A5019987369- Prostate Cancer Treatment and Research
- Tissue Engineering and Regenerative Medicine
- Urinary Bladder and Prostate Research
- Urological Disorders and Treatments
- Cancer, Lipids, and Metabolism
- Hippo pathway signaling and YAP/TAZ
- Cancer Genomics and Diagnostics
- Prostate Cancer Diagnosis and Treatment
- Chemical Reactions and Isotopes
- Epigenetics and DNA Methylation
- Hormonal and reproductive studies
- Urologic and reproductive health conditions
- Xenotransplantation and immune response
- Cancer, Hypoxia, and Metabolism
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Cancer-related molecular mechanisms research
- Proteoglycans and glycosaminoglycans research
- Estrogen and related hormone effects
Northwestern University
2023
University of Illinois Chicago
2019-2022
University of Chicago
2016-2019
The molecular roles of HOX transcriptional activity in human prostate epithelial cells remain unclear, impeding the implementation new treatment strategies for cancer prevention and therapy. MEIS proteins are transcription factors that bind direct protein activity. putative tumor suppressors frequently silenced aggressive forms cancer. Here we show MEIS1 expression is sufficient to decrease proliferation metastasis vitro vivo murine xenograft models. HOXB13 deletion demonstrates...
The development of androgen receptor signaling inhibitor (ARSI) drug resistance in prostate cancer (PC) remains therapeutically challenging. Our group has described the role sex determining region Y-box 2 (SOX2) overexpression ARSI-resistant PC. Continuing this work, we report that NR3C1, gene encoding glucocorticoid (GR), is a novel SOX2 target PC, positively regulating its expression. Similar to ARSI treatment, SOX2-positive PC cells are insensitive GR inhibition using modulating therapy....
Abstract Identification of defined epithelial cell populations with progenitor properties is critical for understanding prostatic development and disease. Here, we demonstrate that Sox2 expression enriched in the cells proximal prostate adjacent to urethra. We use lineage tracing Sox2-positive during development, homeostasis, regeneration show capable self-renewal contributes regeneration. Persisting luminal express after castration, highlighting a potential role survival...
A fundamental understanding of prostate development and tissue homeostasis has the high potential to reveal mechanisms for disease initiation identify novel therapeutic approaches prevention treatment. Our current lineage specification stems from use developmental model systems that rely upon embryonic preprostatic urogenital sinus mesenchyme induce formation mature epithelial cells. It is unclear, however, how epithelium can derive both adult urethral glands epithelia. Furthermore, vast...
You have accessJournal of UrologyBenign Prostatic Hyperplasia: Basic Research & Pathophysiology1 Apr 2017MP17-13 MAGNETIC RESONANCE IMAGING STUDIES OF AN EXPERIMENTAL MOUSE MODEL LOWER URINARY TRACT SYMPTOMS ASSOCIATED WITH BENIGN PROSTATIC HYPERPLASIA Erin McAuley, Devkumar Mustafi, Brian Simons, Rebecca Valek, Marta Zamora, Erica Markiewicz, Sophia Lamperis, Greg Karczmar, Aytekin Oto, and Donald Vander Griend McAuleyErin McAuley More articles by this author , MustafiDevkumar Mustafi...
You have accessJournal of UrologyCME1 May 2022PD07-09 MEIS PROTEINS INHIBIT HOXB13-DEPENDENT PROSTATE CANCER METASTASIS AND ANDROGEN RECEPTOR SIGNALING Srikanth Perike, Calvin VanOpstall, Mathias Morales, Sophia Lamperis, Steve Kregel, Ryan Brown, and Donald J. Vander Griend PerikeSrikanth Perike More articles by this author , VanOpstallCalvin VanOpstall MoralesMathias Morales LamperisSophia Lamperis KregelSteve Kregel BrownRyan Brown GriendDonald View All Author...
You have accessJournal of UrologyProstate Cancer: Basic Research & Pathophysiology II (PD44)1 Sep 2021PD44-06 MEIS PROTEINS INHIBIT HOXB13-DEPENDENT PROSTATE CANCER METASTASIS AND ANDROGEN RECEPTOR SIGNALING Srikanth Perike, Calvin VanOpstall, Ryan Brown, Sophia Lamperis, and Donald J. Vander Griend PerikeSrikanth Perike More articles by this author , VanOpstallCalvin VanOpstall BrownRyan Brown LamperisSophia Lamperis GriendDonald View All Author...