A5028720758- Neuroscience of respiration and sleep
- Neuropeptides and Animal Physiology
- Migraine and Headache Studies
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Anesthesia and Neurotoxicity Research
- Thermal Regulation in Medicine
- Pain Mechanisms and Treatments
- Trigeminal Neuralgia and Treatments
- Nitric Oxide and Endothelin Effects
- High Altitude and Hypoxia
- Memory and Neural Mechanisms
- Adipose Tissue and Metabolism
- Eicosanoids and Hypertension Pharmacology
- Advanced Materials and Mechanics
- Pain Management and Placebo Effect
- Neurogenesis and neuroplasticity mechanisms
- Radiopharmaceutical Chemistry and Applications
- Long-Term Effects of COVID-19
- Conducting polymers and applications
- Receptor Mechanisms and Signaling
- Sleep and Wakefulness Research
- Acupuncture Treatment Research Studies
- Nasolacrimal Duct Obstruction Treatments
- Mechanisms of cancer metastasis
RWTH Aachen University
2025
University of Liège
1996-2020
Friedrich-Alexander-Universität Erlangen-Nürnberg
2003-2018
Institute of Physiology National Academy of Sciences of Belarus
2001-2013
Calcitonin gene-related peptide (CGRP) has been suggested to play a major role in the pathogenesis of migraines and other primary headaches. CGRP may be involved control neuronal activity spinal trigeminal nucleus (STN), which integrates nociceptive afferent inputs from tissues, including intracranial afferents. The STN neurons is thought reflect central pathways causing facial pain headaches humans. In rat model meningeal nociception, single was recorded. All units had receptive fields...
Abstract Peripheral nerve injury is associated with severe loss of life quality, often requiring surgical intervention. Nerve guidance conduits (NGCs) support regeneration by guiding axonal outgrowth and Schwann cell migration. Conductive NGCs are high interest, as they mimic the healthy nerve, thus improving therapeutic outcomes. This study presents a microfluidic spinning process for fabrication poly(3,4‐ethylene dioxythiophene) polystyrene sulfonate (PEDOT:PSS) microfibers. A...
Nitric oxide is thought to control transmitter release and neuronal activity in the spinal dorsal horn trigeminal nucleus, where nociceptive information from extra- intracranial tissues processed. Extracellular impulse was recorded neurons rat nucleus with afferent input cranial dura mater. In contrast inactive isomer D-NAME, infusion of nitric synthase inhibitor L-NAME (20 mg/kg) significantly reduced increased systemic blood pressure. It concluded that production contributes ongoing...
Calcitonin gene-related peptide (CGRP) plays a major role in the pathogenesis of migraine and other primary headaches. Spinal trigeminal neurons integrate nociceptive afferent input from tissues including intracranial afferents, their activity is thought to reflect facial pain headache man. CGRP receptor inhibitors anti-CGRP antibodies have been demonstrated be therapeutically effective migraine. In parallel, inhibition has shown lower spinal neuron animal models meningeal nociception. rat...
Hypothesis on migration of stem cells to injured brain region after introduction into nasolacrimal duct has been experimentally verified Wistar rats (n=7).Fluorescent have detected in the frontal cerebral cortex using confocal microscopy 20 hours implantation mesenchymal rats.
The article contains analysis of perspectives cell technologies use in the therapy patients with Alzheimer's disease (AD).Currently there are no effective ways to diagnose this at early stage.Late diagnostics AD and weak understanding its mechanisms complicate clinical tactics leaving fact palliative (symptomatic) treatment as only available option.Authors propose a combination traditional methods newly developed technologies.Stem cells (SC) implantation is basis for recovery functional...
Deep body temperature of 57 male Wistar rats was measured in response to systemic (i.v. or i.p.) injection Escherichia coli lipopolysaccharide (LPS). Animals were preliminarily (4 weeks before the experiment) treated with microinjections toxic dose glutamate receptors agonists vehicle into solitary tract nucleus caudal part ventrolateral medulla. Microinjections provoked a local destruction brain tissue, which accompanied by significant transformation (amplification attenuation) 3 μg/kg E....
Nozizeptive Mechanismen im trigeminovaskulären System der Hirnhäute sind vermutlich an Entstehung von Kopfschmerzen unterschiedlichster Ursachen beteiligt. Dabei wird dem Neuropeptid CGRP (Calcitonin gene-related peptide), das einem Teil aktivierten primären Afferenzen des N. trigeminus freigesetzt wird, eine entscheidende Rolle zugeschrieben. wirkt nicht nur stark vasodilatorisch, sondern ist auch synaptischen Übertragung Trigeminuskern Die Hemmung CGRP-Rezeptoren durch den hochaffinen...
ABSTRACT Although the fast antidepressant effect of ketamine is now well established clinically, neither its mechanism(s) nor main site(s) action clearly defined. Because enhanced serotoninergic (5-HT) transmission an important part various drug classes, we asked whether and one metabolites (hydroxynorketamine [HNK]), both used in their racemic form, may modulate excitatory drive onto these neurons. Using whole-cell recordings from pharmacologically identified 5-HT non-5-HT neurons juvenile...
Experiments on 33 Wistar rats were performed to test two interrelated hypotheses. Firstly, is the migration of fluorescein isothiocyanate (FITC) labeled endotoxin (Escherichia coli lipopolysaccharide, LPS) (5.0 μg in 5.0 μl sterile water) via olfactory nerve into brain after single submucous injection LPS real? Secondly, case such feasible, it possible explain a number clinical signs patients infected with COVID-19 using obtained facts? We are talking namely about symptoms damage terminals...