A5090130477- Thyroid Disorders and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Pituitary Gland Disorders and Treatments
- Cancer Immunotherapy and Biomarkers
- Cytokine Signaling Pathways and Interactions
- Growth Hormone and Insulin-like Growth Factors
- Diabetes Treatment and Management
- Adrenal Hormones and Disorders
- Neuroblastoma Research and Treatments
- interferon and immune responses
- Diabetes Management and Research
- Vitamin D Research Studies
- Pancreatic function and diabetes
- BRCA gene mutations in cancer
- Nutritional Studies and Diet
- Hypothalamic control of reproductive hormones
- Metabolism, Diabetes, and Cancer
- Peripheral Neuropathies and Disorders
- Genetic Syndromes and Imprinting
- Natural product bioactivities and synthesis
- Atherosclerosis and Cardiovascular Diseases
- Glioma Diagnosis and Treatment
- Cancer survivorship and care
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Muscle and Compartmental Disorders
University of Chieti-Pescara
2016-2025
Azienda USL di Pescara
2022-2024
Johns Hopkins University
2016-2021
Ibero American University
2020
Johns Hopkins Medicine
2016-2019
Reactive oxygen species (ROS) have been extensively studied in the induction of inflammation and tissue damage, especially as it relates to aging. In more recent years, ROS implicated pathogenesis autoimmune diseases. Here, accumulation leads apoptosis autoantigen structural changes that result novel specificities. not only initiation response but also its amplification spreading epitopes, through unmasking cryptic determinants. This review will examine contribution four organ specific...
Background/Objectives: Semaglutide is the unique once-daily oral glucagon-like receptor agonist presently available. Aims of this study were to describe clinical characteristics patients with type 2 diabetes (T2D) initiating semaglutide, assess its effects on glycemic control, body weight (BW) and tolerability in routine practice. Methods: Electronic medical records from two Italian clinics evaluated. Mean glycated hemoglobin (HbA1c) BW assessed adults T2D before 6 months after semaglutide...
Summary Programmed cell death protein 1/programmed ligand 1 (PD-1/PD-L1) and cytotoxic T-lymphocyte antigen 4/B7 (CTLA-4/B7) pathways are key regulators in T-cell activation tolerance. Nivolumab, pembrolizumab (PD-1 inhibitors), atezolizumab (PD-L1 inhibitor) ipilimumab (CTLA-4 monoclonal antibodies approved for treatment of several advanced cancers. Immune checkpoint inhibitors (ICIs)-related hypophysitis is described more frequently patients treated with anti-CTLA-4; however, recent...
Abstract Context The risk stratification of patients with differentiated thyroid cancer (DTC) is crucial in clinical decision making. most widely accepted method to assess recurrent/persistent disease described the 2015 American Thyroid Association (ATA) guidelines. However, recent research has focused on inclusion novel features or questioned relevance currently included features. Objective To develop a comprehensive data-driven model predict persistent/recurrent that can capture all...
Abstract Context The risk of recurrence papillary thyroid carcinoma smaller than 1 cm (microPTC) is low. Predictors disease persistence in microPTC are still unclear. Objective To compare the clinical and pathological characteristics microPTCs with macrocarcinomas (PTC > cm), identifying predictors biochemical structural incomplete response one year after initial treatment microPTC. Methods We included patients consecutively enrolled Italian Thyroid Cancer Observatory (NCT04031339),...
Background: Neonatal thyrotropin (TSH) on dried blood spot (DBS), the most common screening strategy for primary congenital hypothyroidism (CH), is influenced by numerous factors that may hinder a true CH diagnosis. A second test can thus be performed to clarify initial findings, although its application varies among programs. Objectives: The aim of this study was evaluate effect maternal and neonatal TSH levels offer practical recommendations. Methods: We retrospectively analyzed data...
Quercetin is the most abundant flavonoid present in fruits and vegetables. For its antiproliferative, antiviral, anti-inflammatory antioxidants activities, it an active ingredient of several herbal remedies available as a nutraceutical. Experimental studies performed vitro have demonstrated that quercetin inhibits growth function normal thyroid cells may act disruptor. These effects also been confirmed vivo using rodent models. Some reported ability to interfere with metabolism hormones,...
Background: Cytotoxic T-lymphocyte associated protein 4 (CTLA-4) is a negative regulator of immune responses that suppresses the activity effector T cells and contributes to maintenance self tolerance.When blocked therapeutically, CTLA-4 leads an overall activation has been exploited for cancer control, control however with variety immune-related side effects such as autoimmune thyroiditis.To investigate mechanism(s) underlying this form thyroiditis, we used NOD-H2 h4 mouse, model develops...
Biotinidase deficiency (BD) is an autosomal recessive inherited disorder in which the enzyme biotinidase totally or partially defective and vitamin biotin not recycled. BD meets major criteria for a population screening program. Newborn bloodspot (NBS) allows early diagnosis of BD, thus preventing high morbidity mortality associated with untreated disease. Both profound partial variant can be detected by NBS test, serum activity and/or mutational analysis are required definitive diagnosis....
Aims This study aims to evaluate the effectiveness and tolerability of once-weekly glucagon-like peptide receptor agonists (OW GLP-1RAs) assess clinical benefits switching from one GLP-1RA another (switchers) in a routine setting. Materials Methods is retrospective, real-world cohort study, based on electronic medical records utilized Italian diabetes clinic. Estimated mean changes HbA1c body weight after 6 12 months first prescription long-acting GLP1-RA were evaluated using longitudinal...
The pathogenesis of thyroiditis caused by immune-checkpoint inhibitors (ICIs) such as antiprogrammed death receptor-1 (PD-1) and anticytotoxic T lymphocyte antigen-4 (CTLA-4) is incompletely understood. To gain mechanistic insights, we developed a mouse model ICI-related assessed the clinical, hormonal, cytokine profiles.
MYMD-1 is a synthetic derivative of tobacco alkaloids, compounds that possess immunoregulatory properties and have been linked to the epidemiological observation smoking reduces odds developing thyroid Abs hypothyroidism. To assess effect mechanism(s) action MYMD-1, we chose NOD.H-2h4 mouse model spontaneous thyroiditis. We began in vitro using T cells isolated from spleens found suppressed TNF-α production by CD4+ dose-dependent manner. then treated 58 mice for 12 wk with either...
Papillary thyroid cancer (PTC) often co-occurs with Hashimoto's thyroiditis, an association that has long been reported in clinical studies yet remains controversial. Some studies, fact, have suggested a protective effect of thyroiditis while others not. We generated mouse model where PTC and develop predictable manner, combining the oncogenic drive BRAFv600E mutation (inducible by tamoxifen) to susceptibility NOD.H2h4 strain iodine). A total 113 NOD.H2h4_TPO-CRE-ER_BRAFV600E mice (50...
Abstract Context The utility of thyroglobulin (Tg) in the follow-up patients with differentiated thyroid cancer has been well-documented. Although third-generation immunoassays have improved accuracy, limitations persist (interfering anti-Tg antibodies and measurement variability). Evolving treatment strategies require a reevaluation Tg thresholds for optimal patient management. Objective To assess performance serum testing 2 populations: receiving total thyroidectomy radioiodine remnant...