A5017658612- Metal complexes synthesis and properties
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Metal-Catalyzed Oxygenation Mechanisms
- Magnetism in coordination complexes
- Crystal structures of chemical compounds
- Crystallography and molecular interactions
- Synthesis and Characterization of Heterocyclic Compounds
- Oxidative Organic Chemistry Reactions
- Porphyrin and Phthalocyanine Chemistry
- Vanadium and Halogenation Chemistry
- Toxoplasma gondii Research Studies
- Free Radicals and Antioxidants
- Heme Oxygenase-1 and Carbon Monoxide
- Research on Leishmaniasis Studies
- Catalytic Processes in Materials Science
- Metalloenzymes and iron-sulfur proteins
- Synthesis and Biological Evaluation
- Paraquat toxicity studies and treatments
- Porphyrin Metabolism and Disorders
- Organometallic Compounds Synthesis and Characterization
- Chemical Synthesis and Reactions
- Trypanosoma species research and implications
- Chromium effects and bioremediation
- Synthesis of Tetrazole Derivatives
Universidade Federal de Santa Catarina
1999-2024
State University of Norte Fluminense
2012-2021
Universidade Federal Rural do Rio de Janeiro
2021
Universidade Estadual da Zona Oeste
2021
Prefeitura Municipal de Campos dos Goytacazes
2005-2020
Rede de Química e Tecnologia
2015-2020
Fundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarina
2020
Universidade Federal do Rio de Janeiro
2001-2015
Texas A&M University
2010
Universidade Estadual de Campinas (UNICAMP)
2009
The coupling of oxetane (trimethylene oxide) and carbon dioxide catalyzed by VO(acac)2 in the presence an onium salt was studied. process found to be highly selective quantitative for production six-membered cyclic carbonate, trimethylene under very mild reaction conditions 60 °C 1.7 MPa. Other derivatives oxide were shown similarly selectively afford corresponding carbonates upon with CO2.
Due to their aerobic lifestyle, eukaryotic organisms have evolved different strategies overcome oxidative stress. The recruitment of some specific metalloenzymes such as superoxide dismutases (SODs) and catalases (CATs) is great importance for eliminating harmful reactive oxygen species (hydrogen peroxide anion). Using the ligand HPClNOL {1-[bis(pyridin-2-ylmethyl)amino]-3-chloropropan-2-ol}, we synthesized three coordination compounds containing iron(III), copper(II), manganese(II) ions,...
Toxoplasma gondii, the causative agent of toxoplasmosis, is an obligate intracellular protozoan that can infect a wide range vertebrate cells. Here, we describe cytotoxic effects dinuclear iron compound [Fe(HPCINOL)(SO4)]2-μ-oxo, in which HPCINOL ligand 1-(bis-pyridin-2-ylmethyl-amino)-3-chloropropan-2-ol, on T. gondii infecting LLC-MK2 host This was not toxic to cells at concentrations up 200 μM but very active against parasite, with 50% inhibitory concentration (IC50) 3.6 after 48 h...
Gliomas are the most common type of primary brain tumors, presenting high mortality and recurrence rates that highlight need for development more efficient therapies. In context, we investigated iron(iii) (FeL) copper(ii) (CuL) complexes containing tetradentate ligand 2-{[(3-chloro-2-hydroxy-propyl)-pyridin-2-ylmethyl-amino]-methyl}-phenol (L) as potential antimetastatic compounds in glioma cells. These were designed to act mimetics antioxidant metalloenzymes (catalases superoxide dismutase)...
Herein, we report reactivity studies of the mononuclear water-soluble complex [Mn(II)(HPClNOL)(η1-NO3)(η2-NO3)] 1, where HPClNOL = 1-(bis-pyridin-2-ylmethyl-amino)-3-chloropropan-2-ol, toward peroxides (H2O2 and tert-butylhydroperoxide). Both catalase (in aqueous solution) peroxidase CH3CN) activities 1 were evaluated using a range techniques including electronic absorption spectroscopy, volumetry (kinetic studies), pH monitoring during H2O2 disproportionation, electron paramagnetic...
The development of metallodrugs with antioxidant activities is importance as a way to protect organisms exposed stressful conditions. Although iron chemistry in the presence H2O2 usually associated pro-oxidant activity, mainly via Fenton reaction, we found that mononuclear compound [Fe(HPClNOL)Cl2]NO3 (1; C15H18Cl3FeN4O4, = 8.7751(3) Å, b 9.0778(4) c 24.3869(10) β 93.370(2)°, monoclinic, P21/c, Z 4), containing tripodal ligand 1-[bis(pyridin-2-ylmethyl)amino]-3-chloropropan-2-ol, decomposes...
A mixed-valence complex, [FeIIIFeIIL1(μ-OAc)2]BF4·H2O, where the ligand H2L1 = 2-{[[3-[((bis(pyridin-2-ylmethyl)amino)methyl)-2-hydroxy-5-methylbenzyl](pyridin-2-ylmethyl)amino]methyl]phenol}, has been studied with a range of techniques, and, possible, its properties have compared to those corresponding enzyme system purple acid phosphatase. The FeIIIFeII and FeIII2 oxidized species were spectroelectrochemically. temperature-dependent population S 3/2 spin states heterovalent system,...
Aging is a natural process characterized by several biological changes. In this context, oxidative stress appears as key factor that leads cells and organisms to severe dysfunctions diseases. To cope with reactive oxygen species oxidative-related damage, there has been increased use of superoxide dismutase (SOD)/catalase (CAT) biomimetic compounds. Recently, we have shown three metal-based compounds {[Fe(HPClNOL)Cl2]NO3, [Cu(HPClNOL)(CH3CN)](ClO4)2 Mn(HPClNOL)(Cl)2}, harboring in vitro SOD...
The synthesis, X-ray molecular structure, physico-chemical characterization and dual antioxidant activity (catalase superoxide dismutase) of a new polymeric mixed valence Mn(III)Mn(II) complex, containing the ligand H2BPClNOL (N-(2-hydroxybenzyl)-N-(2-pyridylmethyl)[(3-chlorophenyl)(2-hydroxy)] propylamine) is described. monomeric unit composed dinuclear Mn(II)Mn(III) moiety, [Mn(III)(μ-HBPClNOL)(μ-BPClNOL)Mn(II)(Cl)](ClO4)2H2O, 1, in which Mn ions are connected by two different bridging...
Intrinsic resistance of cancer cells is a major concern for the success chemotherapy, and this undesirable feature stimulates further research into design new compounds and/or alternative multiple drug chemotherapy protocols. In study, we investigated antitumoral potential coordination [Cu(HPClNOL)Cl]Cl (1), [Fe(HPClNOL)Cl2]NO3 (2) [Mn(HPClNOL)Cl2] (3). Using human, MCF-7 A549, murine melanoma, B16-F10, cell lines, determined cytotoxicity, DCFH oxidation, disruption mitochondrial membrane...