A5028155058- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pulmonary Hypertension Research and Treatments
- Neonatal Respiratory Health Research
- Cancer-related molecular mechanisms research
- Pneumonia and Respiratory Infections
- Neuroscience of respiration and sleep
- Circular RNAs in diseases
- Respiratory Support and Mechanisms
- Reproductive System and Pregnancy
- Respiratory and Cough-Related Research
- Obstructive Sleep Apnea Research
- Pediatric health and respiratory diseases
- Heart Rate Variability and Autonomic Control
- COVID-19 Clinical Research Studies
- Asthma and respiratory diseases
- Endometrial and Cervical Cancer Treatments
- Long-Term Effects of COVID-19
- Nosocomial Infections in ICU
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Nanoplatforms for cancer theranostics
- SARS-CoV-2 and COVID-19 Research
- Chronic Disease Management Strategies
- Endometriosis Research and Treatment
- Inhalation and Respiratory Drug Delivery
- Tuberculosis Research and Epidemiology
Zhongshan Hospital
2018-2025
Shanghai Medical College of Fudan University
2018-2025
Fudan University
2018-2024
University of Science and Technology of China
2020-2024
Ruijin Hospital
2023
Shanghai Jiao Tong University
2023
The First Affiliated Hospital, Sun Yat-sen University
2016-2022
Sun Yat-sen University
2016-2022
Weatherford College
2021
ORCID
2020
Abstract Chronic obstructive pulmonary disease (COPD) is an intractable involving a sticky mucus layer and nanoagents with mucus‐penetrating capability offer new way to deliver drugs. However, drug release from nanovehicles requires optimization enhance the therapeutic effects of COPD therapy. Herein, black phosphorus quantum dots (BPQDs) are combined PEGylated chitosan nanospheres containing antibiotic amikacin (termed PEG@CS/BPQDs‐AM NPs). As drug‐delivery system, hydrophilicity PEG...
Endometriosis, affecting 6%–10% of women, often leads to pain and infertility its underlying inflammatory mechanisms are poorly understood. We established endometriosis models in wild-type IL16KO mice, revealing the driver function IL-16 initiating endometriosis-related inflammation. Using an vitro system, we confirmed iron overload-induced GSDME-mediated pyroptosis as a key trigger for activation release. In addition, our research led development Z30702029, compound inhibiting...
Background: Metagenomic Next Generation Sequencing (mNGS) has the potential to detect pathogens rapidly. We aimed assess diagnostic performance of mNGS in hospitalized patients with suspected sepsis and evaluate its role guiding antimicrobial therapy. Methods: A multicenter, prospective cohort study was performed. enrolled sepsis, collected clinical characteristics blood samples, recorded 30-day survival. Diagnostic efficacy test culture compared, impact on antibiotic regimen modification...
Immune checkpoint inhibitors (ICIs) therapy has revolutionized anti-cancer therapy, with lung cancer exhibiting sustained clinical responses to it. However, there remains a lack of research into the risk factors serious infections in patients following ICIs therapy. Therefore, we aimed investigate incidence and these patients. Medical records were retrospectively collected reviewed from 710 receiving at Zhongshan Hospital between January 2021 February 2023. Serious defined as requiring...
Background: COPD, characterized by chronic inflammation and airway remodeling, has significant pathological alterations in composition deposition of the extracellular matrix. The expression procollagen 1 C-terminal peptide (PICP) collagen type telopeptide (ICTP), two major by-products synthesis degradation collagen, was shown to be positively correlated with inflammatory mediator levels previous studies. Purpose: In this study, we investigated whether serum concentrations PICP ICTP were...
Abstract Background The defects and imbalance in lung repair structural maintenance contribute to the pathogenesis of chronic obstructive pulmonary diseases (COPD), yet molecular mechanisms that regulate process are so far incompletely understood. We hypothesized cigarette smoking causes glycocalyx impairment endothelial apoptosis COPD, which could be repaired by stimulation fibroblast growth factor 10 (FGF10)/FGF receptor 1 (FGFR1) signaling. Methods used immunostaining (immunohistochemical...
<b><i>Aims:</i></b> This study aimed to examine the clinical significance of carbohydrate antigen 125 (CA125) and human epididymis protein 4 (HE4) serum levels in combination for ovarian cancer detection patients. <b><i>Methods:</i></b> In total, 75 patients with cancer, 86 benign tumors, endometriosis 34 healthy women (as a control group) were selected from January 2012 July 2015 at Anhui province hospitals. The sensitivity specificity CA125,...
Background: In December of 2019, coronavirus disease 2019 (Covid-19) was reported in Wuhan, China, and has now rapidly swept around the world. Much research been carried out since outbreak, but few studies have focused on dysfunction adaptive immunity. Methods: this retrospective multi-center study, 373 patients with laboratory-confirmed COVID-19 from Shanghai Public Health Clinical Center Affiliated Hospital Putian University were recruited. Demographic, clinical, radiological features,...
The functions of DCST1-AS1 have been investigated in liver cancer, while its role endometrial carcinoma (EC) remains hardly known. This study aimed to analyze the EC.Paired EC and non-tumor tissue samples were obtained from 62 patients. These patients followed up for 5 years since their admission record survival conditions. HEC-1 cells transfected with DCST1-AS1, Notch1 vectors, miRNA negative control or miR-92a-3p mimic. Luciferase activity was measured. QPCR Western blot applied determine...
Purpose: By reanalyzing the gene expression profile GSE76925 in Gene Expression Omnibus database using bioinformatic methods, we attempted to identify novel candidate genes promoting development of emphysema patients with COPD. Patients and methods: According Quantitative CT data GSE76925, were divided into mild group (%LAA-950<20%, n=12) severe (%LAA-950.50%, n=11). Differentially expressed (DEGs) identified Agilent GeneSpring GX v11.5 (corrected P -value <0.05 |Fold Change|>1.3). Known...
Purpose: The co-existence of chronic obstructive pulmonary disease (COPD) and sleep apnea (OSA) has been described as the overlap syndrome. objective study is to investigate performance Berlin Questionnaire (BQ), modified (MBQ), STOP-Bang score in screening syndrome from COPD subjects how function interferes with questionnaire scoring. Subjects Methods: Among 116 included this study, 62 were 54 without OSA. asked fill out questionnaires collect demographic characteristics scores BQ, MBQ,...
// Weiping Hu 1,* , Guodong Niu Hongbo Li 1 Hanyuan Gao Rudian Kang Xiaoqing Chen and Ling Lin Rheumatism Department, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Province, China * These authors have contributed equally to this study Correspondence to: Chen, email: Lin, Keywords : IFIT1, podocytes, animal study, renal pathological changes, lupus nephritis, Immunology Microbiology Section, Immune response, Immunity Received July 28, 2016 Accepted October Published...
Background Obesity and chronic obstructive pulmonary disease (COPD) are prevailing worldwide, bringing a heavy medical burden. Clinical pathophysiological relationship between obesity COPD is paradoxical elusive. We aim to explore their inherent associations from clinical, genetic, animal levels. Methods performed literature review cohort analysis of patients with compare lung function, symptom, prognosis among different weight groups. After retrieving datasets in Gene Expression Omnibus...
Acute exacerbation (AE) is the main cause of increased disability and mortality for patients with Chronic Obstructive Pulmonary Disease (COPD). Short-term re-exacerbation after discharge common in-hospital AECOPD. Thus, we aimed to design a scoring system effectively predict 30-day using simple easily accessible variables. We retrospectively enrolled 686 cases hospitalized AECOPD in two Chinese hospitals from 2005 2017. A variety parameters were collected like demographics, clinical...
Abstract Chronic obstructive pulmonary disease (COPD) is an intractable involving a sticky mucus layer and nanoagents with mucus‐penetrating capability offer new way to deliver drugs. However, drug release from nanovehicles requires optimization enhance the therapeutic effects of COPD therapy. Herein, black phosphorus quantum dots (BPQDs) are combined PEGylated chitosan nanospheres containing antibiotic amikacin (termed PEG@CS/BPQDs‐AM NPs). As drug‐delivery system, hydrophilicity PEG...
Background: Patients with chronic obstructive pulmonary disease (COPD) are more susceptible to Aspergillus colonization or infection. Several studies have demonstrated that invasive Aspergillosis (IPA) and hypersensitivity (AH) a detrimental effect on COPD. However, it remains be clarified whether is associated acute exacerbation of COPD (AECOPD). This study aimed explore the impact in lower respiratory tract AECOPD. Method: were identified from retrospective cohort hospitalized AECOPD 2011...
Despite the release of a national guideline in 2016, actual practices with respect to adult community-acquired pneumonia (CAP) remain unknown China. We aimed investigate CAP patient management Shanghai identify potential problems and provide evidence for policy making.A short-period, 5-day prospective cross-sectional study was performed sampled pulmonologists from 36 hospitals, encompassing all administrative districts Shanghai, during January 8-12, 2018. The medical information recorded...
Background: Idiopathic pulmonary arterial hypertension (IPAH) is a life-threatening disease. Owing to its high fatality rate and narrow therapeutic options, identification of the pathogenic mechanisms IPAH becoming increasingly important. Methods: In our research, we utilized robust rank aggregation (RRA) method integrate four eligible (PAH) microarray datasets identified significant differentially expressed genes (DEGs) between normal samples. Gene Ontology (GO) Kyoto Encyclopedia Genes...