A5100391804- Sirtuins and Resveratrol in Medicine
- Adipose Tissue and Metabolism
- Autophagy in Disease and Therapy
- Frailty in Older Adults
- Calcium signaling and nucleotide metabolism
- Nutrition and Health in Aging
- PARP inhibition in cancer therapy
- Biochemical effects in animals
- Tea Polyphenols and Effects
- Bioactive natural compounds
- Cardiac Fibrosis and Remodeling
- Cardiac, Anesthesia and Surgical Outcomes
- Cerebral Palsy and Movement Disorders
- RNA Interference and Gene Delivery
- RNA regulation and disease
- Calpain Protease Function and Regulation
- Occupational and environmental lung diseases
- Cardiac Ischemia and Reperfusion
- Curcumin's Biomedical Applications
- Redox biology and oxidative stress
- Toxin Mechanisms and Immunotoxins
- Hematopoietic Stem Cell Transplantation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Toxoplasma gondii Research Studies
Institute of Hematology & Blood Diseases Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Academy of Medical Sciences
2024
Huazhong University of Science and Technology
2008-2023
The First People's Hospital of Changzhou
2022-2023
Tongji Hospital
2008-2022
Weifang Medical University
2021
First People's Hospital of Foshan
2020-2021
Shanghai Changzheng Hospital
2021
Shantou University
2008-2018
Abstract Resveratrol, a polyphenol found in fruits, has been demonstrated to activate Sir2. Though many studies have that resveratrol can SIRT1, whether it effect on other sirtuins (SIRT2–7) are unknown. The present study shows exposure of H9c2 cells 50 µM H 2 O for 6 h caused significant increase apoptosis, as evaluated by TUNEL and flow cytometry (FCM), but pretreatment (20 µM) eliminated ‐induced apoptosis. Resveratrol also prevented caspase‐3 activation. Exposure rapid activation...
trans-Resveratrol (resveratrol) has been shown to have beneficial effects on the cardiovascular system in a number of studies. It is, however, unclear whether this naturally occurring compound can protect against cardiac hypertrophy. The aim present study was investigate resveratrol hypertrophy vivo and potential underlying mechanisms involving endothelin (ET), angiotensin (Ang) II nitric oxide (NO) partially nephrectomized rats. Animal models bearing were replicated male Sprague-Dawley rats...
Trans-10, cis-12 conjugated linoleic acid (t10c12 CLA) reduces triglyceride (TG) levels in adipocytes through multiple pathways, with AMP-activated protein kinase (AMPK) generally facilitating, and peroxisome proliferator-activated receptor γ (PPARγ) opposing these reductions. Sirtuin 1 (SIRT1), a histone/protein deacetylase that affects energy homeostasis, often functions coordinately AMPK, is capable of binding to PPARγ, thereby inhibiting its activity. This study investigated the role...
Calorie restriction (CR) extends the lifespan of mammals and improves cardiac function by attenuation age‑associated alterations. Sirtuins (SIRT) are involved in these mechanisms, however, extent to which CR affects sirtuin expression remains unknown. Therefore, present study aimed determine what expression. A total 60 female Sprague‑Dawley rats were randomly divided into four groups, including normal control (NC), 25% calorie (25% CR), 45% (45% CR) high‑fat diet (HF). The groups maintained...
Summary 1. trans ‐Resveratrol (resveratrol) has been shown to have beneficial effects on the cardiovascular system in a number of studies. It is, however, unclear whether this naturally occurring compound can protect against cardiac hypertrophy. The aim present study was investigate resveratrol hypertrophy vivo and potential underlying mechanisms involving endothelin (ET), angiotensin (Ang) II nitric oxide (NO) partially nephrectomized rats. 2. Animal models bearing were replicated male...
Abstract Atherosclerosis is a chronic immuno‐inflammatory disease associated with blood lipids disorder. Many studies have demonstrated that caloric restriction (CR) can prevent atherosclerosis and extend lifespan. Sir2 protein, mammal's SIRT1, has been reported to at least partly contribute the protective effect of CR. Hence, we hypothesize SIRT1 key regulator in pathogenesis upregulation endothelial cells may mimic CR's beneficial on vascular health. The recent an anti‐atherosclerosis...
Calorie restriction (CR) has been shown to increase longevity and mitigate age‑associated diseases in various organisms. Numerous studies have identified that sirtuin 1 (SIRT1) is upregulated by CR. However, the expression of SIRT isoforms 2‑7 response CR cardiomyocytes yet be elucidated. Therefore, present study aimed investigate cellular localization SIRT1‑7 cardiomyocytes. Twenty SD rats were fed either ad libitum (AL) or a diet (60% AL) for three weeks. In addition, H9c2 cells cultured...
Atherosclerosis (AS) is a chronic immuno‑inflammatory disease accompanied by dyslipidemia. The authors previously demonstrated that sirtuin 1 (SIRT1) may prevent atherogenesis through influencing the liver X receptor/C‑C chemokine receptor type 7/nuclear factor‑κB (LXR‑CCR7/NF‑κB) signaling pathway. Previous studies have suggested role for mammalian target of rapamycin (mTOR) in pathogenesis cardiovascular diseases. present study investigated potential association between mTOR and...
Abstract Purpose To investigate the frailty status in Chinese cancer patients through establishing a novel prediction algorithm. Methods The percentage of various age groups, locations, and tumor types was investigated. capacity on mortality analysed by index composing routine laboratory data (FI‐LAB) accessible from blood test calculated as ratio abnormal factors to 22 total variables. establishment algorithm, MCP (mortality patients), predict 5‐year accomplished algorithm's tested training...
Osteoarthritis (OA) affects approximately 12% of the aging Western population. The sirtuin/forkhead box O (SIRT/FOXO) signaling pathway plays essential roles in various biological processes. Despite it has been demonstrated that ubiquitin-specific protease 3 (USP3) inhibits chondrocyte apoptosis induced by interleukin (IL)-1β, role USP3/SIRT3/FOXO3 senescence chondrocytes OA is unclear. This study initially isolated articular and investigated USP3 IL-1β-induced chondrocytes. After was...
Diabetic cardiomyopathy (DCM) is a major complication of type 2 diabetes mellitus (T2DM) that significantly contributes to morbidity and mortality. Streptozotocin (STZ) was used induce the formation (DM) model in rats research effect curcumin on diabetic cardiomyopathy. DM showed typical phenotypes such as increased blood glucose, decreased insulin, impaired cardiac function. After treatment, dysfunction serum levels were improved. At same time, apoptosis cardiomyocytes expression Sirt3...
Irradiation with X-rays has been widely utilized in the clinical treatment of solid tumors and certain hematopoietic malignancies. However, this method fails to completely distinguish between malignant normal cells. Prolonged or repeated exposure radiation, whether due occupational hazards therapeutical interventions, can cause damage tissues, particularly impacting system. Therefore, it is important investigate effects total body irradiation on system mice compare inhibitory various doses...