A5091277409- Spine and Intervertebral Disc Pathology
- Ovarian cancer diagnosis and treatment
- Reproductive System and Pregnancy
- Prenatal Screening and Diagnostics
- Musculoskeletal pain and rehabilitation
- Reproductive tract infections research
- Knee injuries and reconstruction techniques
- Preterm Birth and Chorioamnionitis
- Neonatal and Maternal Infections
- Endometrial and Cervical Cancer Treatments
- Surgical Simulation and Training
- Orthopedic Surgery and Rehabilitation
- Medical Imaging and Analysis
- Animal Genetics and Reproduction
- Sperm and Testicular Function
- Antibiotics Pharmacokinetics and Efficacy
- Scoliosis diagnosis and treatment
- Estrogen and related hormone effects
- Anatomy and Medical Technology
- Assisted Reproductive Technology and Twin Pregnancy
- Ovarian function and disorders
- Antibiotic Resistance in Bacteria
- Testicular diseases and treatments
- Neonatal Respiratory Health Research
- CRISPR and Genetic Engineering
Tokushima University
2024-2025
Sapporo Medical University
2016-2024
Otaru Municipal Hospital
2015-2023
Hokkaido University
1988-2004
Rockefeller University
1975
Michigan State University
1973-1974
Michigan Department of Agriculture and Rural Development
1974
While there are undoubtedly multiple causes of spontaneous abortion and congenital birth defects, high incidences chromosomal abnormalities in human abortuses (Carr, 1965; Geneva Conference, 1966; Makino & co\ x=r eq-\ authors, 1967; Ikeuchi, Sasaki, Kohno, Hayata Fujimoto, 1972), early embryos the pig (McFeely, 1967) suggest that imbalance may be one primary embryonic death.Excessive administration HCG has been reported to affect sperm capacitation rabbits (Soupart, Wettemann Hafs, 1970),...
Neospora caninum tissue cysts were found in the brains of surgically delivered twin fetuses at 119 days gestation. In both fetuses, there was an inflammatory reaction involving perivascular cuffings mononuclear cells, glial nodules. The dam these died because metritis. Histopathological examination ewe revealed N. and focal gliosis with cell cuffings. A caninum-specific DNA fragment detected a brain homogenate by polymerase chain method. This is first report infection ovine adult sheep.
The incidence of endometrial cancer and ovarian in Japan has been increasing recent years. Results epidemiologic studies suggest that the onset multiplication these cancers are associated with estrogen. Estrogens metabolized by cytochrome P450 1A1 (CYP1A1) converted into catecholestrogens, which carcinogens. CYP1A1 several polymorphisms, major one being T6235C transition non-coding 3'-flanking region (MspI polymorphism), another A4889G exon 7 (Ile/Val polymorphism). These polymorphisms can...
A case of a 62 year old Japanese woman with an endometrial adenocarcinoma producing alpha-fetoprotein (AFP) is described. Microscopically, the tumour was composed major medullary portion and minor tubular which had invaded myometrium, myometrial lymphatics blood vessels. Neoplastic cells in were polygonal glycogen-rich cytoplasm. Vascular permeation by neoplastic prominent. Extensive hepatoma-like features observed. The lacked suggestive diagnosis embryonal carcinoma or endodermal sinus...
The distribution of lymph node metastasis and the clinicopathologic risk factors for nodal involvement in ovarian carcinoma need to be clarified based on systematic dissection. We studied 115 patients with who underwent pelvic para-aortic dissection between 1987 1997. incidence are described clinico-pathologic investigated. Based occurrence early stages, solitary metastasis, we conclude that primary site is (PAN), especially PAN superior inferior mesenteric artery (IMA). By univariate...
We found a significant correlation between lung cancer in smokers and the expression of human gene, D40, predominantly expressed testis cancers. In an attempt to clone novel we screened cDNA library derived from B cell line obtained that refer as D40. A search for public databases sequence homologies showed D40 gene is identical AF15q14. mRNA normal tissue. However, this also various tumour lines primary tumours organs tissues, such cancer. examined relationship clinico-pathological...
Although granulocyte-colony stimulating factor (G-CSF) is commonly used in the field of supportive therapy for cancer treatment, serum concentration endogenous G-CSF healthy women still obscure due to low sensitivity (30 pg mL-1) usual enzyme immunoassay. With development a highly sensitive (1.0 chemiluminescent immunoassay by Kiriyama et al., we have clarified changes levels during menstrual cycle and pregnancy. The showed peak value 27.3 +/- 2.5 mL-1 (mean SEM) at ovulatory phase cycle,...
Study Design. A retrospective cohort study of consecutive patients. Objective. To investigate whether adequate flexion-extension was acquired in standard functional radiographs lumbar spondylolisthesis. Summary Background Data. In spondylolisthesis, taken the standing position are most commonly used to evaluate spinal instability. However, these occasionally depend on patient's effort and cooperation, they can provide different results. Methods. This included 92 patients diagnosed with L4 -5...
The aim of this trial was to investigate the efficacy massive i.v. immunoglobulin (MIVIg) treatment for women with a history recurrent spontaneous abortion (RSA) due unexplained aetiology. study included nine (11 pregnancies) four or more consecutive RSA aetiology and no live births. mean number fetal losses 4.5 (range 4-6 abortions). Over course 5 days, (20 g/day) infused at gestational weeks 4-7. No additional infusions were carried out. Two pregnancies out 11 conceptions resulted in...
Full endoscopic spine surgery continues to spread worldwide but has a long learning curve. Conventional endoscopy training uses live pigs or human cadavers, which disadvantages such as high costs and limited availability. Therefore, this study aimed develop evaluate three-dimensional (3D)-printed models for training.
We developed a new kit for detecting alpha-fetoprotein (AFP) in leaked amniotic fluid (Eur J Obstet Gynecol Reprod Biol 1995;58:67-72). Later, we an improved AFP utilizing the same monoclonal antibody. compared this test with nitrazine 137 patients. The correctly diagnosed 62.1% of cases, but 98.0% < 37 weeks gestation (P 0.001). showed specificity 58.3%, whereas 100% rate > or = 0.01). reaction time is 90 s. This study has confirmed high clinical efficacy as method diagnosis premature...
Endometrial carcinoma is a common malignancy of the genital tract. In present study, we examined expression human steroidogenic acute regulatory (StAR) protein, P450 side-chain cleavage enzyme (P450 scc), 17alpha-hydroxylase/17,20-desmolase (P45017alpha) and aromatase arom) in endometrial cells to clarify ability these produce steroid hormones. The results RT-PCR analysis showed that StAR, scc P45017alpha genes were expressed cells. To examine protein StAR scc, performed Western blotting...
Study Design: Cross-sectional study.Purpose: The purpose of this study was to elucidate the relevance among Schmorl’s node (SN), chronic low back pain (CLBP), and intervertebral disc degeneration (IVDD) with use magnetic resonance imaging T2 mapping.Overview Literature: SN may be combined CLBP and/or IVDD; however, their relationship has not been determined date.Methods: A total 105 subjects were included (48 men 57 women; mean age, 63.2±2.7 years; range, 22–84 years). We analyzed five...
Chromosomal imbalance is causally related to some developmental anomalies and increased death in early embryos of human laboratory animals.High incidences chromosomal abnormalities have been reported cases spontane ous abortion (Carr 1965, Geneva Conference 1966, Makino et al. 1967, Ikeuchi 1972).In addition, Carr (1970) Mikamo (1971) an incidence spontaneous abortuses with triploid chromosome components from mothers who had taken oral contraceptives.The increasing interest reproductive...
Current literature indicates that chromosomal imbalance is causally related to some developmental anomalies and wastages in utero.While the incidence of gross abnormalities human newborn population esti- mated be 0\m=.\5%(Lubs & Ruddle, 1970), much higher incidences have been reported spontaneous threatened abortions (Carr, 1965; Geneva
Leptomeningeal metastasis is a rare entity and its diagnosis often difficult. Moreover, evidence-based therapeutic strategies have not yet been established. A 52-year-old woman presented with high fever was diagnosed bacterial meningitis at first examination;although her alleviated, she experienced motor weakness in both of lower extremities. Ga scintigraphy highlighted the hot-spot areas disease cranial bone. She then transferred to our department. Open biopsy skull showed cancer. Chest CT...