclitaxel prostate cancer, a series vitro analyses were performed paclitaxel‑resistant cancer PC‑3PR cells non‑resistant PC‑3 cells. It was demonstrated miR‑302a upregulated Notably, ectopic also...
As an excellent grafting material, Malus baccata (L.) Borkh is native to Liaoning, Jilin, Heilongjiang and other regions in China, with a strong adverse environmental adaptability. typical transcription factor, the NAC gene acts as regulator many molecular pathways responding abiotic stress. However, research of has just begun. In present research, new MbNAC22, was obtained from seedlings baccata, its function drought salt treatments studied by heterologous expression. The open reading frame...
Partial bladder outlet obstruction (pBOO) often results in tissue inflammation and remodeling. As human urine-derived stem cells (USCs) have demonstrated therapeutic benefits, we used a rat model to investigate the effect of USCs on function explore miRNA gene expression profiles using RNA sequencing. Eighteen rats were assigned sham surgery group, pBOO pBOO+USC group (six biweekly treatments). Routine urodynamic monitoring, analysis detrusor muscle strips, pathophysiology assessments...
Introduction Thyroidectomy and thyrotropin suppressive therapy is the widely used surgical treatment for papillary thyroid carcinoma (PTC) patients. However, systematic metabolic changes of post-operative PTC patients were rarely reported. Methods Here, untargeted metabolomic detection cohorts from before (t0) 1-month-after (t1) thyroidectomy, performed to characterize circulating signatures after treatment. Results Our results showed exhibited lower stimulating hormone degree, higher total...
In recent years, genes associated with N6-methyladenosine (m6A) modification were found to participate in modulation of multiple tumor biological processes. Concomitantly, the significantly complicated dual effects microenvironment have been observed on cancer progression. The present study aims investigate m6A-related immune (m6AIGs) for their signatures and prognostic values bladder (BC). Out 2856 differentially expressed (DEGs) BC, a total 85 obtained following intersection DEGs, genes....
Abstract Objectives Bladder cancer (BLCA) is a tumor that affects men more than women. The biological function and prognostic value of androgen-responsive genes (ARGs) in BLCA are currently unknown. To address this, we established an androgen signature to determine the prognosis BLCA. Methods Sequencing data for from TCGA GEO datasets were used research. microenvironment (TME) was measured using Cibersort ssGSEA. Prognosis-related identified risk score model constructed univariate Cox...