A5031608311- Angiogenesis and VEGF in Cancer
- Cancer, Hypoxia, and Metabolism
- Virus-based gene therapy research
- Renal cell carcinoma treatment
- Toxin Mechanisms and Immunotoxins
- Cytokine Signaling Pathways and Interactions
- Immunotherapy and Immune Responses
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Microbial Inactivation Methods
- Kruppel-like factors research
- Cancer Genomics and Diagnostics
- Multiple Myeloma Research and Treatments
- Cancer Research and Treatments
- Developmental Biology and Gene Regulation
- Cancer Diagnosis and Treatment
- BRCA gene mutations in cancer
- Cancer Cells and Metastasis
- Immune Cell Function and Interaction
- Prostate Cancer Treatment and Research
- CRISPR and Genetic Engineering
- Ovarian cancer diagnosis and treatment
- Histone Deacetylase Inhibitors Research
- Oral and gingival health research
- S100 Proteins and Annexins
- Cancer-related molecular mechanisms research
Istituto Oncologico Veneto
2009-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2009-2024
Institut Català d'Oncologia
2011-2020
Institut d'Investigació Biomédica de Bellvitge
2012-2020
University of Padua
2004-2014
Institut Català d'Ornitologia
2012
Center for Innovation
2012
University of Belgrade
2012
Medical University of Vienna
2012
University Medical Center of the Johannes Gutenberg University Mainz
2011
Cholangiocarcinoma (CCA) is characterized by an abundant stromal reaction. Cancer-associated fibroblasts (CAFs) are pivotal in tumor growth and invasiveness represent a potential therapeutic target. To understand the mechanisms leading to CAF recruitment CCA, we studied (1) expression of epithelial-mesenchymal transition (EMT) surgical CCA specimens cells, (2) lineage tracking enhanced green fluorescent protein (EGFP)-expressing human male cell line (EGI-1) after xenotransplantation into...
The Notch ligand Dll4 has a recognized role during both physiologic and tumor angiogenesis, as it contributes to regulate activity in endothelial cells (EC). effects of on signaling expressing receptors remain, however, largely unknown. Here, we report that escape human T-cell acute lymphoblastic leukemia (T-ALL) or colorectal cancer from dormancy is associated with expression the microenvironment increased Notch3 cells. was expressed at early time points angiogenic process, its preceded...
The side population (SP), recently identified in several normal tissues and a variety of tumors based on its ability to extrude some fluorescent dyes, may comprise cells endowed with stem cell features. In this study, we investigated the presence SP epithelial ovarian cancer found it 9 27 primary tumor samples analyzed, as well 4 6 cultures from xenotransplants. one xenograft bearing large fraction were characterized detail. had higher proliferation rates, much less apoptotic compared non-SP...
Cholangiocarcinoma (CCA) carries a severe prognosis because of its strong invasiveness and early metastasization. In several patients, otherwise eligible for surgical resection, micrometastasis are already present at the time surgery. The mechanisms responsible CCA unclear. S100A4, member S100 family small Ca(2+)-binding proteins, is expressed in mesenchymal cells, regulates cell motility types, some epithelial cancers. Thus, we aimed to study role S100A4 expression was studied by...
Increased Notch1 activity has been observed in intestinal tumours, partially accomplished by β-catenin-mediated up-regulation of the Notch ligand Jagged-1. Whether further mechanisms activation exist and other receptors might be involved is unclear. Microarray data indicated that Notch3 transcript levels are significantly up-regulated primary metastatic CRC samples compared to normal mucosa. Moreover, protein was expressed at strong/moderate 19.7% 158 analysed, weak 51.2% samples. Intrigued...
Abstract VEGF antagonists are now widely used cancer therapeutics, but predictive biomarkers of response or toxicity remain unavailable. In this study, we analyzed the effects anti-VEGF therapy on tumor metabolism and therapeutic by using an integrated set imaging techniques, including bioluminescence metabolic imaging, 18-fluorodeoxyglucose positron emission tomography, MRI spectroscopy. Our results revealed that caused a dramatic depletion glucose exhaustion ATP levels in tumors, although...
Activation of the NOTCH pathway occurs commonly in T acute lymphoblastic leukemia (T-ALL) mainly due to mutations NOTCH1 or alterations FBW7 and is involved regulation cell proliferation survival. Since hit different domains receptor, they are predicted heterogeneously perturb ligand-induced activity. Moreover, T-ALL cells also co-express NOTCH3 receptors which could be triggered by ligands. In this study, we aimed investigate role DLL4 signaling context types mutation wild-type as well...
The IL-12Rβ2 gene is expressed in human mature B cell subsets but not transformed lines. Silencing of this may be advantageous to neoplastic cells. Our objective was investigate the mechanism(s) and functional consequence(s) silencing primary tumors Purified tumor cells from 41 patients with different chronic lymphoproliferative disorders, representing counterparts major subsets, tested negative for expression. Hypermethylation a CpG island noncoding exon 1 associated malignant Treatment DNA...
The IL-12Rβ2 gene is expressed in human mature B cell subsets but not transformed lines. Silencing of this may be advantageous to neoplastic cells. Our objective was investigate the mechanism(s) and functional consequence(s) silencing primary tumors Purified tumor cells from 41 patients with different chronic lymphoproliferative disorders, representing counterparts major subsets, tested negative for expression. Hypermethylation a CpG island noncoding exon 1 associated malignant Treatment DNA...
Ovarian cancer represents a suitable disease for gene therapy because of the containment neoplastic cells in peritoneal cavity even at advanced tumor stages. The aim this study was to investigate whether intraperitoneal administration lentiviral vector encoding murine interferon-alpha (LV-IFN) could have therapeutic activity transplantable ovarian model. Multiple injections low amounts LV-IFN into severe combined immunodeficiency (SCID) mice bearing IGROV-1 or OC316 elicited remarkable...
Interferon (IFN)-α is a cytokine with marked therapeutic activity in transplantable tumor models, that part due to angiogenesis inhibition. Aim of this study was investigate the effects IFN-α during early phases development transgenic adenocarcinoma mouse prostate (TRAMP) model. To provide sustained production, TRAMP mice were injected intraperitoneally lentiviral vectors. administration resulted rapid and protracted upregulation IFN-α-regulated genes associated antiangiogenic...
Bone marrow mesenchymal stromal cells (BM-MSCs) may survive and proliferate in the presence of cycling neoplastic cells. Exogenously administered MSCs are actively incorporated tumor as fibroblasts, thus competing with local cell precursors. For this reason, have been suggested a suitable carrier for gene therapy strategies, they can be genetically engineered genes encoding biologically active molecules that inhibit proliferation enhance antitumor immune response. We used BM-MSCs murine...
Article5 November 2020Open Access Source DataTransparent process Kidney cancer PDOXs reveal patient-specific pro-malignant effects of antiangiogenics and its molecular traits Lidia Moserle Tumor Angiogenesis Group, ProCURE Program, Catalan Institute Oncology, OncoBell IDIBELL, Barcelona, SpainThese authors contributed equally to this work Search for more papers by author Roser Pons Mar Martínez-Lozano Spain Gabriela A Jiménez-Valerio August Vidal Department Pathology, University Hospital...
Abstract Classification of variants in the BRCA1 and BRCA2 genes has a major impact on clinical management subjects at high risk for breast ovarian cancer. The identification pathogenic variant allows early detection/prevention strategies healthy carriers as well targeted treatments patients affected by BRCA -associated tumors. c.9227G>T p.(Gly3076Val) recurs families from Northeast Italy is rarely reported international databases. This substitutes evolutionary invariant glycine 3076 with...