A5036419500- Lymphoma Diagnosis and Treatment
- Clinical Laboratory Practices and Quality Control
- Eosinophilic Disorders and Syndromes
- Acute Myeloid Leukemia Research
- Innovations in Medical Education
- Chronic Myeloid Leukemia Treatments
- Viral-associated cancers and disorders
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Zebrafish Biomedical Research Applications
- CNS Lymphoma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Health and Medical Research Impacts
- Multiple Myeloma Research and Treatments
- Acute Lymphoblastic Leukemia research
- Chronic Lymphocytic Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Glycosylation and Glycoproteins Research
- Drug-Induced Adverse Reactions
- Salivary Gland Disorders and Functions
- Hematological disorders and diagnostics
- Testicular diseases and treatments
- Bone and Joint Diseases
- Caveolin-1 and cellular processes
- Clinical Reasoning and Diagnostic Skills
- Anatomy and Medical Technology
Oklahoma City University
2021
University of Oklahoma Health Sciences Center
2016-2021
University of Oklahoma Medical Center
2021
Precursor-B cell acute lymphoblastic leukemia (pre-B ALL) is the most common pediatric cancer, but there are no useful zebrafish pre-B ALL models. We describe first highly- penetrant ALL, driven by human MYC. Leukemias express B lymphoblast-specific genes and distinct from T (T-ALL)—which these fish also develop. Zebrafish shares in vivo features expression profiles with differ T-ALL or normal cells. These animals exhibit aberrant lymphocyte development. As only robust model example where...
Drug-induced hypersensitivity syndrome (DIHS; also known as drug reaction with eosinophilia and systemic symptoms, or DRESS) is a rare, potentially life-threatening condition that typically presents 2–8 weeks after exposure fever, rash, organ dysfunction, lymphadenopathy. Here, we describe the case of an 18-year-old African American female who presented cervical lymphadenopathy, fevers, macular rash. A PET scan showed diffuse hypermetabolic lymphadenopathy suggestive lymphoma, involvement...
Kikuchi-Fujimoto disease (KFD), or necrotizing histiocytic lymphadenitis, is a rare cause of lymphadenopathy and fever. Although the clinical course usually benign, KFD often mistaken for malignancy infection. Recognition typical atypical cases necessary to avoid unnecessary interventions. Here we report an presentation with diffuse leukocytosis associated high levels circulating Epstein-Barr viral DNA.
Medical practice requires physicians to have a broad understanding of the basic sciences, competent clinical skills, and an ability in evolving health systems cost-effective evidence-based manner. Essential medicine is common laboratory tests use them effectively. The Laboratory Tests for Education (ELTME) concise document explaining pathophysiology context each test was developed response expressed need from medical students, residents fellows, educators. ELTME linked Pathology Competencies...
*Jimmy Everest Section of Pediatric Hematology/Oncology, Department Pediatrics, University Oklahoma Health Sciences Center Children's Hospital †Department Pathology, City, OK The authors declare no conflict interest.
Objective To better understand the role of B cells, potential mechanisms responsible for their aberrant activation, and production autoantibodies in pathogenesis Sjögren's syndrome (SS), this study explored patterns selection pressure sites N ‐glycosylation acquired by somatic mutation (ac ‐glyc) IgG variable (V) regions antibody‐secreting cells (ASCs) isolated from minor salivary glands patients with SS non‐SS control sicca symptoms. Methods A novel method to produce characterize...
Abstract Precursor-B cell acute lymphoblastic leukemia (pre-B ALL) is the most common pediatric cancer, but there are no useful zebrafish pre-B ALL models. We describe first highly-penetrant ALL, driven by human MYC . Leukemias express B lymphoblast-specific genes and distinct from T (T-ALL)—which these fish also develop. Zebrafish shares in vivo features expression profiles with differ T-ALL or normal cells. These animals exhibit aberrant lymphocyte development. As only robust model example...
Diffuse large B cell lymphoma (DLBCL), currently the most common type of non-Hodgkin (NHL), is an aggressive neoplasm that typically presents in older adults as a rapidly enlarging mass. The mass represents lymph node, although extranodal disease can occur significant percentage (40%) cases. sites involvement include gastrointestinal tract and skin; primary bladder only 0.2% lymphomas. We report case diffuse occurring 83-year-old gentleman with initial presentation hematuria. This displayed...
D-2-hydroxyglutaric aciduria (D-2-HGA) is a rare metabolic disorder characterized by developmental delay, hypotonia, and bi-allelic mutations in D-2-hydroxyglutarate dehydrogenase (D2HGDH) or single gain-of-function mutation isocitrate 2 (IDH2). Metaphyseal chondromatosis with (MC-HGA) type of D-2-HGA that has been previously reported ten patients (OMIM 614875), three whom had somatic mosaicism for R132 variants 1 (IDH1). We describe 3-year-old boy MC-HGA who subsequently developed acute...
There is often limited time allocated to teaching laboratory medicine medical students. Without adequate and context, it can be difficult for students learn appropriate uses limitations of tests. Introducing the laboratories test methods may help them these concepts, but physical tours are organize large groups, especially during coronavirus disease 2019 pandemic.We created virtual consisting short video clips voiceover PowerPoint slides teach about tests used diagnose hematologic...
Mukherjee, Sarbajit; Ibrahimi, Sami; Scordino, Teresa; Cherry, Mohamad Author Information
Abstract Introduction/Objective PathElective.com was founded as a means of combating stagnating resident and medical student education due to halting in-person educational activities during the COVID-19 pandemic. The site has since grown be included in training programs at numerous institutions across world, serving unique delivering high-quality trackable laboratory medicine education. Methods/Case Report PathElective website developed using Squarespace, video lectures were recorded by each...
Cyclic neutropenia has been rarely associated with chronic inflammation and development of reactive AA amyloidosis. We report a family cyclic renal thyroid amyloid. A 12-year-old female presented thyromegaly, recurrent aphthous ulcers, severe neutropenia, failure. Renal biopsies revealed abundant amyloid deposition. Presence heterozygous ELANE c.358 A>T gene mutation p.I120F variant autosomal dominant inheritance confirmed the diagnosis neutropenia. The patient's father also had amyloidosis...
Medical Education Program Highlights The systems-based preclinical curriculum at the University of Oklahoma College Medicine emphasizes connections between basic and clinical sciences through coursework designed to promote learning retention, develop early skills, provide students with enrichment experiences in medical humanities. Depending on which track they selected during admissions process, take all 4 years either City academic center campus or Tulsa School Community where core is...