A5100617357- Chronic Obstructive Pulmonary Disease (COPD) Research
- Antimicrobial Resistance in Staphylococcus
- Bacterial Identification and Susceptibility Testing
- Pulmonary Hypertension Research and Treatments
- Traditional Chinese Medicine Studies
- Heart Rate Variability and Autonomic Control
- Phytoestrogen effects and research
- Pneumonia and Respiratory Infections
- Obstructive Sleep Apnea Research
- Respiratory Support and Mechanisms
- Healthcare and Venom Research
- Body Composition Measurement Techniques
- Antifungal resistance and susceptibility
- Clostridium difficile and Clostridium perfringens research
- Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Medical Research and Treatments
- Respiratory and Cough-Related Research
- Forensic Anthropology and Bioarchaeology Studies
- Cardiovascular Conditions and Treatments
- Transplantation: Methods and Outcomes
- Safe Handling of Antineoplastic Drugs
- Traditional Chinese Medicine Analysis
- Nosocomial Infections in ICU
- Preterm Birth and Chorioamnionitis
Tianjin First Center Hospital
2018-2025
Tianjin Medical University
2018-2025
Nankai University
2025
Central Hospital of Putuo District
2020-2024
Hebei Medical University
2024
Xingtai People's Hospital
2024
Ministry of Agriculture and Rural Affairs
2023
Weifang Chinese Medicine Hospital
2005-2021
Sichuan University
2021
Harbin Medical University
2017-2019
Vancomycin is a first-line antibiotic used for the treatment of severe gram-positive bacterial infections. Clinical guidelines recommend that vancomycin trough concentration be 10-15 mg/L regular infections and 15-20 We investigated whether increasing would result in better clinical outcomes with sustainable adverse effects (AEs) Chinese population.A prospective, open, multicenter observational study was performed patients from 13 teaching hospitals. Patients received therapeutic drug...
Abstract Incarvillea sinensis is a Bignoniaceae plant used to treat rheumatism and relieve pain in traditional Chinese medicine. As major component of I. , incarvillateine has shown analgesic activity mice formalin tests. Using series animal models, this study further evaluated the effects against acute, inflammatory neuropathic pain. Incarvillateine (10 or 20 mg/kg, i.p.) dose-dependently attenuated acetic acid-induced writhing, but did not affect thermal threshold hot plate test. In...
Background: Chronic obstructive pulmonary disease (COPD) is characterized by and systemic inflammatory processes, exacerbation of COPD represents a critical moment in the progression COPD. Several biomarkers inflammation have been proposed to predictive function acute exacerbation. However, their use still limited routine clinical practice. The purpose our study explore prognostic efficacy novel hemogram indexes among stable patients. Method: A total 275 patients from Shanghai Investigation...
This study aimed to identify the potential factors associated with immune thyroid dysfunction caused by programmed death 1 (PD-1)/programmed ligand (PD-L1) inhibitors in cancer patients. We conducted a retrospective of immune-related adverse events (irAEs) patients treated PD-1/PD-L1 at Tianjin First Central Hospital from January 2020 March 2023. Thyroid irAEs were characterized as hypothyroidism, hyperthyroidism and thyrotoxicosis followed hypothyroidism. A total 175 screened study, whom 48...
The mud crab, Scylla paramamosain, has abundant nutrients in the ovary, where numerous lipids accumulate during ovarian maturation. However, mechanism behind accumulation of ovary crab maturation is largely unknown. This study conducted a comparative transcriptome analysis ovaries crabs at various stages A total 63.69 Gb clean data was obtained, with Q30 93.34%, and 81,893 unigenes were identified, including 10,996 differentially expressed genes (DEGs). After KEGG enrichment these DEGs, MAPK...
Astragaloside (AGS) extracted from radix astragalin (Huangqi) has been considered to be beneficial liver diseases. In this study, we examined the role played by AGS in alleviating hepatic fibrosis function via protease-activated receptor-2 (PAR2) mechanisms. We hypothesized that affects PAR2 signaling pathway thereby improving rats with induced carbon tetrachloride (CCl4). further attenuates impaired evoked CCl4 a greater degree diabetic animals.ELISA and Western Blot analysis were used...
Dysfunction and injury of endothelial cells play critical roles in pulmonary arterial hypertension, including aberrant proliferation, suppressed apoptosis, excessive angiogenesis. The 12-lipoxygenase 12-hydroxyeicosatetraenoic acid pathway, which has been considered as a crucial mediator, elevates vascular resistance pressure. However, the mechanisms underlying bioactivity vasculature, especially cells, are still elusive. Thus we aim to determine key role...
Our aims in this prospective study were to evaluate the correlations between pharmacokinetic/pharmacodynamic (PK/PD) indices and clinical/microbiological efficacy of vancomycin identify an appropriate PK/PD target Chinese population guide treatment clinic.Adult patients from 11 hospitals China with gram-positive infections who received therapy for ≥5 days under therapeutic drug monitoring (TDM) enrolled study. A 1-compartment PK model was established validated. The (Cmin, Cmax, 0-24 hour...
This study aimed to examine the risk factors of augmented renal clearance (ARC) and association between ARC vancomycin pharmacokinetic/pharmacodynamic (PK/PD) indices in Chinese adult patients. A prospective, observational, multicenter was conducted, 414 patients undergoing therapeutic drug monitoring (TDM) were enrolled. Clinical PK/PD data compared non-ARC groups. Independent examined using a multivariate logistic regression analysis. The trauma intensive care (ARCTIC) scoring systems...
Novel roughness-controlled mannitol/LB Agar microparticles were synthesized by polymorphic transformation and self-assembly method using hexane as the reagent spray-dried starting material. As-prepared characterized Fourier transform infrared spectra (FTIR), X-ray diffraction (XRD), differential scanning calorimetry (DSC), electron microscopy (SEM), thermal gravimetric analysis (TGA), Andersen Cascade Impactor (ACI). The XRD DSC results indicate that after immersing in hexane, β-mannitol was...
Despite the release of a national guideline in 2016, actual practices with respect to adult community-acquired pneumonia (CAP) remain unknown China. We aimed investigate CAP patient management Shanghai identify potential problems and provide evidence for policy making.A short-period, 5-day prospective cross-sectional study was performed sampled pulmonologists from 36 hospitals, encompassing all administrative districts Shanghai, during January 8-12, 2018. The medical information recorded...
Background: Patients with chronic obstructive pulmonary disease (COPD) are more susceptible to Aspergillus colonization or infection. Several studies have demonstrated that invasive Aspergillosis (IPA) and hypersensitivity (AH) a detrimental effect on COPD. However, it remains be clarified whether is associated acute exacerbation of COPD (AECOPD). This study aimed explore the impact in lower respiratory tract AECOPD. Method: were identified from retrospective cohort hospitalized AECOPD 2011...
Objective: To explore impact of Candida on the acute exacerbation chronic obstructive pulmonary disease (AECOPD) outcome. Methods: A retrospective, multi-center, case-control study was performed. Patients hospitalized for AECOPD in 25 centers during Jan 2011 – Dec 2016 were enrolled, data including demographic information, conditions stable phase COPD, clinical characteristics and follow-up information within 1 year after discharge collected. Univariate analysis binary logistic regression...
Objective. To explore the influencing factors of daytime sleepiness in patients with obstructive sleep apnea hypopnea syndrome (OSAHS) and correlation between pulse oxygen decline rate severe OSAHS. Methods. From January 2018 to April 2021, 246 consecutive OSAHS diagnosed by polysomnography (PSG) our hospital were selected. All grouped according minimum nocturnal saturation index (AHI). There 33 cases no hypoxia group, 34 mild 119 moderate 60 group. 30 simple snoring 55 48 113 The Epworth...
Vancomycin remains the mainstay of treatment for methicillin-resistant Staphylococcus aureus (MRSA) pneumonia. This study assessed risk factors vancomycin failure in 63 patients with MRSA pneumonia through detailed clinical, microbiological, pharmacokinetic/pharmacodynamic, and genetic analyses prospective multicenter studies conducted from February 2012 to July 2018. Therapeutic drug monitoring was performed during treatment, 24-h area under curve (AUC0-24) calculated. All baseline strains...
Puerarin injection is commonly used in clinical treatment of coronary heart disease, angina pectoris, retinal artery, vein occlusion, sudden deafness and so on. This paper aimed to evaluate the safety puerarin use explore related factors that may cause its adverse reactions (ADRs), as find warning signal medication time, put forward early warning, make judgment treatment, ensure drug use. By strengthening surveillance, best plan was established prevent occurrence enhance people's awareness...
It has been noted that there is an increase in the incidence of acute cardiovascular events (CVEs) patients with chronic obstructive pulmonary disease (COPD) during exacerbation (AE), thereby causing increased inpatient mortality. Thus, we have tried to identify predictors CVEs AECOPD via a nested case-control study.A total 496 cases hospitalized for were included this study, and followed-up up 6 months after discharge. Acute AE period defined as new or worsening coronary syndrome (ACS),...
The aim of our study was to examine the association Angiomotin (Amot-p130) and Yes-associated protein 1 (YAP1) expressions their prognostic significance in epithelial ovarian cancer (EOC).