A5000112970- Neonatal Respiratory Health Research
- Zebrafish Biomedical Research Applications
- Cardiac Structural Anomalies and Repair
- Mechanical Circulatory Support Devices
- Congenital Heart Disease Studies
- Aquaculture disease management and microbiota
- Pharmacological Effects and Toxicity Studies
- Hepatitis C virus research
- DNA Repair Mechanisms
- Cancer-related molecular mechanisms research
- Muscle metabolism and nutrition
- vaccines and immunoinformatics approaches
- Vascular Malformations and Hemangiomas
- Hemodynamic Monitoring and Therapy
- Diet and metabolism studies
- Ectopic Pregnancy Diagnosis and Management
- Bacillus and Francisella bacterial research
- Congenital Diaphragmatic Hernia Studies
- Cardiovascular Disease and Adiposity
- Biochemical and Molecular Research
- Cardiac Fibrosis and Remodeling
- Cardiovascular Function and Risk Factors
- Trauma Management and Diagnosis
- Cell Adhesion Molecules Research
- Histone Deacetylase Inhibitors Research
Tongren Hospital
2025
Shanghai Jiao Tong University
2025
Fujian Medical University
2022-2024
Fujian Provincial Hospital
2024
Shanghai Children's Medical Center
2022-2024
Xianning Central Hospital
2024
Hubei University of Science and Technology
2024
Fujian Women and Children Hospital
2022
Fuzhou Maternity and Child Health Care Hospital
2020-2022
First Affiliated Hospital of Jiangxi Medical College
2017
Abstract R-loops are prevalent in mammalian genomes and involved many fundamental cellular processes. Depletion of BRCA2 leads to aberrant R-loop accumulation, contributing genome instability. Here, we show that ZFP281 cooperates with preventing accumulation facilitate DNA replication embryonic stem cells. depletion reduces PCNA levels on chromatin impairs replication. Mechanistically, demonstrate can interact BRCA2, is enriched at G/C-rich promoters requires both PRC2 for its proper...
The association between dietary carbohydrate intake and hyperlipidemia remained incompletely understood. This study aimed to explore the risk of among reproductive-aged women in US.
Objective: investigating the influence of hepatitis C virus F protein deletion on viral replication and pathogenic infection results were analyzed.Methods: experimental method selected biochemical methods, first step, preparation RNA transcript; second according to result correlation detection culture experiments, including: PCR technology, infectious replication, immunofluorescence, transfection, etc.Finally, relevant collate, record analyze.Results: introduction mutant gene expression...
Abstract Background: Reprogramming of metabolism is illustrated in many types cancer and associated with the clinical outcomes patients. However, prognostic significance pyrimidine signaling pathway patients lung adenocarcinoma (LUAD) unclear.Methods: Using Gene Expression Omnibus (GEO) The Cancer Genome Atlas (TCGA) datasets, we determined metabolic rate limiting enzymes cancer. enrichment was analyzed by gene set analysis (GSEA). expression profiles were identified from Affymetrix data...
Abstract Objective: To investigate the incidence and risk factors of acute renal injury (AKI) after cardiopulmonary bypass (CPB) cardiac surgery in infants with congenital heart disease(CHD). Methods: Single-center data from a total 613 disease who underwent cardiothoracic Fujian Union Hospital.The included patients were divided into two groups according to occurrence AKI: AKI group (n = 68) non-AKI 92). We obtained clinical electronic hospitalization information system laboratory database....
Abstract The widespread SARS-CoV-2 in humans results the continuous emergence of new variants. Recently emerged Omicron variant with multiple spike mutations sharply increases risk breakthrough infection or reinfection, highlighting urgent need for vaccines broad-spectrum antigenic coverage. Using inter-lineage chimera and mutation patch strategies, we engineered a recombinant monomeric (STFK1628x), which showed high immunogenicity mutually complementary antigenicity to its prototypic form...
Objective: This study aimed to evaluate the effects of pulmonary surfactant (PS) combined with high-frequency oscillatory ventilation (HFOV) or conventional mechanical (CMV) in infants acute respiratory distress syndrome (ARDS) after congenital cardiac surgery. Method: A total 61 ARDS were eligible and randomized CMV + PS group (n= 30) HFOV 31) between January 2020 December 2020. The primary outcomes improvement arterial blood gas analysis. incidence duration, length hospitalization,...
Abstract Background The fimbrin protein family contains a variety of proteins, which Plastin1 (PLS1) is an important member. latest researches show that variations in the coding region PLS1 gene related to development deafness. However, it remains unknown about molecular mechanism deafness caused by variants. Methods whole exome sequencing was performed on affected members and healthy ones identify pathogenic variants, followed sanger sequencing. Minigene assay conducted investigate impact...
Heart failure is a complex clinical syndrome in which ventricular filling or ejection capacity impaired due to structural functional diseases of the heart. In order establish stable heart model, we investigated cardiac parameters rats with abdominal aortic contraction and normal rats, including left posterior wall diameter (LVPWd), interventricular septum thickness end-diastolic (IVSd), (LVEDd), fraction (LVEF), fractional shortening (LVFS). Rats were randomly divided into experimental group...
Objective: Factors leading to an unplanned return the cardiac intensive care unit (CICU) in children after congenital heart disease and their impact on mortality have not been well characterized. We sought determine incidence outcomes of CICU. A secondary objective was identify risk factors. Methods: Retrospective analysis registration data collected by our unit. The study subjects included postoperative patients with who survived initial transfer out Patients unexpectedly returned CICU due...