A5053442865- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- CAR-T cell therapy research
- Cancer Research and Treatments
- Cancer Immunotherapy and Biomarkers
Universidad de Santiago de Chile
2021
Fundación Ciencia and Vida
2018-2019
Abstract Tissue-resident memory CD8 + T (Trm) cells mediate potent local innate and adaptive immune responses play a central role against solid tumors. However, whether Trm cross-talk with dendritic (DCs) to support anti-tumor immunity remains unclear. Here we show that antigen-specific activation of skin leads maturation migration draining lymph nodes cross-presenting dermal DCs. Tumor rejection mediated by triggers the spread cytotoxic cell tumor-derived neo- self-antigens via These...
Memory CD8+ T cell responses have the potential to mediate long-lasting protection against cancers. Resident memory (Trm) cells stably reside in non-lymphoid tissues and superior innate adaptive immunity pathogens. Emerging evidence indicates that Trm develop human solid cancers play a key role controlling tumor growth. However, specific contribution of anti-tumor is incompletely understood. Moreover, clinically applicable vaccination strategies efficiently establish remain largely...
Active immunotherapy against cancer is based on immune system stimulation, triggering efficient and long-lasting antigen-specific responses. Immunization strategies using whole dead cells from tumor tissue, containing specific antigens inside, have become a promising approach, providing lymphocyte activation through dendritic (DCs). In this work, we generate CT26, E.G7, EL4 live as antigen sources, which termed immunogenic cell bodies (ICBs), generated by simple cost-efficient...