A5019592253- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Gallbladder and Bile Duct Disorders
- Gastrointestinal disorders and treatments
- Liver Disease Diagnosis and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Abdominal Surgery and Complications
- Dermatological and COVID-19 studies
- Esophageal and GI Pathology
- Gastroesophageal reflux and treatments
- Abdominal vascular conditions and treatments
- Appendicitis Diagnosis and Management
- COVID-19 Clinical Research Studies
- Biliary and Gastrointestinal Fistulas
- Bariatric Surgery and Outcomes
- Gastrointestinal motility and disorders
- Lipid metabolism and disorders
- Neuroendocrine Tumor Research Advances
- Apelin-related biomedical research
- Intestinal Malrotation and Obstruction Disorders
- Gastric Cancer Management and Outcomes
- Electrolyte and hormonal disorders
- Hemodynamic Monitoring and Therapy
- Blood Pressure and Hypertension Studies
- Paraoxonase enzyme and polymorphisms
Hvidovre Hospital
2016-2025
Copenhagen University Hospital
2016-2025
University of Copenhagen
2013-2025
Amager Hospital
2022-2025
Pancreas Centre (Canada)
2022
Bispebjerg Hospital
2009-2021
Aalborg University Hospital
2021
Odense University Hospital
2021
Rigshospitalet
2009
Frederiksberg Hospital
2007
We aimed at synchronously examining the early time course of 4 proinflammatory cytokines as predictive factors for development organ failure in patients with acute pancreatitis (AP).Interleukin (IL) 6, IL-8, IL-18, and tumor necrosis factor α were measured on admission days 1, 2, 14 60 admitted first attack AP. The prediction single-organ multiorgan from cytokine profiles was evaluated by receiver operating characteristic analyses.Interleukin 6 IL-8 levels significantly higher who developed...
Objective In treating pancreatic walled-off necrosis (WON), lumen-apposing metal stents (LAMS) have not proven superior to the traditional double pigtail technique (DPT). Among patients with large WON (>15 cm) and their associated substantial risk of treatment failure, increased drainage capacity a novel 20-mm LAMS might improve clinical outcomes. Hence, we conducted study comparing DPT in WON. Design A single-centre, open-label, randomised, controlled superiority trial using an...
OBJECTIVES: Chronic pancreatitis (CP) is characterized by several disease-related complications and multiple etiological risk factors. Past studies of associations between factors have mostly been limited to single or highly focused on etiologies. Using an objective data-driven approach (cluster analysis), we complication clusters their with in a large cohort patients CP. METHODS: This was multicenter, cross-sectional study including 1,071 CP from the Scandinavian Baltic countries....
INTRODUCTION: Opioids used to manage severe pain in acute pancreatitis (AP) might exacerbate the disease through effects on gastrointestinal and immune functions. Methylnaltrexone, a peripherally acting µ-opioid receptor antagonist, may counteract these without changing analgesia. METHODS: This double-blind, randomized, placebo-controlled trial included adult patients with AP systemic inflammatory response syndrome at 4 Danish centers. Patients were randomized receive 5 days of continuous...
Dysmotility is common in acute pancreatitis (AP) and may be evaluated using radiopaque markers imaging. We present a simple CT-based approach, which was employed hospitalized patients with AP. This secondary analysis of randomized, controlled trial conducted at four Danish centers. Patients admitted AP systemic inflammatory response syndrome were randomized to receive 5 days intravenous methylnaltrexone or placebo (lactated ringer) added standard management. Self-reported stool frequency...
Objectives: Chronic pancreatitis (CP) is a multifaceted disease associated with several risk factors and complex clinical presentation. We established the Scandinavian Baltic Pancreatic Club (SBPC) Database to characterise study natural history of CP in Northern European cohort. Here, we describe design database characteristics cohort.Methods: Nine centres from six different countries Scandinavian-Baltic region joined database. Patients definitive or probable (M-ANNHEIM diagnostic criteria)...
Abstract Background Updated population‐based estimates on incidence and prevalence of chronic pancreatitis are scarce. Methods We used nationwide healthcare registries to identify all Danish patients diagnosed with computed crude standardised rates in 1994–2018. Incidence were evaluated relation age gender, aetiology (alcoholic vs. non‐alcoholic) smoking alcohol consumption the general population. Results The mean rate during study period was 12.6 per 100,000 person years for total...
Objectives. We tested the hypothesis that 25-hydroxyvitamin D3 (25OHD) changes during acute inflammation in humans. Methods. Patients with first episode of pancreatitis were included. Blood samples acquired on admission and days 1, 2, 14. Results. In total, 73 patients (35 males, median age 59) entered study. On admission, distribution 25-OHD levels was as follows: severely deficient (<13 nmol/L) 23%; (13–25 20%; insufficient (26–50 40%; normal (<50 17%. There a significant fall linear trend...
Objective. Spontaneous bacterial peritonitis is a common infection in cirrhosis, associated with high mortality. Third-generation cephalosporins are recommended as first-line treatment. The aim was to evaluate the epidemiology of microbiological ascitic fluid findings and antimicrobial resistance Denmark. Material Methods. All patients cirrhosis positive culture, at three university hospitals Copenhagen area during 7-year period, were retrospectively evaluated. Patients apparent secondary...
Diabetes mellitus is a common complication of chronic pancreatitis. It traditionally considered to develop as consequence beta cell loss, but there might be additional factors. Recent studies have highlighted the importance type 2 diabetes-related risk factors in this context and population-based show increased diabetes following acute The aim study was explore multiple for patients with pancreatitis.We conducted multicentre, cross-sectional definitive pancreatitis according M-ANNHEIM...
There is scarce information about risk factors for exocrine pancreas insufficiency (EPI) in chronic pancreatitis (CP), and how it associates with other complications. The aim of the present study was to examine EPI associations procedures CP related complications a large, Northern European cohort. We retrieved cross-sectional data on demographics, status EPI, aetiological CP, as well surgical endoscopic treatment from Scandinavian Baltic Pancreatic Club Database. Associations were assessed...
In this study, we compared continuous cardiac output (CO) obtained from the femoral arterial pressure by simulation of an aortic input impedance model [model-simulated (MCO)] to thermodilution (TDCO) determined bolus injection during liver transplantation. Both variables were measured in 39 adult patients (13 females) every 10th minute transplant surgery. Paired measurements 4 phases surgery-dissection, anhepatic phase, early reperfusion (the first 15 minutes after reperfusion), and late...
Abdominal pain is the primary symptom of chronic pancreatitis (CP), but difficult to assess, and objective methods for assessment are lacking. The characterization sensory component as a surrogate nociception can be achieved by testing using standardized stimuli. Herein, we describe rationale development an international consortium better understand characterize CP pain.A collaboration was initially formed between University Aalborg, Johns Hopkins University, Pittsburgh. This group refined...
Endoscopic transmural drainage and necrosectomy (ETDN) is a promising alternative to percutaneous surgical intervention in the treatment of walled-off pancreatic peripancreatic necroses (WONs). We assessed outcome safety profile ETDN single-center patient cohort.In November 2005, for WON was introduced our tertiary referral center. During 6-year period (Nov 2005-Nov 2011), we retrospectively collected data on all patients who underwent ETDN.Eighty-one were treated with (median age 54, 52...
Pain is the primary symptom of chronic pancreatitis (CP) and associates with a number patient disease characteristics. However, complex interrelations these parameters are incompletely understood, pain treatment remains unsatisfactory in large proportion patients. The aim this study to investigate multiple risk factors population CP patients, special emphasis on patients' patterns smoking alcohol use.This was multicenter, cross-sectional including 1384 patients CP. Patient demographics...
Abstract Objectives Pancreatic exocrine insufficiency (PEI) is a common complication in patients with chronic pancreatitis (CP), leading to increased morbidity and mortality if not treated adequately. enzyme replacement therapy|pancreas therapy (PERT) the cornerstone treatment of PEI. In present study, we use data from Scandinavian Baltic Club database examine adherence PERT according United European Gastroenterology evidence‐based guidelines CP. Patients methods definitive or probable CP...
Chronic pancreatitis (CP) is the end-stage of continuous inflammation and fibrosis in pancreas evolving from acute- to recurrent acute-, early, and, finally, CP. Currently, prevention only way reduce disease burden. In this setting, early detection great importance. Due anatomy risks associated with direct sampling pancreatic tissue, most our information on human arises circulating biomarkers thought be involved pathophysiology or injury. The present review provides status development progression