A5025580175- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- CAR-T cell therapy research
- Virus-based gene therapy research
- Erythropoietin and Anemia Treatment
- Cancer Immunotherapy and Biomarkers
- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Asthma and respiratory diseases
- Single-cell and spatial transcriptomics
- Chronic Lymphocytic Leukemia Research
- Multiple Sclerosis Research Studies
- Pharmaceutical Economics and Policy
- Epigenetics and DNA Methylation
- Cytomegalovirus and herpesvirus research
- Cancer, Stress, Anesthesia, and Immune Response
- Nanowire Synthesis and Applications
- Health Systems, Economic Evaluations, Quality of Life
- NF-κB Signaling Pathways
- Tryptophan and brain disorders
- Psoriasis: Treatment and Pathogenesis
- Neurological Complications and Syndromes
- Cancer-related gene regulation
- Central Venous Catheters and Hemodialysis
Institute of Cancer Research
2025
Fundación Ciencia and Vida
2016-2023
University College London
2023
Cancer Institute (WIA)
2023
Centre Hospitalier Universitaire de Montpellier
2005-2006
Abstract Tissue-resident memory CD8 + T (Trm) cells mediate potent local innate and adaptive immune responses play a central role against solid tumors. However, whether Trm cross-talk with dendritic (DCs) to support anti-tumor immunity remains unclear. Here we show that antigen-specific activation of skin leads maturation migration draining lymph nodes cross-presenting dermal DCs. Tumor rejection mediated by triggers the spread cytotoxic cell tumor-derived neo- self-antigens via These...
Background Chimeric antigen receptor (CAR) T cells have shown remarkable results against B-cell malignancies, but only a minority of patients long-term remission. The metabolic requirements both tumor and activated result in production lactate. export lactate is facilitated by expression monocarboxylate transporter (MCTs). CAR express high levels MCT-1 MCT-4 on activation, while certain tumors predominantly MCT-1. Methods Here, we studied the combination CD19-specific T-cell therapy with...
Abstract Dopamine receptor D3 (DRD3) expressed on CD4+ T cells is required to promote neuroinflammation in a murine model of Parkinson’s disease. However, how DRD3 signaling affects cell–mediated immunity remains unknown. In this study, we report that TCR stimulation mouse induces expression, regardless the lineage specification. Importantly, functional analyses performed vivo using adoptive transfer OVA-specific OT-II into wild-type recipients show deficiency results attenuated...
Memory CD8+ T cell responses have the potential to mediate long-lasting protection against cancers. Resident memory (Trm) cells stably reside in non-lymphoid tissues and superior innate adaptive immunity pathogens. Emerging evidence indicates that Trm develop human solid cancers play a key role controlling tumor growth. However, specific contribution of anti-tumor is incompletely understood. Moreover, clinically applicable vaccination strategies efficiently establish remain largely...
The dual potential to promote tolerance or inflammation self-antigens makes dendritic cells (DCs) fundamental players in autoimmunity. Previous results have shown that stimulation of dopamine receptor D5 (DRD5) DCs potentiates their inflammatory behaviour, favouring the development experimental autoimmune encephalomyelitis (EAE). Here we aimed decipher underlying mechanism and test its relevance multiple sclerosis (MS) patients. Our data shows DRD5-deficiency confined EAE mice resulted...
Despite the approval of several new treatments for patients with B-cell lymphoma, there is still a large unmet need. Diffuse lymphoma (DLBCL) and Follicular (FLs) are two most common subtypes, accounting approximately 50% all cases. EZH2 heterozygous gain-of-function somatic driver mutations frequently found in Germinal Center B cell (GCB) DLBCLs FLs. An inhibitor has shown durable responses relapsed or refractory FL, however considerable fraction did not show an objective response. To...
Abstract High-dose cyclophosphamide (Cy) and G-CSF are widely used to mobilize hemopoietic stem cells for treating patients with high-dose chemotherapy autologous cell transplantation (ASCT). Because lymphocyte count in the graft collected after Cy-G-CSF treatment is an independent survival factor ASCT multiple myeloma, our purpose was study how affects phenotype function of T myeloma. Cy induced a 3-fold decrease counts slow partial recovery one-third at time collection. did not affect...
Background and AimsCD4+ T cells constitute central players in inflammatory bowel diseases (IBDs), driving inflammation the gut mucosa. Current evidence indicates that CCR9 integrin α4β7 are necessary sufficient to imprint colonic homing on CD4+ upon inflammation. Interestingly, dopaminergic signaling has been previously involved leukocyte homing. Despite dopamine levels strongly reduced inflamed mucosa, role of remains unknown. Here, we study how affects inflammation.MethodsGut was induced...
Dendritic cells (DCs) have the ability to induce tolerance or inflammation in response self-antigens, which makes them fundamental players autoimmunity. In this regard, immunogenic DCs produce IL-12 and IL-23 favouring acquisition of Th1 Th17 inflammatory phenotypes, respectively, by autoreactive CD4+ T-cells, thus promoting Conversely, tolerogenic IL-10 TGF-β, inducing generation T-cells with suppressive activity (Treg), promote self-constituents. Previous studies shown that STAT3...
Gallbladder cancer (GBC) is commonly diagnosed at late stages when conventional treatments achieve only modest clinical benefit. Therefore, effective for advanced GBC are needed. In this context, the administration of T cells genetically engineered with chimeric antigen receptors (CAR) has shown remarkable results in hematological cancers and being extensively studied solid tumors. Interestingly, tumors express canonical tumor-associated antigens, including carcinoembryonic (CEA). However,...
Dopamine has emerged as an important regulator of immunity. Recent evidence shown that signalling through low-affinity dopamine receptors exerts anti-inflammatory effects, whilst stimulation high-affinity potentiates immunity in different models. However, the dopaminergic regulation CD8+ T-cells anti-tumour remains poorly explored. Here, we studied role receptor D3 (DRD3), which displays highest affinity for dopamine, function and its consequences immune response. We observed deficiency Drd3...