A5031066593- Public Health and Nutrition
- vaccines and immunoinformatics approaches
- Computational Drug Discovery Methods
- Medication Adherence and Compliance
- Medicinal Plant Research
- Asthma and respiratory diseases
- Diabetes Treatment and Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Tuberculosis Research and Epidemiology
- Artificial Intelligence in Healthcare
- Helicobacter pylori-related gastroenterology studies
- Cancer Genomics and Diagnostics
- Hepatitis C virus research
- Respiratory viral infections research
- Genetics, Bioinformatics, and Biomedical Research
- COVID-19 Clinical Research Studies
- Metabolism, Diabetes, and Cancer
- Bioinformatics and Genomic Networks
- Diabetes Management and Research
- Genetic Associations and Epidemiology
- Hepatitis B Virus Studies
- IL-33, ST2, and ILC Pathways
- Diabetes Management and Education
- Liver Disease Diagnosis and Treatment
- Biosimilars and Bioanalytical Methods
University of Muhammadiyah Mataram
2014-2024
Indonesian Institute of Sciences
2024
Indonesian Agency for Agricultural Research and Development
2024
National Research and Innovation Agency
2023-2024
Institute for Health Metrics and Evaluation
2024
University of Washington
2024
Universiti of Malaysia Sabah
2023
Taipei Medical University
2020-2022
Universitas Ahmad Dahlan
2014
<h2>Summary</h2><h3>Background</h3> Disorders affecting the nervous system are diverse and include neurodevelopmental disorders, late-life neurodegeneration, newly emergent conditions, such as cognitive impairment following COVID-19. Previous publications from Global Burden of Disease, Injuries, Risk Factor Study estimated burden 15 neurological conditions in 2015 2016, but these analyses did not defined by International Classification Diseases (ICD)-11, or a subset cases congenital,...
<h2>Summary</h2><h3>Background</h3> This study aims to estimate the burden, trends, forecasts, and disparities of early musculoskeletal (MSK) disorders among individuals ages 15 39 years. <h3>Methods</h3> The global prevalence, years lived with disabilities (YLDs), disability-adjusted life (DALYs), projection, inequality were estimated for MSK diseases, including rheumatoid arthritis (RA), osteoarthritis (OA), low back pain (LBP), neck (NP), gout, other diseases (OMSKDs). <h3>Findings</h3>...
Asthma is a common and heterogeneous disease characterized by chronic airway inflammation. Currently, the two main types of asthma medicines are inhaled corticosteroids long-acting β2-adrenoceptor agonists (LABAs). In addition, biological drugs provide another therapeutic option, especially for patients with severe asthma. However, these were less effective in preventing exacerbation, other drug options still limited. Herein, we extracted asthma-associated single nucleotide polymorphisms...
Objective: This study investigated the anti-inflammatory potential of metformin as a therapeutic agent in an experimental hemorrhoid model using Sprague-Dawley rats. Methods: Rats were assigned to six groups: normal control, negative control (hemorrhoid-induced without treatment), positive and treated with aspirin), three metformin-treated groups receiving 3 mg/kg, 9 15 mg/kg body weight doses. Metformin's effects assessed through macroscopic observation, qPCR analysis IL-6, TNF-α, IL-10,...
Atopic Dermatitis (AD) is a chronic and relapsing skin disease. The medications for treating AD are still limited, most of them topical corticosteroid creams or antibiotics. current study attempted to discover potential treatments by integrating gene network genomic analytic approaches. Herein, the Single Nucleotide Polymorphism (SNPs) associated with were extracted from GWAS catalog. We identified 70 AD-associated loci, then 94 risk genes found extending proximal SNPs based on
Multiple sclerosis (MS) is a chronic autoimmune disease in the central nervous system (CNS) marked by inflammation, demyelination, and axonal loss. Currently available MS medication limited, thereby calling for strategy to accelerate new drug discovery. One of strategies discover drugs utilize old indications, an approach known as repurposing. Herein, we first identified 421 MS-associated SNPs from Genome-Wide Association Study (GWAS) catalog (p-value < 5 × 10-8), total 427 risk genes...
One of the main challenges in personalized medicine is to establish and apply a large number variants from genomic databases into clinical diagnostics further facilitate genome-driven drug repurposing. By utilizing biological chronic hepatitis B infection (CHB) risk genes, our study proposed systematic approach use drive repurposing for CHB. The were retrieved Genome-Wide Association Study (GWAS) Phenome-Wide (PheWAS) databases. Then, CHB genes crucial progression prioritized based on...
Childhood asthma represents a heterogeneous disease resulting from the interaction between genetic factors and environmental exposures. Currently, finding reliable biomarkers is necessary for clinical management of childhood asthma. However, only few are being used in practice pediatric population. In long run, new children required would help direct therapy approaches. This study aims to identify potential using genetic-driven approach. Herein, asthma-associated Single Nucleotide...
Hepatocellular carcinoma (HCC) often develops from chronic hepatitis B (CHB) through replication of virus (HBV) infection. Calcium (Ca2+) signaling plays an essential role in HBV replication. Store-operated calcium (SOC) channels are a major pathway Ca2+ entry into non-excitable cells such as immune and cancer cells. The basic components SOC include the STIM1 ORAI1 genes. However, roles HBV-mediated HCC still unclear. Thus, long-term follow-up cohort was carried out this study. This study...
Objective: Examines the effects of counseling and short messages service (SMS) as a reminder motivation toward medication adherence improvement controlled HbA1c levels type 2 diabetes mellitus (T2DM) patients.Methods: This study used quasi-experimental method with prospective data retrieval. The subjects this were 40 patients outpatient T2DM in internal disease polyclinic West Nusa Tenggara Hospital, Indonesia. Patients who fulfilled inclusion criteria divided into two groups: control group...
A major challenge in translating genomic variants of Tuberculosis (TB) into clinical implementation is to integrate the disease-associated and facilitate drug discovery through concept genomic-driven repurposing. Here, we utilized two established databases, namely a Genome-Wide Association Study (GWAS) Phenome-Wide (PheWAS) identify associated with TB disease further utilize them for drug-targeted genes. We evaluated 3.425 which overlapped 200 TB-associated To prioritize biological risk...
Abstract Background Studies have attributed 50% of infertility cases to male infertility, 15% which is caused by idiopathic genetic factors. Currently, no specific biomarkers been revealed for infertility. Furthermore, research on factors causing still limited. As with other multifactorial disorders, numerous risk loci identified genome-wide association studies (GWAS), although their clinical significance remains uncertain. Therefore, we utilized an integrative bioinformatics-based approach...
Poor adherence and a lack of understanding medication instructions for oral antidiabetic use are key factors that inhibit the control glycemic levels. The aforementioned situation needs intervention to improve therapy. This study was conducted with quasi-experimental design prospective data collection. subjects this were 50 outpatients type 2 diabetes melitus (T2DM) who had received medicine therapy at least six months prior measurement. patients classified into two groups-the group group....
Osteoporosis is characterized by decreased bone mineral density and increased risk of fracture. Raloxifene one the treatments osteoporosis. However, responses were variable among patients. Previous studies revealed that genetic variants are involved in regulation treatment outcomes. To date, evaluate influence genes across all genome on raloxifene response still limited. In this study, a total 41 postmenopausal osteoporosis patients under regular included. Gene-based analysis using MAGMA was...
According to the National Comprehensive Cancer Network and American Society of Clinical Oncology, standard treatment for pancreatic cancer (PC) is gemcitabine fluorouracil. Other chemotherapeutic agents have been widely combined. However, drug resistance remains a huge challenge, leading ineffectiveness therapy. Therefore, we are trying discover new treatments PC by utilizing genomic information identify PC-associated genes as well target repurposing. Genomic from public database, cBio...
Chickenpox (varicella) is caused by infection with the varicella-zoster virus (VZV), a neurotropic alpha herpes double-stranded DNA genome. can cause life-threatening complications, including subsequent bacterial infections, central nervous system symptoms, and even death without any risk factors. Few studies have been reported to investigate genetic susceptibility implicated in chickenpox. Herein, our study identified global variants that potentially contributed chickenpox utilizing...
The diabetic patient’s quality of life and adherence should be a concerned by health care providers. This study aimed to explore the medication into account. We recruited 88 subjects in cross-sectional design. research were out-patients with type 2 diabetes mellitus private hospitals Yogyakarta City who had taken single or combination oral anti insulin at least six months prior measurement. Patients classified three groups (monotherapy, therapy, oral-insulin group). domains physical...
An autoimmune disorder is an abnormality that causes a disease. It caused by weakened immune system. One of the diseases Sjogren's syndrome, which affects salivary and lacrimal glands dry mouth, eyes, skin. syndrome influences humans every age, with symptoms occurring at age 45–55 years rarely in children. factors causing genetic disorders. To identify genes can influence this study, we used several databases, including GWAS Catalog, HaploReg Version 4.1, GTEX portal, Ensembl, particularly...
Drug-resistant tuberculosis (TB), which results mainly from the selection of naturally resistant strains Mycobacterium (MTB) due to mismanaged treatment, poses a severe challenge global control TB. Therefore, screening novel and unique drug targets against this pathogen is urgently needed. The metabolic pathways Homo sapiens MTB were compared using Kyoto Encyclopedia Genes Genomes tool, further, proteins that are involved in subtracted proceeded protein-protein interaction network analysis,...
Abstract Diabetic foot ulcers (DFUs) are a common complication of diabetes and can lead to severe disability even amputation. Despite advances in treatment, there is currently no cure for DFUs available drugs treatment limited. This study aimed identify new candidate repurpose existing treat based on transcriptomics analysis. A total 31 differentially expressed genes (DEGs) were identified used prioritize the biological risk DFUs. Further investigation using database DGIdb revealed 12...
Hemorrhoids are a prevalent medical condition that necessitates effective treatment options. The current options for consist of oral medications, topical applications, or surgery, yet scarcity highly drugs still exists. Genetic markers provide promising avenues investigating the hemorrhoids, as they may reveal intricate biological mechanisms and targeted drug therapies, ultimately enhancing more precise tailored to patient. This study aims identify new candidates treating hemorrhoids through...