A5045446926- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Gallbladder and Bile Duct Disorders
- Gastrointestinal disorders and treatments
- Dermatological and COVID-19 studies
- Esophageal and GI Pathology
- Pediatric Hepatobiliary Diseases and Treatments
- Colorectal Cancer Screening and Detection
- Abdominal Surgery and Complications
- Biliary and Gastrointestinal Fistulas
- Gastrointestinal Bleeding Diagnosis and Treatment
- Appendicitis Diagnosis and Management
- COVID-19 Clinical Research Studies
- Genetic factors in colorectal cancer
- Abdominal vascular conditions and treatments
- Hernia repair and management
- Abdominal Trauma and Injuries
- Foreign Body Medical Cases
- Potassium and Related Disorders
- Inflammatory Myopathies and Dermatomyositis
- Head and Neck Surgical Oncology
- Helicobacter pylori-related gastroenterology studies
- Celiac Disease Research and Management
- Gastrointestinal Tumor Research and Treatment
- Muscle and Compartmental Disorders
Copenhagen University Hospital
2013-2024
Hvidovre Hospital
2012-2023
Amager Hospital
2022-2023
Pancreas Centre (Canada)
2022
University of Michigan
2020
University of Kansas
2020
University of Copenhagen
1985-2019
Herzog August Library
2006
American Society of Transplantation
2001
Goethe University Frankfurt
1995
Background: Several studies have suggested that clinical indices of disease activity in inflammatory bowel (IBD) do not adequately reflect the degree inflammation most such patients. Faecal excretion indium-111-labelled neutrophilic granulocytes has been as gold standard activity, but its complexity and high cost exposure patients to ionizing irradiation limited use this technique. The aim study was investigate correlation between faecal granulocyte marker protein calprotectin 111In-labelled...
Background. The definition of a "difficult" cannulation varies considerably in reports endoscopic retrograde cholangiopancreatography (ERCP). Aims. To define difficult cannulation, which translates into higher risk post-ERCP pancreatitis. Patients and methods. Prospective consecutive recording 907 cannulations Scandinavian centers done by experienced endoscopists. Inclusion: indication for biliary access patients with intact papilla. Exclusion: acute non-biliary chronic pancreatitis at time...
Hemospray TM (TC-325) is a novel hemostatic agent licensed for use in nonvariceal upper gastrointestinal bleeding (NVUGIB) Europe.We present the operating characteristics and performance of TC-325 largest registry to date patients presenting with NVUGIB everyday clinical practice.Prospective anonymized data device outcomes were collected from 10 European centers using multicentre SEAL survey (Survey Evaluate Application Luminal tract). was used as monotherapy or second-line therapy...
Objective In treating pancreatic walled-off necrosis (WON), lumen-apposing metal stents (LAMS) have not proven superior to the traditional double pigtail technique (DPT). Among patients with large WON (>15 cm) and their associated substantial risk of treatment failure, increased drainage capacity a novel 20-mm LAMS might improve clinical outcomes. Hence, we conducted study comparing DPT in WON. Design A single-centre, open-label, randomised, controlled superiority trial using an...
Abstract Background Pancreatic duct disruption is common and associated with high morbidity in cases of acute necrotizing pancreatitis (ANP). In this study, we tested the feasibility safety prophylactic pancreatic stenting (PPDS) ANP compared PPDS conservative treatment. Methods We prospectively enrolled patients (aged 18 – 75 years) diagnosed between February 2011 July 2015. These were randomized to receive or treatment at two tertiary centers. was performed as soon possible after...
Endoscopic transmural drainage and necrosectomy (ETDN) is a promising alternative to percutaneous surgical intervention in the treatment of walled-off pancreatic peripancreatic necroses (WONs). We assessed outcome safety profile ETDN single-center patient cohort.In November 2005, for WON was introduced our tertiary referral center. During 6-year period (Nov 2005-Nov 2011), we retrospectively collected data on all patients who underwent ETDN.Eighty-one were treated with (median age 54, 52...
Acute pancreatitis with walled-off necrosis (WON) is associated considerable morbidity and mortality. Previous studies have evaluated outcomes in WON collections of limited size, while data about large long-term follow-up are lacking. We aimed to report our experience managing WON.Between 2010 2020, consecutive patients (>15 cm) were identified from a prospectively maintained database. Patients chronic or an index intervention 90 days more the debut symptoms excluded. registered clinical...
Cameron lesions are linear gastric ulcers or erosions on the mucosal folds at diaphragmatic impression in patients with a large hiatal hernia. The associated occult bleeding and development of chronic iron deficiency anaemia, but often overlooked during routine endoscopy. We present two known hernias who repeated endoscopic examinations had not been able to identify source bleeding. In both cases, typical were found either by repeat gastroscopy capsule Treatment high-dose proton pump...
Cannulation of the papilla vateri represents an enigmatic first step in endoscopic retrograde cholangiopancreaticography (ERCP). In light falling numbers (diagnostic) ERCP and novel techniques, e.g. short-wire system, we were interested approach novice experienced endoscopist are taking; especially, what makes a difficult to cannulate how this. We devised structured online questionnaire, sent all endoscopists registered with SADE, Scandinavian Association for Digestive Endoscopy. A total 141...
Background and aims Several studies have shown improved short‐term outcome with endoscopic transmural drainage necrosectomy for the treatment of walled‐off pancreatic necrosis. However, knowledge on long‐term prognosis after such is limited. The aim present study was to evaluate outcomes in patients endoscopically treated necrosectomy. Methods We retrospectively follow up 125 necrosis 2010–2017. All received plastic pigtail stents nasocystic catheter. Additional external performed 41...
This study aimed to evaluate the influence of fungal infection and antifungal treatment on outcome in patients with walled-off pancreatic necrosis (WON).A retrospective description infections a cohort consecutive undergoing endoscopic, transmural drainage necrosectomy for WON, treated tertiary referral center was reviewed.Between 2005 2013, WON documented 57 (46%) 123 patients. The most common isolates at first positive culture were Candida albicans (55%) glabrata (20%). Thirty-nine (70%)...
Chronic pancreatitis (CP) is thought to present the end stage of a continuous disease process evolving from acute (AP), over recurrent AP, early and end-stage CP. Due irreversible nature CP, detection prevention key. Prospective assessment based on advanced imaging modalities as well biochemical markers inflammation, fibrosis oxidative stress may provide better understanding underlying pathological processes help identify novel biomarkers with ultimate goal diagnosis, intervention...
Background and AimsEUS-guided drainage and, if required, endoscopic necrosectomy (EN) has become the criterion standard for treatment of pancreatic walled-off necrosis (WON). A dedicated powered debridement system, EndoRotor (Interscope Inc, Northbridge, Mass, USA), been introduced as an alternative to snare necrosectomy. This study evaluates novel catheter, NecroMax 6.0 Whitinsville, EN in patients with WON.MethodsThis single-center retrospective case series included consecutive WON treated...
Infected walled-off necrosis is a potentially life-threatening complication of necrotizing pancreatitis. While some patients can be treated by drainage alone, many also need evacuation the infected debris. Central necroses in relation to pancreatic bed are easily reached via an endoscopic transluminal approach, whereas that involve paracolic gutters and pelvis most efficiently percutaneous approach. Large complex may combination two methods.Transluminal followed simultaneous modified...
Background and objective: Gallstones are highly prevalent, more than 9000 cholecystectomies performed annually in Denmark. The aim of this guideline was to improve the clinical course patients with gallstone disease including a subgroup high-risk patients. Outcomes included reduction complications, readmissions, need for additional interventions uncomplicated disease, acute cholecystitis, common bile duct stones (CBDS). Methods: An interdisciplinary group clinicians developed according GRADE...
Autoimmune pancreatitis (AIP) is a rare inflammatory disease. AIP has characteristic histology, serology and imaging findings. Two types of exist, type 1, which part the systemic immunoglobulin G4-related disease, 2, only localized to pancreas. Patients with 1 are predominantly older men, have involvement other organs more often experience relapse than patients 2. Both respond well steroid treatment. The most important differential diagnose pancreatic cancer.
Faecal plasma protein loss was studied in 38 healthy adults. Using crossed immuno-electrophoresis and single radial immunodiffusion the most frequently found proteins were α1-antitrypsin, IgA, α1-antichymotrypsin (found 97, 92, 84% of subjects), prealbumin IgM (both 55%). The major proteins, albumin IgG, 37 13% subjects, respectively, trace amounts only. α2-macroglobulin could not be detected. There no relation between presence faeces their concentration. When added to faeces,...