A5076359457- Peptidase Inhibition and Analysis
- Neonatal Respiratory Health Research
- Ovarian cancer diagnosis and treatment
- Lung Cancer Research Studies
- Ethics and Legal Issues in Pediatric Healthcare
- Fibroblast Growth Factor Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastrointestinal Tumor Research and Treatment
- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
- Gastrointestinal disorders and treatments
- Neural Networks and Applications
- Spectroscopy Techniques in Biomedical and Chemical Research
- IL-33, ST2, and ILC Pathways
- Gastric Cancer Management and Outcomes
- Algal biology and biofuel production
- Machine Learning and Data Classification
- Nanoplatforms for cancer theranostics
- Signaling Pathways in Disease
- Optical Imaging and Spectroscopy Techniques
- RNA modifications and cancer
- Hippo pathway signaling and YAP/TAZ
- Lung Cancer Diagnosis and Treatment
- ATP Synthase and ATPases Research
- Machine Learning and Algorithms
The First Affiliated Hospital, Sun Yat-sen University
2024-2025
Zhongshan Hospital
2022-2025
Fudan University
2020-2025
Sun Yat-sen University
2024-2025
Nankai University
2022
Singapore University of Technology and Design
2021
Objective: This study aimed to explore the roles of serum tumor markers for metastasis and stage non-small cell lung cancer (NSCLC). Methods: recruited 3272 NSCLC patients admitted Tianjin Union Medical Center University Cancer Institute Hospital. The predictive abilities some (carcinoembryonic antigen (CEA), squamous carcinoma (SCC-Ag), cytokeratin-19 fragment (CYFRA 21-1), neuron-specific enolase (NSE), pro-gastrin-releasing peptide (ProGRP), total prostate-specific (TPSA) carbohydrate 199...
ABSTRACT Esophageal cancer is an aggressive malignancy with a poor prognosis. NUC7738, cordycepin derivative, has shown promise in overcoming the limited vivo efficacy of its parent compound. This study compares anticancer effects NUC7738 and esophageal explores molecular mechanisms action. In vitro, were tested on normal (Het1A) cell lines (ECA109, KYSE510) using Cell Counting Kit‐8 (CCK‐8) colony formation assays. Apoptosis was confirmed by inhibitors flow cytometry. Western blot performed...
Platinum resistance development is a dynamic process that occurs during continuous chemotherapy and contributes to high mortality in ovarian cancer. Abnormal glycosylation has been reported platinum resistance. Many studies on have performed, but few of them investigated resistance-associated glycans based N-glycomics. Moreover, glycomic alterations cancer are rarely reported. Therefore, the objective this study was determine resistance-related N-glycans cells exposure cisplatin. These might...
Abstract Background The defects and imbalance in lung repair structural maintenance contribute to the pathogenesis of chronic obstructive pulmonary diseases (COPD), yet molecular mechanisms that regulate process are so far incompletely understood. We hypothesized cigarette smoking causes glycocalyx impairment endothelial apoptosis COPD, which could be repaired by stimulation fibroblast growth factor 10 (FGF10)/FGF receptor 1 (FGFR1) signaling. Methods used immunostaining (immunohistochemical...
Abstract Background This study aimed to investigate whether patients with stage IB NSCLC could benefit from adjuvant chemotherapy. Methods In the years 2010 2015, 1,829 disease were chosen SEER database. To equalize baseline characteristics between surgery plus chemotherapy group (intervention) and alone (control), propensity score matching (PSM) was used. The log-rank test plotted Kaplan–Meier survival curves compare overall (OS) disease-specific (DSS). Cox proportional hazard regression...
The foundational assumption of machine learning is that the data under consideration separable into classes; while intuitively reasonable, separability constraints have proven remarkably difficult to formulate mathematically. We believe this problem rooted in mismatch between existing statistical techniques and commonly encountered data; object representations are typically high dimensional but tend treat dimensions a degenerate case. To address problem, we develop dedicated framework for...
Abstract Esophageal cancer is one of the most common malignant tumors, and 5-year overall survival rate only 20%. squamous cell carcinoma (ESCC) primary histological type esophageal in China. Protein phosphatase 1 regulatory subunit 18 (PPP1r18) actin-regulatory proteins able to bind protein catalytic alpha (PPP1CA). Yet, little known about role PPP1r18 ESCC. This study aimed elucidate biological functions ESCC progression. Clinical samples first confirmed that expression was upregulated...
Abstract Background Esophageal leiomyoma, also called Smooth Muscle Tumor (SMT), is one of the most common benign tumors esophagus. Surgical treatment widely used method, including thoracic surgery such as thoracotomy, and VATS, endoscopic ESD STER. We aimed to conduct a retrospective analysis all esophageal leiomyoma surgeries in our center assist decision-making minimally invasive for leiomyomas. Methods From January 2015 September 2023 patients with pathologically diagnosed at hospital...