A5002853844- HIV Research and Treatment
- Immune Cell Function and Interaction
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Complement system in diseases
- Immunotherapy and Immune Responses
- Ethics in Clinical Research
- Cell Adhesion Molecules Research
- Telemedicine and Telehealth Implementation
- HIV-related health complications and treatments
- Malaria Research and Control
- Peripheral Neuropathies and Disorders
- Hematopoietic Stem Cell Transplantation
- Advanced biosensing and bioanalysis techniques
- Infectious Encephalopathies and Encephalitis
- Diet, Metabolism, and Disease
- Hematological disorders and diagnostics
- Biochemical Analysis and Sensing Techniques
- Mycobacterium research and diagnosis
- COVID-19 and Mental Health
- Diabetes Treatment and Management
- Regulation of Appetite and Obesity
- Fungal Infections and Studies
- COVID-19 diagnosis using AI
- Intensive Care Unit Cognitive Disorders
Burnet Institute
2007-2024
Melbourne Clinic
2024
Peninsula Health
2022
Peter Doherty Institute
2021
The Royal Melbourne Hospital
2020-2021
The Alfred Hospital
2018
Western Health
2018
Royal Brisbane and Women's Hospital
2013
Monash University
2007-2013
Mater Health Services
2011
Abstract HIV-1 persists in peripheral blood monocytes individuals receiving highly active antiretroviral therapy (HAART) with viral suppression, despite these cells being poorly susceptible to infection vitro. Because very few harbor vivo, we considered whether a subset of might be more permissive infection. We show that minor CD16+ monocyte preferentially harbors infected on HAART when compared the majority (CD14highCD16−). confirmed this by vitro experiments showing were CCR5-using strains...
CD163, a haptoglobin-hemoglobin (Hp-Hb) scavenger receptor, expressed by monocytes and macrophages, is important in resolution of inflammation. Age-related non-AIDS co-morbidities HIV-infected individuals, particularly dementia cardiovascular disease, result part from effects HIV-1 infection on monocyte macrophage biology. CD163 co-expression CD14+CD16++ has been proposed as useful biomarker for disease progression the presence HIV associated dementia. Here we investigated expression subsets...
Abstract Tetraspanins are differentially expressed in monocyte subsets and modified by inflammatory situations including HIV-1 infection. a family of membrane-organizing proteins that mediate diverse functions. Little is known their expression or function myeloid cells. Here, CD9, CD53, CD63, CD81, tetraspanins have been implicated pathogenesis, were characterized normal subsets, MDM, HIV-1-infected donors. We show with higher CD9 CD63 lower CD53 CD81 levels on CD14++CD16− monocytes compared...
HIV-1 infection increases the risk and severity of malaria by poorly defined mechanisms. We investigated effect HIV-1Ba-L monocyte-derived macrophages (MDM) on phagocytosis opsonised P. falciparum infected erythrocytes (IE) subsequent proinflammatory cytokine secretion. Compared to mock-infected MDM, significantly inhibited IE (median (IQR) (10 (0–28) versus (34 (27–108); internalised/100 MDM; p = 0.001) decreased secretion IL-6 (1,116 (352–3,387) 1,552 (889–6,331); pg/mL; 0.0078) IL-1β (16...
To determine the impact of persistent symptoms after coronavirus disease 2019 (COVID-19) in an Australian population.
Abstract Benign acute childhood myositis ( BACM ) is a post‐respiratory tract infection condition of school‐age children. Presentation typically with onset calf pain and tenderness refusal to walk or altered gait during the convalescent period an influenza A B infection. We describe unique cluster children following human parainfluenza 1 virus, no evidence commonly missed diagnosis in presenting emergency department. This first report virus type‐1 associated . discuss presentation, clinical...
Serological assays for SARS-CoV-2 infection are now widely available use in diagnostic laboratories. Limited data on the performance characteristics different settings, and at time periods remote from initial infection. Validation of Abbott (Architect IgG), DiaSorin (Liaison S1/S2 IgG) Roche (Cobas Elecsys Anti-SARS-CoV-2) was undertaken utilising 217 serum samples 131 participants up to 7 months following COVID-19 The were implemented into routine laboratory workflow, with outcomes reported...
Mycobacterium abscessus complex (MAbsC) is a significant management dilemma when taking care of patients with cystic fibrosis (CF).We undertook retrospective cohort analysis all CF in whom MAbsC was isolated from 2005 to 2014. The natural history determined and clinical factors examined an attempt predict transient compared persistent colonization.No correlation found between recurrent isolation such as body mass index, respiratory function, or age. Over two-thirds our cleared colonization...
Background. Poststorage, leuko-depleted blood transfusions have been associated with increased postoperative infections and improved allograft survival compared prestorage leukocyte-depleted transfusion. Although the mechanism of this phenomenon remains to be fully elucidated, it is clear that immunomodulatory effect mediated by leukocytes/platelets or their products. Method. The aim study was investigate in vitro effects pre- poststorage plasma (LDP) buffy coat LDP on T-cell proliferation...
Citation: Whyler N, Atkins L, Hogg P, Leong A, Metcalfe J, Scoullar M and Tippett E (2024) Harnessing the Benefits of Telehealth in Long COVID Service Provision. Public Health Rev 45:1606948. doi: 10.3389/phrs.2024.1606948
Post-acute COVID-19 condition (PACC) - also known as long COVID is a serious and growing problem in primary health. This letter describes the work of Victorian Post-Acute Study (VPACS) group, which comprises clinician researchers, basic scientists consumers. Two key priorities for PACC research Australia are identified discussed: (1) establishment patient registries data linkage; (2) consolidation clinical guidelines. Collaboration between consumers, clinicians institutions must be...