A5008371412- COVID-19 epidemiological studies
- Influenza Virus Research Studies
- HIV/AIDS Research and Interventions
- Viral Infections and Outbreaks Research
- Mathematical and Theoretical Epidemiology and Ecology Models
- Antibiotic Use and Resistance
- Adolescent Sexual and Reproductive Health
- Patient Satisfaction in Healthcare
- Respiratory viral infections research
- HIV/AIDS drug development and treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Malaria Research and Control
- Immune Cell Function and Interaction
- Sex work and related issues
- Global Maternal and Child Health
- Evolution and Genetic Dynamics
- Data-Driven Disease Surveillance
- Zoonotic diseases and public health
- Pharmaceutical Practices and Patient Outcomes
- Yersinia bacterium, plague, ectoparasites research
- Sexuality, Behavior, and Technology
- SARS-CoV-2 and COVID-19 Research
- HIV Research and Treatment
- HIV, Drug Use, Sexual Risk
Heidelberg University
2023-2024
University Hospital Heidelberg
2024
British Columbia Children's Hospital
2024
Imperial College London
2020-2023
Pennsylvania State University
2023
Abbott Northwestern Hospital
2021-2022
Hanoi Medical University
2022
Hershey (United States)
2022
St Mary's Hospital
2022
Hospital for Tropical Diseases
2012-2021
The recent outbreaks of Ebola virus (EBOV) infections have underlined the impact as a major threat for human health. Due to high biosafety classification EBOV (level 4), basic research is very limited. Therefore, development new avenues thinking advance quantitative comprehension and its interaction with host cells urgently needed tackle this lethal disease. Mathematical modeling dynamics can be instrumental interpret infection kinetics on grounds. To best our knowledge, mathematical...
Mathematical modelling approaches have granted a significant contribution to life sciences and beyond understand experimental results. However, incomplete inadequate assessments in parameter estimation practices hamper the reliability, consequently insights that ultimately could arise from mathematical model. To keep diligent works biological systems being mistrusted, potential sources of error must be acknowledged. Employing popular model viral infection research, existing means are...
Abstract Objective To analyse data from 2016–17 a hospital-based antimicrobial resistance surveillance with national coverage in network of hospitals Viet Nam. Methods We analysed 13 hospitals, 3 less than the dataset 2012–13 period. Identification and susceptibility testing clinical microbiology laboratories samples sent for routine diagnostics were used. Clinical Laboratory Standards Institute 2018 guidelines used interpretation. WHONET was entry, management analysis. Results 42,553...
From August to November 2017, Madagascar endured an outbreak of plague. A total 2417 cases plague were confirmed, causing a death toll 209. Public health intervention efforts introduced and successfully stopped the epidemic at end November. The plague, however, is endemic in region occurs annually, posing risk future outbreaks. To understand transmission, we collected real-time data from official reports, described outbreak's characteristics, estimated transmission parameters using...
In the course of influenza A virus (IAV) infections, a secondary bacterial infection frequently leads to serious respiratory conditions provoking high hospitalization and death tolls. Although abundant pro-inflammatory responses have been reported as key contributing factors for these severe dual relative contributions cytokines remain largely unclear. current study, mathematical modelling based on murine experimental data dissects IFN-γ cytokine candidate responsible impaired clearance,...
To establish a hospital-based surveillance network with national coverage for antimicrobial resistance (AMR) and antibiotic consumption in Viet Nam.A 16-hospital (Viet Nam Resistance: VINARES) was established consisted of provincial-level hospitals across the country. Antimicrobial susceptibility testing results from routine clinical diagnostic specimens data Defined Daily Dose per 1000 bed days (DDD/1000 patient-days) were prospectively collected analysed between October 2012 September...
This study examined characteristics of HIV-infected patients in the TREAT Asia HIV Observational Database who were lost to follow-up (LTFU) from treatment and care. Time last clinic visit 31 March 2009 was analysed determine interval that best classified LTFU. Patients defined as LTFU then categorised into permanently (never returned) temporary (re-entered later), these groups compared. A total 3626 included (71% male). No visits for 180 days best-performing definition (sensitivity 90.6%,...
Abstract Ebola virus (EBOV) infection causes a high death toll, killing proportion of EBOV-infected patients within 7 days. Comprehensive data on EBOV are fragmented, hampering efforts in developing therapeutics and vaccines against EBOV. Under this circumstance, mathematical models become valuable resources to explore potential controlling strategies. In paper, we employed experimental nonhuman primates (NHPs) construct framework for determining windows opportunity treatment vaccination....
Abstract Background Debuting sexual intercourse marks exposure to pregnancy or fatherhood and sexually transmitted infections (STIs), including HIV. In sub-Saharan Africa (SSA), debut varies according cultural, religious, economic factors, encouraging delay has been a longstanding component of behavioural HIV prevention strategies. Age at first sex (AFS) is routinely collected in national household surveys, but data are affected by reporting biases, limiting utility monitor trends guide...
Background Innovative mobile health (mHealth) interventions can improve maternal knowledge, thereby supporting national efforts to reduce preventable and child mortality in South Africa. Studies have documented a potential role for video content support perinatal messaging, enhance satisfaction, overcome literacy barriers. Short, animated storytelling (SAS) is an innovative, emerging approach mHealth messaging. Objective We aimed measure the effect of SAS videos on knowledge user...
Antiretroviral therapy (ART) retention and 5 early-warning indicators (EWIs) of HIV drug resistance (HIVDR) were abstracted at 27 adult 4 pediatric clinics in Vietnam 2009. Of 4531 adults 313 children, 81.2% 84.4% respectively still on ART 12 months. More than 90% the monitored achieved World Health Organization (WHO) targets for lost-to-follow-up (LTFU), prescribing practices, ARV supply continuity. Only 83.9% met target first-line 79.3% clinic appointment-keeping. Clinic factors (i.e....
Abstract Background and Aim Although treatment with direct‐acting antivirals has dramatically improved morbidity mortality attributable to chronic hepatitis C virus infection, universal access these medicines been slow in the Asia–Pacific region Russia. This study evaluated efficacy safety of elbasvir/grazoprevir participants infection from countries Russia (C‐CORAL). Methods C‐CORAL was a phase 3, randomized, placebo‐controlled (NCT02251990). Treatment‐naive, HIV‐negative, cirrhotic...
Recent epidemics have entailed global discussions on revamping epidemic control and prevention approaches. A general consensus is that all sources of data should be embraced to improve preparedness. As a disease transmission inherently governed by individual-level responses, pathogen dynamics within infected hosts posit high potentials inform population-level phenomena. We propose multiscale approach showing individual were able reproduce observations. Using experimental data, we formulated...
Stockpiling neuraminidase inhibitors (NAIs) such as oseltamivir and zanamivir is part of a global effort to be prepared for an influenza pandemic. However, the contribution NAIs treatment prevention its complications largely debatable due constraints in ability control confounders explore unobserved areas drug effects. For this study, we used mathematical model infection which allowed transparent analyses. The recreated effects indicated that: (i) efficacy was limited by design, (ii) 99%...
The evolution of influenza viruses is fundamentally shaped by within-host processes. However, the evolutionary dynamics remain incompletely understood, in part because most studies have focused on infections healthy adults based single timepoint data. Here, we analyzed 82 longitudinally sampled individuals, mostly young children, infected with A/H1N1pdm09 or A/H3N2 between 2007 and 2009. For during 2009 pandemic, nonsynonymous minority variants were more prevalent than synonymous ones. early...
Annual influenza epidemics significantly burden health care. Anticipating them allows for timely preparation. The Scientific Institute of Public Health in Belgium (WIV-ISP) monitors the incidence and influenza-like illnesses (ILIs) reports on a weekly basis. General practitioners working out-of-hour cooperatives (OOH GPCs) register diagnoses ILIs an instantly accessible electronic record (EHR) system. This article has two objectives: to explore possibility modelling seasonal using EHR ILI...
Leptospirosis is the most common zoonotic disease worldwide. The diagnostic performance of a serological test for human leptospirosis mainly influenced by antigen used in assay. An ideal should cover all serovars pathogenic leptospires with high sensitivity and specificity use reagents that are relatively inexpensive to produce can be tropical climates. Peptide-based tests fulfil at least latter two requirements, ORFeome phage display has been successfully identify immunogenic peptides from...
The Global AIDS Strategy 2021-2026 identifies adolescent girls and young women (AGYW) as a priority population for HIV prevention, recommends differentiating intervention portfolios geographically based on local incidence individual risk behaviours. We estimated prevalence of behaviours associated at health district level among AGYW living in 13 countries sub-Saharan Africa. analysed 46 geospatially-referenced national household surveys conducted between 1999-2018 across high burden Female...
<sec> <title>BACKGROUND</title> Stigma towards transgender children and adolescents contributes to significantly reduced health educational outcomes compared non-transgender individuals. Contact with a member of stigmatized community can dismantle stereotypes reduce stigma. Recent evidence suggests that video-based contact interventions be as effective face-to-face encounters. By allowing the audience experience cognitive emotional perspectives their protagonists, entertainment narratives...
Background Stigma toward transgender children and adolescents negatively impacts their health educational outcomes. Contact with members of stigmatized groups can dismantle stereotypes reduce stigma by facilitating exposure to the unique cognitive emotional perspectives individuals within group. Recent evidence suggests that video-based contact interventions be as effective face-to-face encounters, but challenges lie in protecting identities youth, since many them live stealth. Objective...
Abstract With more than 60 million confirmed cases and 1.5 deaths, SARS-CoV-2 has paralyzed our societies, leading to self isolation quarantine for several months. A COVID-19 vaccine remains a critical element in the eventual solution this public health crisis. Two vaccines are ready be mass produced eventually supplied population. Here, we develop an epidemiological network model able represent pandemic dynamics of different countries such as Italy. Stochastic computational simulations...
Nowadays, infections by viral pathogens are one of the biggest health threats to mankind. The development new avenues thinking integrate complexity infectious diseases and immune system is urgently needed. Recently mathematical modelling has emerged as a tool interpret experimental results on quantitative grounds providing relevant insights understand several diseases. Nevertheless, complex mechanisms between viruses can result in models with large number parameters be estimated....