A5100637444- Gallbladder and Bile Duct Disorders
- Pancreatic and Hepatic Oncology Research
- Pediatric Hepatobiliary Diseases and Treatments
- Esophageal and GI Pathology
- Pancreatitis Pathology and Treatment
- Microbial Natural Products and Biosynthesis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastrointestinal disorders and treatments
- Fungal Biology and Applications
- Cancer Treatment and Pharmacology
- Biliary and Gastrointestinal Fistulas
- Neuroblastoma Research and Treatments
- Neuroendocrine Tumor Research Advances
- Chemotherapy-related skin toxicity
- Plant Pathogens and Fungal Diseases
- Microbial Metabolism and Applications
- Cancer Research and Treatments
- Multiple Myeloma Research and Treatments
- Toxin Mechanisms and Immunotoxins
- Antibiotics Pharmacokinetics and Efficacy
- Silymarin and Mushroom Poisoning
- Comparative Animal Anatomy Studies
- Bariatric Surgery and Outcomes
- Neurobiology and Insect Physiology Research
- Bone and Dental Protein Studies
Juntendo University
2019-2025
Pancreas Centre (Canada)
2022
East Asia School of Theology
2022
Center for Digestive and Liver Diseases
2022
Juntendo University Hospital
2021
Hokkaido University
2002
The University of Tokyo
1963-1999
Tokyo University of Agriculture
1963-1988
Niigata University
1985
Psychiatry Baselland
1985
EUS-guided hepaticogastrostomy (EUS-HGS) is an effective salvage procedure when conventional endoscopic transpapillary biliary drainage difficult or fails. However, the risk of stent migration into abdominal cavity has not been resolved completely. In this study, we evaluated a newly developed partially covered self-expandable metallic (PC-SEMS) that spring-like anchoring function on gastric side.This retrospective pilot study took place at four referral centers in Japan between October 2019...
ABSTRACT Background and Objectives Recent technological advances in interventional EUS have improved EUS-guided drainage/anastomosis (EUS-D/A), yet challenges remain. This study evaluated the safety feasibility of a square flare fully covered self-expandable metallic stent (SF-FCSEMS) with anti-migration properties for EUS-D/A. Methods retrospective cohort was performed at 2 academic centers analyzed patients who underwent SF-FCSEMS placement EUS-D/A from April 2015 to November 2022. We used...
Background: Endoscopic ultrasound-guided hepaticogastrostomy (EUS-HGS) is becoming increasingly popular. However, the risk factors for stent migration into abdominal cavity remain unknown. Methods: Forty-eight patients undergoing EUS-HGS with placement of a long, partially covered self-expandable metallic (LPC-SEMS) were studied retrospectively to identify migration. We determined technical and functional success rates, recorded adverse events, including Results: was technically successful...
Management of bile duct stones (BDSs) in patients with surgically altered anatomies (SAAs) remains challenging. An endoscopic ultrasound-guided antegrade (EUS-AG) procedure and double-balloon enteroscopy-assisted retrograde cholangiography (DB-ERC) have been used to remove BDSs from SAAs. However, few comparative data reported. Therefore, we compared the efficacy safety techniques.This was a single-center retrospective study. Patients SAA who underwent EUS-AG or DB-ERC intra- extra-BDSs...
Abstract Endoscopic ultrasound (EUS)‐guided pancreatic duct drainage includes two procedures: EUS‐guided drainage/anastomosis (EUS‐D/A) and trans‐papillary with EUS‐assisted rendezvous. pancreatogastrostomy is the most common EUS‐D/A procedure recommended as a salvage in cases which endoscopic retrograde cholangiopancreatography fails or difficult. However, initial performed patients surgically altered anatomy at our institution. It one of difficult interventional EUS procedures has high...
Cystathionine γ-synthase (CGS) catalyzes the first committed step of Met biosynthesis in plants. We have previously shown that expression gene for CGS is feedback-regulated at level mRNA stability, and amino acid sequence encoded by exon itself responsible regulation (Chiba, Y., Ishikawa, M., Kijima, F., Tyson, R. H., Kim, J., Yamamoto, A., Nambara, E., Leustek, T., Wallsgrove, Naito, S. (1999) Science 286, 1371–1374). To identify functional region within 1, deletion analysis was performed....
Objectives Endoscopic ultrasound/endosonography-guided pancreaticogastrostomy (EUS-PGS) is a useful alternative when endoscopic retrograde pancreatography difficult. Recently, many procedures, including peroral pancreatoscopy (POPS), have been performed through the mature fistula (MF) created by EUS-PGS. We evaluate efficacy and safety of POPS to diagnose treat pancreatic ductal stricture/pancreato-jejunal anastomotic stricture (PDS/PJAS) MF. Methods Twenty patients underwent EUS-PGS; 13...
Plastic stents are placed at anastomosis sites after endoscopic ultrasound-guided pancreaticogastrostomy (EUS-PGS) [1] [2]. Straight plastic have better pushability than double-pigtail but more prone to migrate. We report a case of straight stent that migrated into the pancreatic duct (PD) and was successfully retrieved. It had been during EUS-PGS. The distal end located tail side puncture point retrieved using guidewire technique by peroral pancreatoscopy (POPS).
Background/Objective: Interventional endoscopic ultrasound (I-EUS) is technically difficult and has risks of severe adverse events due to the scarcity dedicated endoscopes tools. A new EUS scope was developed for I-EUS modified increase puncture range, reduce blind area, overcome guidewire difficulties. We evaluated usefulness safety a compared conventional scope. Methods: All procedures were performed at Juntendo University Hospital from April 2020 2022. The primary outcomes included...
A decrease in carbohydrate antigen (CA) 19-9 levels has been proposed as a prognostic marker for survival and recurrence patients with pancreatic cancer. We evaluated the association between duration of reduced CA during 6 months after treatment long-term 79 unresectable locally advanced cancer (LAPC). calculated differences pretreatment monthly CA19-9 levels. categorized 71 decreases into three groups based on these (>2, >3, >4 months). The cut-off level (more than 2 years) was...
Piericidin B was isolated from mycellia of Streptomyces mobaraensis besides piericidin A. On the basis IR, NMR and mass spectral studies together with chemical evidences, its structure assigned as Id. Its physiological activities are also deescribd.
Background and Aim:A sufficiently open papilla is needed to remove common bile duct stones (CBDS) but endoscopic sphincterotomy (EST) requires a high level of skill difficult with papillary balloon dilation (EPBD).The main adverse event (AE) EST bleeding perforation that EPBD post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis.To reduce these AEs, we employed minimal followed by (ESBD), retrospectively evaluated its efficacy safety compared EST.Methods: CBDS patients who...
The emergency declaration (ED) associated with the coronavirus disease-2019 (COVID-19) pandemic in Japan had a major effect on management of gastrointestinal endoscopy. We retrospectively compared number pancreaticobiliary endoscopies and newly diagnosed cancers before (1 April 2018 to 6 2020), during (7 25 May after ED (26 31 July). Multiple comparisons three groups were performed respect presence or absence symptoms clinical disease stage. There no significant differences among...
Monoclonal antibody therapy is a promising option for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, and cocktail of antibodies (REGN-COV) has been administered to infected patients with favorable outcome. However, it necessary continue generating novel sets monoclonal neutralizing activity because viral variants can emerge that show resistance the currently utilized antibodies. Here, we isolated new antibodies, EV053273 EV053286, from peripheral blood mononuclear...
Interventional endoscopic ultrasonography is performed for various situations that require drainage, after which stent migration the most severe adverse event. Several lumen-apposing metal stents (LAMS) and covered self-expandable (CSEMS) provide antimigration systems; however, their anchoring ability has not been studied well. Therefore, we measured compared force (ACF) of commercially available LAMS CSEMS.Anchoring was five types (NAGI, SPAXUS, Plumber, AXIOS 8 10 mm) seven CSEMS (BCL,...
Structure of a New Fungal Pyrone, from an Unidentified Penicillium sp. Get access Yasuo Kimura, Kimura Department Agricultural Chemistry, The University Tokyo, Bunkyo-ku, Tokyo 113 Search for other works by this author on: Oxford Academic Google Scholar William J McGahren, McGahren Lederle Laboratories, A Division American Cyanamid Company, Pearl River, York 10965 Akinori Suzuki, Suzuki Saburo Tamura and Biological Volume 42, Issue 8, 1 August 1978, Pages 1625–1626,...
Interventional endoscopic ultrasound-guided procedures (I-EUS) are widely accepted as salvage in ERCP-failed cases, and to drain fluid collected the abdominal cavity. Although I-EUS has a relatively high incidence of complications is severe/fatal some no follow-up strategy been established. In our institution, plain computed tomography (P-CT) performed routinely day after I-EUS. this study, we evaluated usefulness routine P-CT I-EUS, method, propose an algorithm.We retrospectively reviewed...
An Enterococcus faecalis plasmid, pAM373, has a high frequency of transfer in liquid medium when induced by recipient-produced sex pheromone, cAM373. The pheromone inhibitor against cAM373, termed iAM373, was isolated from culture supernatant E. harboring pAM377 (= pAM373::Tn917), and its structure identified as heptapeptide, H-Ser-Ile-Phe-Thr-Leu-Val-Ala-OH).