Jia Zhang

ORCID: 0000-0001-8982-6666
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About
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Research Areas
  • Mobile Health and mHealth Applications
  • Tea Polyphenols and Effects
  • Atherosclerosis and Cardiovascular Diseases
  • Dermatologic Treatments and Research
  • Pressure Ulcer Prevention and Management
  • Respiratory Support and Mechanisms
  • Neonatal Respiratory Health Research
  • Diabetic Foot Ulcer Assessment and Management
  • Chronic Obstructive Pulmonary Disease (COPD) Research
  • Wound Healing and Treatments
  • Diagnosis and Treatment of Venous Diseases
  • Context-Aware Activity Recognition Systems
  • Systemic Sclerosis and Related Diseases
  • Healthcare Systems and Reforms
  • Nuclear Physics and Applications
  • Diabetes Management and Education
  • Cholesterol and Lipid Metabolism
  • Brain Tumor Detection and Classification
  • Applied Advanced Technologies
  • Pneumothorax, Barotrauma, Emphysema
  • E-commerce and Technology Innovations
  • ECG Monitoring and Analysis
  • Cerebral Venous Sinus Thrombosis
  • Inflammatory Biomarkers in Disease Prognosis
  • Global Maternal and Child Health

United Imaging Healthcare (China)
2024

Changchun University of Chinese Medicine
2024

First Affiliated Hospital of Xi'an Jiaotong University
2024

Chongqing University of Education
2023

Sun Yat-sen University
2023

Sun Yat-sen Memorial Hospital
2023

Weatherford College
2022

ETH Zurich
2017-2022

Henan University
2021

Huazhong University of Science and Technology
2020

Chronic wounds significantly impact quality of life. They can rapidly deteriorate and require close monitoring healing progress. Image-based wound analysis is a way objectively assessing the status by quantifying important features that are related to healing. However, high heterogeneity types imaging conditions challenge robust segmentation images. We present Detect-and-Segment (DS), deep learning approach produce maps with generalization capabilities. In our approach, dedicated neural...

10.1016/j.imu.2022.100884 article EN cc-by-nc-nd Informatics in Medicine Unlocked 2022-01-01

With tens of thousands electrocardiogram (ECG) records processed by mobile cardiac event recorders every day, heart rhythm classification algorithms are an important tool for the continuous monitoring patients at risk.We utilise annotated dataset 12,186 single-lead ECG recordings to build a diverse ensemble recurrent neural networks (RNNs) that is able distinguish between normal sinus rhythms, atrial fibrillation, other types arrhythmia and signals too noisy interpret.In order ease learning...

10.22489/cinc.2017.363-223 article EN Computing in cardiology 2017-09-14

We have successfully synthesized (-)-epigallocatechin-3-gallate (EGCG) encapsulated nanostructured lipid carriers (NLCE) and chitosan-coated NLCE (CSNLCE) using natural lipids, surfactant, chitosan, EGCG. Nanoencapsulation dramatically improved EGCG stability. CSNLCE significantly increased content in THP-1-derived macrophages compared with nonencapsulated As to 10 μM EGCG, both at the same concentration decreased macrophage cholesteryl ester content. mRNA levels protein secretion of...

10.1021/jf4023004 article EN Journal of Agricultural and Food Chemistry 2013-08-26

Children with focal hyperinsulinism of infancy display a dramatic, non-neoplastic clonal expansion β cells that have undergone mitotic recombination, resulting in paternal disomy part chromosome 11. This disomic region contains imprinted genes, including the gene encoding cell cycle inhibitor p57Kip2 (CDKN1C), which is silenced as consequence recombination event. We hypothesized targeting could stimulate adult human replication. Indeed, when we suppressed CDKN1C expression islets obtained...

10.1172/jci69519 article EN Journal of Clinical Investigation 2014-01-15

Abstract Acute pancreatitis (AP) continues to pose a major challenge as targeted therapeutic interventions are absent. Mitochondrial dysfunction and inflammasome-dependent pyroptosis involved in the pathogenic mechanisms of AP. CIRP is stress-response protein damage-associated molecular pattern (DAMP) molecule. In our previous studies, we discovered that excessive can directly damage pancreatic acinar cells. Nonetheless, precise involvement AP still unexplored. The primary aim this study was...

10.1038/s41420-024-01923-6 article EN cc-by Cell Death Discovery 2024-03-27

Background Travel to clinics for chronic wound management is burdensome patients. Remote assessment and of wounds using mobile telehealth approaches can reduce this burden improve patient outcomes. An essential step in documentation the capture images, but poor image quality have a negative influence on reliability assessment. To date, no study has investigated remotely acquired images whether these are suitable self-management telemedical interpretation status. Objective Our goal was...

10.2196/26149 article EN cc-by JMIR mhealth and uhealth 2021-07-30

This study explores the relationship between self-efficacy, sports participation, and health promotion behavior for middle-aged elderly people. Therefore, it provides a theoretical reference improving quality of life adults promoting healthy lifestyle elderly.A total 591 (men: 36.2%; women: 63.8%; age: above 50 years) from five cities Henan Province were selected as research objects by convenient sampling. The scales used questionnaire survey. Amos24.0 was to test structural equation model,...

10.3389/fpsyg.2022.889063 article EN cc-by Frontiers in Psychology 2023-01-04

Hrd1 has recently emerged as a critical regulator of B-cells in autoimmune diseases. However, its role the pathogenesis chronic rhinosinusitis with nasal polyps (CRSwNP) remains largely unexplored. This study aimed to examine expression and B-cell accumulation their possible roles CRSwNP.Quantitative real-time polymerase chain reaction, immunohistochemistry, enzyme-linked immunosorbent assay Western blotting were used assess gene protein tissue extracts. Cells isolated from tissues...

10.4168/aair.2018.10.6.698 article EN Allergy Asthma and Immunology Research 2018-01-01

Measuring peripheral oxygen saturation (SpO2) with pulse oximeters at the point of care is widely established. However, since SpO2 dependent on ambient atmospheric pressure, distribution values in populations living above 2000 m a.s.l. largely unknown. Here, we propose and evaluate a computer model to predict for pediatric permanent residents between 0 4,000 Based sensitivity analysis transport parameters, created an altitude-adaptive that takes physiological adaptation into account. From...

10.1152/japplphysiol.00478.2018 article EN Journal of Applied Physiology 2019-08-08

The fungus strain DZ-3 was isolated from twigs of the well-known medicinal plant Eucommia ulmoides Oliver and identified as Aspergillus flavipes. Two new alkaloids, named asperflaloids A B (1 2), together with 10 known compounds (3–12) were obtained EtOAc extract strain. Interestingly, alkaloids 1–4 different frameworks are characterized by presence same anthranilic acid residue. structures established detailed analyses spectroscopic data. absolute configuration resolved quantum chemistry...

10.3390/molecules26123514 article EN cc-by Molecules 2021-06-09

Background: Mobile health (mHealth) technologies have the potential to bring care closer people with otherwise limited access adequate care. However, physiological monitoring using mobile medical sensors is not yet widely used as adding biomedical mHealth projects inherently introduces new challenges. Thus far, no methodology exists systematically evaluate these implementation challenges and identify related risks. Objective: This study aimed facilitate of initiatives sensing in constrained...

10.2196/11896 article EN cc-by JMIR mhealth and uhealth 2018-12-14

Coronavirus Disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus type 2, which characterized high infectiousness and diverse clinical manifestations. They are more likely to become critical in people who have underlying diseases or immunocompromised. In the daunting task of treating patients with COVID-19, those comorbid fungal infections susceptible underdiagnosis misdiagnosis, can ultimately lead increased morbidity mortality this group patients. We report a...

10.7754/clin.lab.2024.240120 article EN Clinical Laboratory 2024-01-01

The unilateral absence of a pulmonary artery (UAPA) is very rare congenital vascular malformation. Since the first case was reported in 1868, overall incidence UAPA has been at level 1/300,000 - 1,200,000. Isolated without other cardiac anomalies rare. Here we report young woman who came to clinic with hemoptysis as main manifestation. multiple malformations finally diagnosed by DSA angiography. diagnosis and treatment experience gains are discussed combination process this patient.

10.7754/clin.lab.2024.240711 article EN Clinical Laboratory 2024-01-01

Demyelination is similar with malignancy in clinical symptoms. Magnetic resonance imaging (MRI) an important auxiliary examination the diagnosis of demyelinating diseases and malignancy. Since MRI symptoms can be difficult to distinguish demyelination from malignancy, other examinations, such as disease-specific antibodies, play role distinguishing them. Previous studies have reported antibodies patients What's more, it more confirm when malignant tumor co-occurs diseases, which has never...

10.1097/md.0000000000031003 article EN cc-by-nc Medicine 2022-10-07

ABSTRACT Measuring peripheral oxygen saturation (SpO 2 ) with pulse oximeters at the point of care is widely established. However, since SpO dependent on ambient atmospheric pressure, distribution values in populations living above 2000 m a.s.l. largely unknown. Here, we propose and evaluate a computer model to predict for pediatric permanent residents between 0 4000 Based sensitivity analysis transport parameters, created an altitude-adaptive that takes physiological adaptation into...

10.1101/334482 preprint EN cc-by-nc-nd bioRxiv (Cold Spring Harbor Laboratory) 2018-05-30

Abstract Background: To review and analyze the clinical imaging features of central giant cell granuloma patients to relevant literatures for diagnosis manifestation granuloma. Methods: 7 cases were retrospectively selected study all which confirmed by pathology had investigations. All undergone CT scan, 3 MRI scan. Detailed compared along with findings analysis was done on basis their presentation features. Results: The features, radiologic varied according site lesion. include unevenly...

10.21203/rs.3.rs-26352/v1 preprint EN cc-by Research Square (Research Square) 2020-05-06

Chronic wounds significantly impact quality of life. If not properly managed, they can severely deteriorate. Image-based wound analysis could aid in objectively assessing the status by quantifying important features that are related to healing. However, high heterogeneity types, image background composition, and capturing conditions challenge robust segmentation images. We present Detect-and-Segment (DS), a deep learning approach produce maps with generalization capabilities. In our...

10.48550/arxiv.2111.01590 preprint EN cc-by-nc-nd arXiv (Cornell University) 2021-01-01

BACKGROUND: Atherosclerotic cardiovascular disease is the leading cause of death and disability in United States other developed countries. Macrophages are major cells responsible for atherosclerotic lesion development. (-)-Epigallocatechin gallate (EGCG), a natural compound found green tea, valuable to prevent atherosclerosis. But EGCG’s low level stability, bioavailability targeting specificity body makes administering it therapeutic doses unrealistic. METHODS AND RESULTS: We have...

10.1161/circ.128.suppl_22.a18763 article EN Circulation 2013-11-26

The aim of this study is to synthesize EGCG‐loaded nanoparticles (Nano‐E) improve EGCG stability, cellular content, decrease cholesterol accumulation and inflammatory factor production in THP‐1 derived macrophages. Biocompatible biodegradable Nano–E was prepared by a phase inversion method. particle size zeta potential Nano‐E were measured using Brookhaven analyzer. Encapsulation efficiency (EE), loading content (LC), release, stability different temperatures pH, HPLC system. Cellular uptake...

10.1096/fasebj.27.1_supplement.224.5 article EN The FASEB Journal 2013-04-01

Atherosclerotic cardiovascular disease is the leading cause of death in U.S. Macrophages are major cells responsible for atherosclerotic lesion development. (−)‐Epigallocatechin gallate (EGCG) abundant green tea valuable prevention and treatment atherosclerosis. But low levels stability bioavailability limit its application human. We encapsulated EGCG into biocompatible biodegradable nanocarriers to increase cellular bioavailability. The nanoencapsulated native was measured at pH 7.2 4 °C 25...

10.1096/fasebj.26.1_supplement.646.5 article EN The FASEB Journal 2012-04-01
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