A5026063627- Pancreatic and Hepatic Oncology Research
- Sarcoma Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Epigenetics and DNA Methylation
- Soft tissue tumor case studies
- Renal cell carcinoma treatment
- Colorectal and Anal Carcinomas
- Nuclear Structure and Function
- Viral-associated cancers and disorders
- Cancer Cells and Metastasis
- Renal and related cancers
- Gastrointestinal disorders and treatments
- Urologic and reproductive health conditions
- Antifungal resistance and susceptibility
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Gastrointestinal Tumor Research and Treatment
- Lymphoma Diagnosis and Treatment
- Magnesium in Health and Disease
- Esophageal and GI Pathology
- Cardiac tumors and thrombi
- Neuroendocrine Tumor Research Advances
- Tuberous Sclerosis Complex Research
- Cervical Cancer and HPV Research
- IgG4-Related and Inflammatory Diseases
University of Michigan
2019-2025
UPMC Health System
2022
Michigan Center for Translational Pathology
2021
Stony Brook University
2016
Context.— Plexiform fibromyxomas are uncommon gastrointestinal neoplasms that have histologic and molecular features overlap with other mesenchymal tumors present a diagnostic challenge for surgical pathologists. Objective.— To provide review of the clinicopathologic, morphologic, immunohistochemical, plexiform fibromyxomas, brief discussion key aid in differential diagnosis. Data Sources.— Analysis pertinent literature (PubMed) clinical practice experience based on institutional...
Inactivating mutations of KDM6A, a histone demethylase, were frequently found in pancreatic ductal adenocarcinoma (PDAC). We investigated the role KDM6A (lysine demethylase 6A) PDAC development.We performed tissue microarray analysis protein levels. used human cell lines for knockout and knockdown experiments. bromouridine sequencing to elucidate effects loss on global transcription. studies with Ptf1aCre; LSL-KrasG12D; Trp53R172H/+; Kdm6afl/fl or fl/Y, orthotopic xenograft mice investigate...
Aims Distinguishing true oesophageal Candida infections from oral contaminants is a common diagnostic issue. Historically, histological features believed to indicate infection included epithelial invasion by pseudohyphae and intraepithelial neutrophils. Whether or not these correlate with endoscopic lesions, symptoms response therapy has never been tested in large cohort. The aim of this study was determine whether specific clinical findings when found biopsies. Methods results We reviewed...
Ewing sarcoma (ES) is an uncommon mesenchymal neoplasm that typically develops as a bone mass, although up to 30% arise in extraskeletal sites. ES of the gastrointestinal (GI) and hepatobiliary tract rare may be misdiagnosed other, more common neoplasms occur these However, correct classification important for timely clinical management prognostication. We reviewed our experience GI order further highlight clinicopathologic features document potential misdiagnosis this setting. The archives...
e14091 Background: In order to maintain their malignant phenotype, neoplastic cells must neutralize most of tumor suppressor (TSP) and growth regulatory (GRP) proteins. CRM1, also called exportin 1, mediates the nuclear export majority TSP/GRP, leading inactivation. Blockade CRM1 with SINE induces cytotoxicity in cells, but only reversible cell cycle arrest normal cells. We report on potential for treatment molecular subtypes CRC. Methods: KPT-127 is a moderate potency, small-molecule...
Cellular dermatofibromas (CDFs) and dermatofibrosarcoma protuberans (DFSP) can be challenging to differentiate from one another. Morphologically, both entities commonly extend into the subcutis, exhibit high cellularity with limited cytologic atypia have a mixed fascicular-to-storiform growth pattern. We sought evaluate significance of fat necrosis an associated lymphocytic infiltrate as histopathologic clue for distinguishing CDFs DFSP.We identified cases in our pathology database primary...
Abstract Despite the poor long-term survival of patients with pancreatic ductal adenocarcinoma (PDA), there are significant probabilities in subgroups that cannot be predicted by surgical, pathological, and clinical features, including stage, surgical margins perineural invasion. Only last year, more than a handful papers reported advanced genomic analyses on multiple components tumors to dissect molecular heterogeneities may provide better understanding gene expression signatures predict...
Abstract Introduction/Objective Papillary squamous cell carcinoma (PSCC) is a rare cervical neoplasm composed of papillae lined by atypical squamous/transitional cells without koilocytosis. It unclear whether PSCC related to human papillomavirus (HPV) infection, though cases were reportedly associated with HPV type 16. thought be more common in postmenopausal women. Some authors have suggested that may understaged due the prominent exophytic nature superficial aspect and relatively deep...
Yamada, Takayuki; Kalaria, Arjun L.; Schechter, Shula; Bender, Filitsa H. Author Information