A5024828444- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Animal Disease Management and Epidemiology
- Virology and Viral Diseases
- CAR-T cell therapy research
- Influenza Virus Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
Fundación Ciencia and Vida
2013-2019
Universidad Andrés Bello
2013
Abstract Tissue-resident memory CD8 + T (Trm) cells mediate potent local innate and adaptive immune responses play a central role against solid tumors. However, whether Trm cross-talk with dendritic (DCs) to support anti-tumor immunity remains unclear. Here we show that antigen-specific activation of skin leads maturation migration draining lymph nodes cross-presenting dermal DCs. Tumor rejection mediated by triggers the spread cytotoxic cell tumor-derived neo- self-antigens via These...
Memory CD8+ T cell responses have the potential to mediate long-lasting protection against cancers. Resident memory (Trm) cells stably reside in non-lymphoid tissues and superior innate adaptive immunity pathogens. Emerging evidence indicates that Trm develop human solid cancers play a key role controlling tumor growth. However, specific contribution of anti-tumor is incompletely understood. Moreover, clinically applicable vaccination strategies efficiently establish remain largely...