Changxu Han

ORCID: 0000-0001-9023-0667
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About
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Research Areas
  • Spine and Intervertebral Disc Pathology
  • Shoulder Injury and Treatment
  • Psoriasis: Treatment and Pathogenesis
  • Autoimmune Bullous Skin Diseases
  • Shoulder and Clavicle Injuries
  • Cervical and Thoracic Myelopathy
  • Bone health and treatments
  • T-cell and B-cell Immunology
  • Bone and Joint Diseases
  • Skin Diseases and Diabetes
  • Single-cell and spatial transcriptomics
  • Spinal Hematomas and Complications
  • Dermatology and Skin Diseases
  • Alkaline Phosphatase Research Studies
  • Bone and Dental Protein Studies
  • Bone Metabolism and Diseases
  • Obstructive Sleep Apnea Research
  • Hip disorders and treatments
  • Cutaneous lymphoproliferative disorders research
  • Fungal Biology and Applications
  • Urticaria and Related Conditions
  • Immunotherapy and Immune Responses
  • Microbial Natural Products and Biosynthesis
  • Streptococcal Infections and Treatments
  • Peroxisome Proliferator-Activated Receptors

University of Hong Kong
2022-2025

University of Hong Kong - Shenzhen Hospital
2019-2025

Second Affiliated Hospital of Inner Mongolia Medical University
2015-2023

China Medical University
2007-2008

Abstract Generalized pustular psoriasis (GPP) is considered to be a distinct clinical entity from vulgaris (PV), with different and histological manifestations. The pathogenesis of GPP has not been thoroughly elucidated, especially in those patients lacking interleukin (IL)36RN. In present study, we performed RNA sequence analysis on skin lesions 10 (4 6 without IL36RN mutation) PV mutation. Compared PV, significantly overexpressed genes were enriched IL‐17 signalling pathway ( MMP1, MMP3,...

10.1111/exd.15026 article EN Experimental Dermatology 2024-02-01

Steroid-induced osteonecrosis of the femoral head (ONFH) is a disease bone. Metabolism and genetic factors are generally considered to play an important role. The purpose this study was investigate relationship between single-nucleotide polymorphisms (SNPs) in MIR17HG MIR155HG risk steroid-induced ONFH population northern China.A total 199 patients 506 healthy controls were recruited for study. Four SNPs seven genotyped by Sequenom MassARRAY. ORs 95% CIs used evaluate these ONFH.In...

10.1186/s13018-021-02669-y article EN cc-by Journal of Orthopaedic Surgery and Research 2021-11-15

Objective To compare and analyze the differences in transcriptomics between mycelium early yeast phases of Sporothrix schenckii (S. schenckii) , to realize changes transcriptome expression profiles during mycelium-to-yeast transformation. Methods A standard strain S. (ATCC 10268) was subjected 96-hour culture with Sabouraud medium at 25 ℃ or 36-hour brain-heart infusion 37 obtain form schenckii, then, their transcriptomes were sequenced. Functional annotation performed for screened...

10.3760/cma.j.issn.0412-4030.2019.03.006 article EN Chinese Journal of Dermatology 2019-03-15

Abstract IntroductionSteroid-induced osteonecrosis of the femoral head (ONFH ) is a disease bone metabolism, and genetic factors are generally considered to play an important role. The purpose this study was investigate relationship between single nucleotide polymorphisms (SNPs) in MIR17HG MIR155HG risk steroid-induced ONFH population northern China.MethodsA total 199 patients 506 healthy controls were recruited for study. Four SNPs seven genotyped by Sequenom MassARRAY. ORs 95% CIs used...

10.21203/rs.3.rs-374738/v1 preprint EN cc-by Research Square (Research Square) 2021-04-01
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