A5100786331- Computational Drug Discovery Methods
- Traditional Chinese Medicine Analysis
- Plant-based Medicinal Research
- Pharmacological Effects of Natural Compounds
- Natural product bioactivities and synthesis
- Crystallization and Solubility Studies
- Curcumin's Biomedical Applications
- Drug Solubulity and Delivery Systems
- Pharmacological Receptor Mechanisms and Effects
- Artificial Intelligence in Healthcare
- Medicinal Plants and Bioactive Compounds
- Innovative Microfluidic and Catalytic Techniques Innovation
- Plant biochemistry and biosynthesis
- Genomics, phytochemicals, and oxidative stress
- Synthesis and biological activity
- Geological and Geophysical Studies
- Inflammatory mediators and NSAID effects
- Machine Learning in Healthcare
- Ginseng Biological Effects and Applications
- Biomedical Text Mining and Ontologies
- Geological formations and processes
- Antioxidant Activity and Oxidative Stress
- Bioinformatics and Genomic Networks
- Microencapsulation and Drying Processes
- Traditional Chinese Medicine Studies
Chengdu University of Traditional Chinese Medicine
2017-2023
Applied Radar (United States)
2022
Waterborne Environmental (United States)
2022
Beijing University of Chinese Medicine
2014-2016
The traditional Chinese Medicine (TCM) herbal formula Lian Hua Qing Wen (LHQW) improves the results of COVID-19 treatment. Three very recent studies analyzed with network pharmacology some working mechanisms LHQW. However, we used more techniques and also included Angiotensin converting enzyme 2 (ACE2) (a SARS-CoV receptor, possibly viral entry point in alveolar lung cells) immune system, as cytokine storm is essential late phase. Extensive detailed Network Pharmacology analysis LHQW-...
As a subclass of the biopharmaceutical classification system (BCS) class II, basic drugs (BCS IIB) exhibit pH-dependent solubility and tend to generate supersaturation in gastrointestinal tract, leading less qualified vitro-in vivo correlation (IVIVC). This study aims develop physiologically based multi-cup dissolution approach improve evaluation for higher quality IVIVC preliminarily explores molecular mechanism precipitation ketoconazole affected by Polyvinylpyrrolidone-vinyl acetate...
Curcumin, the medically active component from Curcuma longa (Turmeric), is widely used to treat inflammatory diseases. Protein interaction network (PIN) analysis was predict its mechanisms of molecular action. Targets curcumin were obtained based on ChEMBL and STITCH databases. Protein–protein interactions (PPIs) extracted String database. The PIN constructed by Cytoscape function modules identified gene ontology (GO) enrichment complex detection (MCODE). A with 482 nodes 1688 constructed,...
Tanshinone IIA (Tan IIA) is one of the major fat-soluble ingredients in Salvia miltiorrhiza which has been widely used for various inflammatory conditions associated with cardiovascular and cerebrovascular disorders. However, underlying anti-infl
According to Traditional Chinese Medicine (TCM), Aconiti Radix Cocta (AC) is clinically employed expel wind, remove dampness, and relieve pain. We evaluated the antirheumatoid arthritis (RA) activities underlying mechanisms of AC. The chemical constituents AC were analyzed by high-performance liquid chromatography (HPLC) using three reference compounds (benzoylaconitine, benzoylmesaconine, benzoylhypacoitine). anti-RA effects in adjuvant-induced (AIA) rats hind paw volume histopathological...
Abstract Background Most lung cancer patients worldwide (stage IV non-small cell cancer, NSCLC) have a poor survival: 25%-30% die < 3 months. Yet, of those surviving > months, 10%-15% survive (very) long. Astragali radix (AR) is an effective traditional Chinese medicine widely used for (NSCLC). However, the pharmacological mechanisms AR on NSCLC remain to be elucidated. Methods Ultra Performance Liquid Chromatography system coupled with Q-Orbitrap HRMS (UPLC-Q-Orbitrap HRMS) was...
Background . The Coronavirus Disease 2019 (COVID‐19) outbreak in Wuhan, China, was caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). Anisodamine hydrobromide injection (AHI), the main ingredient of which is anisodamine, a listed drug for improving microcirculation China. can improve condition patients with COVID‐19. Materials and Methods Protein‐protein interactions obtained from String databases were used to construct protein interaction network (PIN) AHI using...
Qishen Yiqi formula (QSYQ) has the effect of tonifying Qi and promoting blood circulation, which is widely used to treat cardiovascular diseases with deficiency stasis syndrome. However, mechanism QSYQ tonify promote circulation rarely reported at molecular or systems level. This study aimed elucidate based on protein interaction network (PIN) analysis. The targets’ information active components was obtained from ChEMBL STITCH databases further search against protein-protein interactions by...
Inflammation is one of the important risk factors rheumatic diseases. Aconiti Radix widely used for treatment rheumatism, which has significant anti-inflammatory effects. However, its mechanism on molecular level still not clear. The purpose this study to illuminate based protein interaction network (PIN) analysis level. main components (aconitine, hypaconitine and mesaconitine) were chosen in obtain targets protein-protein information though databases retrieval construct PIN Radix. By a...
Abstract This study explores the application of single-channel seismic (SCS) method for offshore wind farm site assessments in China’s Beibu Gulf region, addressing limitations traditional drilling through an innovative data processing workflow. Given increasing global demand renewable energy and leadership capacity, there’s a significant push towards exploiting Gulf’s resources. However, area’s complex geological challenges, such as thick sand layers stratification differences, necessitate...
Cryptotanshinone (CPT) is one of the major liposoluble ingredients in Salvia miltiorrhiza which exerts antitumor activity on several types cancers. However, action mechanism CPT remained to be clarified. The current study aimed elucidate based protein interaction network (PIN) analysis. A PIN was constructed with 244 nodes and 778 interactions, analyzed by Gene ontology (GO) enrichment analysis Markov Cluster algorithm (MCL). Two modules were found intimately associated antitumor. Still...
Used extensively to treat cardiovascular disease, Danqi analogous formulas (DQAF) include prescriptions for (DQ), Fufang Danshen (FFDS) and Qishen Yiqi (QSYQ). Differences in prescription compatibility result varying emphases of DQAF clinical application. Based on network analysis this study, common distinct mechanisms actions disease were analyzed at a systemic level. Components–targets–pathways models developed by Cytoscape (http://www.cytoscape.org/); whereby, target information active...
Objective: Angina pectoris (AP), affecting over 523 million people, can be alleviated by corydalis rhizome (CR), usually combined with chuanxiong (CXR), angelica dahuricae radix (ADR), or astragali (AR) to enhance the effect. This study aims distinguish different mechanisms among 3 drug pairs treat AP. Methods: The pair-disease intersection targets, compound protein–protein interaction (PPI), and herb-compound-target-pathway network were obtained Cytoscape, STRING, Gene Ontology (GO), Kyoto...
"Qi medicinal herbs" in China refers to a kind of regional national folk herbs related the treatment five labors and seven injuries,the last word which is "Qi". Our study sort out standardize name basic confused varieties through establishment " Qi VFP information database. variety sorting model literature research-variety survey-data mining-spatial distribution" was developed by means analysis names were summarized sorted out. The relationship between distribution resources use ethnic...