Abstract Background Multimorbidity has become one of the main challenges in health care system. The association between prevalence, patterns multimorbidity and utilization is less often discussed China. purpose this study to examine among Chinese middle-aged older adults take into account different sociodemographic, behavioral characteristics. Based on this, implications current evidence effective intervention can be identified put practice. Methods wave 4 2018 China Health Retirement...

1-17-2 is a rat anti-human DEC-205 monoclonal antibody that induces internalization and delivers antigen to dendritic cells (DCs). The potentially clinical application of this limited by its murine origin. Traditional humanization method such as complementarity determining regions (CDRs) graft often leads decreased or even lost affinity. Here we have developed novel based on computer modeling bioinformatics analysis. First, used homology technology build the precise model Fab. A epitope...

ABCC1 belongs to the ATP-binding cassette (ABC) superfamily, which encompasses a total of 48 constituent members. has been shown be associated with growth, progression, and drug resistance various types cancer. However, impact on cancer immune infiltration pan-cancer prognosis rarely studied. Our comprehensive analysis unveiled elevated expression across cancers. overexpression consistently predicted unfavorable outcomes based TCGA data. Moreover, exhibited intricate associations diverse...

Osteoporosis, a chronic disease with no therapeutic cure, affects growing number of people as the aging population in China rapidly increases. Therefore, developing an evidence-based model health education and management for osteoporosis prevention is required. In present study, club was established, which novel prevention. A unified membership used based on digitized database. total 436 patients were randomly assigned to group or self-management control group. For group, multiple activities...

The mitral valve, which lies between the left atrium and ventricle, plays an important role in controlling uniflux of blood from to ventricle as one four human heart valves. A precise description shape valve has vital significance studying its physiological structure periodic movement. Unsatisfyingly, there is almost no unified mathematical same literature. In this paper, we present a geometric model for elastic shell with special shape. Parametric equations are provided, including anterior...

Abstract Designing and optimizing the interface of carbon fiber composites is key to improve mechanical biotribological properties. Carbon fiber‐reinforced hydroxyapatite‐epoxy matrix (CM) composites, which have excellent properties, are often used avoid artificial bone damage longevity bone. In this work, a SiC nanowires@pyrolytic (SiCnws@PyC) designed incorporated into CM SiCnws@PyC can promote bonding fiber/matrix cohesion epoxy matrix. The properties greatly improved because modification...

In this study, we constructed a novel and simple yeast surface display system with single expression vector. The newly established uses bidirectional vector carrying the AGA 1 gene driven by PGK promoter in one direction 2‐expression cassette TEF reverse direction, geneticin, G418‐resistant gene, as selection marker for transformants. Because all elements are put into vector, new is much simpler to use, there no need any genetic modification of host strains; therefore, can be used wild type...

Carbon fiber reinforced dual-matrix composites (CHM) including carbon hydroxyapatite-polymer matrix (CHMP) and hydroxyapatite-pyrolytic (CHMC) have great potential application in the field of artificial hip joints, where a combination high mechanical strength excellent biotribological property are required. In this work, graphene-silicon nitride nanowires (Graphene-Si3N4nws) interlocking interfacial enhancement were designed constructed into CHM for boosting properties. The graphene Si3N4nws...

Abstract Background and purpose Alcohol-induced osteonecrosis of the femoral head (ONFH) is a complex heterogeneous disease. Genetic factors epigenetic modifications are one pathogenesis However, influence on disease has not been systematically studied. Our research aims to determine methylation changes alcohol-induced ONFH. Methods An analytical cross-sectional study Chinese male population (50 ONFH patients 50 controls). The EpiTYPER Sequenom MassARRAY platform was used detect DNA status...

Globally, blood pressure management strategies were ineffective, and a low percentage of patients receiving hypertension treatment had their controlled. In this study, we aimed to build medication prediction model by correlating patient attributes with medications help physicians quickly rationally match appropriate medications. We collected clinical data from elderly hypertensive during hospitalization combined statistical methods machine learning (ML) algorithms filter out typical...

Multimorbidity has become a global public health concern. Knowledge about the prevalence and patterns of multimorbidity will provide essential information for intervention clinical management. This study aimed to examine gender socioeconomic differences in among nationally representative sample middle-aged older Chinese individuals.Data were obtained from 2018 wave China Health Retirement Longitudinal Study. Latent class analysis was conducted discriminate patterns. Multinomial logit...

Steroid-induced osteonecrosis of the femoral head (ONFH) is a disease bone. Metabolism and genetic factors are generally considered to play an important role. The purpose this study was investigate relationship between single-nucleotide polymorphisms (SNPs) in MIR17HG MIR155HG risk steroid-induced ONFH population northern China.A total 199 patients 506 healthy controls were recruited for study. Four SNPs seven genotyped by Sequenom MassARRAY. ORs 95% CIs used evaluate these ONFH.In...

Objectives The objective of this study was to examine the impact athletes achieving excellence at different ages (excellent age) on their subsequent performance development. aim deepen understanding interplay among talent, training, and athletes’ Additionally, aimed provide insights for athletics coaches better identify talent devise more effective personalized long-term training plans. Design This a cross-sectional study. Method A hierarchical linear model employed analyze correlation...

Abstract The Research Experiences for Undergraduates (REU) program plays a crucial role in fostering research interests among undergraduate students, motivating them to pursue advanced degrees Science, Technology, Engineering, and Mathematics (STEM) fields, developing diverse, skilled workforce STEM careers. Annually, the National Science Foundation (NSF) awards approximately 170-190 REU grants. funding sites often reflects current trends research. Our study aims examine sites' contributions...

Abstract Aim To understand the status of internalized stigma in patients with rheumatoid arthritis (RA) and explore its relationship self‐esteem, social support, coping style. Methods This cross‐sectional study selected RA who visited Rheumatology Immunology Department a tertiary hospital from May 2022 to 2023. The Chinese versions Internalized Stigma Mental Illness Scale‐Rheumatoid Arthritis (ISMI‐RA), Social Support Rating Scale, Rosenberg Self‐Esteem Medical Coping Style Questionnaire...

Abstract Background : Steroid-induced osteonecrosis of the femoral head (ONFH) is aseptic necrosis caused by glucocorticoid use. Once necrotic occurs, it irreversibly affects quality life seriously. Studies have shown that susceptibility to steroid-induced ONFH likely be related variation miRNA coding genes. Therefore, this study aimed was investigate effect MIR3142HG on ONFH. Methods Agena MassARRAY used genotype gene rs1582417, rs2431689, rs7727155 and rs17057846 in 199 patients 506...

<b><i>Background:</i></b> Steroid-induced osteonecrosis of the femoral head (ONFH) is aseptic necrosis caused by glucocorticoid use. Once necrotic occurs, it irreversibly affects quality life seriously. Studies have shown that susceptibility to steroid-induced ONFH likely be related variation miRNA-coding genes. Therefore, this study aimed was investigate effect <i>MIR3142HG</i> on ONFH. <b><i>Methods:</i></b> Agena MassARRAY used...

Abstract Background Depressive symptoms is a relatively common mental disorder, which can lead to serious physical, psychological, and social problems. This study aimed explore the associations between self-efficacy, e-Health literacy depressive among Chinese college students evaluate effect of as potential mediator. Methods By using cluster sampling method, 1500 from two universities were recruited in Nantong City, China. Participants' demographic characteristics, collected. OLS was used...

Abstract Background: The pathogenesis of non-traumatic osteonecrosis the femoral head (ONFH ) is related to interruption blood supply caused by lipid metabolism and hypercoagulability. purpose this study was explore relationship between clinical biochemical parameters ONFH. Methods: basic information indexes 1292 patients with non- traumatic ONFH 1880 healthy controls were collected. SPSS software (version 22.0) used process analyze data. T-test for quantitative analysis. Chi-square test...