A5078413369- Animal Nutrition and Physiology
- Coccidia and coccidiosis research
- Protein Hydrolysis and Bioactive Peptides
- Antimicrobial Peptides and Activities
- Dielectric materials and actuators
- Polymer composites and self-healing
- Lignin and Wood Chemistry
- Cancer Cells and Metastasis
- Electromagnetic wave absorption materials
- Probiotics and Fermented Foods
- Advanced Antenna and Metasurface Technologies
- Veterinary medicine and infectious diseases
- Medical Imaging Techniques and Applications
- Advanced Sensor and Energy Harvesting Materials
- Phytase and its Applications
- Bee Products Chemical Analysis
- Synthesis and properties of polymers
- Polymer Nanocomposites and Properties
- Cancer, Hypoxia, and Metabolism
- Spectroscopy and Quantum Chemical Studies
- Advanced Radiotherapy Techniques
- Meat and Animal Product Quality
- biodegradable polymer synthesis and properties
- Functional Brain Connectivity Studies
- Enzyme Production and Characterization
United States Department of Agriculture
2020-2025
Beltsville Agricultural Research Center
2019-2025
Sungkyunkwan University
2002-2024
Agricultural Research Service
2019-2024
Seoul National University
2015-2023
The University of Texas Southwestern Medical Center
2021-2022
Yonsei University
2021-2022
Samsung Medical Center
2021
Suwon Research Institute
2020
Institute for Basic Science
2020
Patients generally die of cancer after the failure current therapies to eliminate residual disease. A subpopulation tumor cells, termed stem cells (CSC), appears uniquely able fuel growth phenotypically and histologically diverse tumors. It has been proposed, therefore, that effectively treat may in part be due preferential resistance these CSC chemotherapeutic agents. The human colorectal with an ESA(+)CD44(+) phenotype are responsible for tumorigenesis have capacity generate heterogeneous...
The Wnt/β-catenin pathway, which signals through the Frizzled (Fzd) receptor family and several coreceptors, has long been implicated in cancer. Here we demonstrate a therapeutic approach to targeting Wnt pathway with monoclonal antibody, OMP-18R5. This initially identified by binding 7, interacts five Fzd receptors conserved epitope within extracellular domain blocks canonical signaling induced multiple members. In xenograft studies minimally passaged human tumors, this antibody inhibits...
Stem cells generate the differentiated cell types within many organs throughout lifespan of an organism and are thus ultimately responsible for longevity multicellular organisms. Therefore, senescence stem must be prevented. Bmi1 is required maintenance adult in some tissues partly because it represses genes that induce cellular death.
Abstract Utilization of carbon-neutral biomass became increasingly important due to a desperate need for carbon reduction in the issue global warming light replacing petroleum-based materials. We used lignin, which was an abundant, low cost, and non-food based biomass, development all biomass-based films composites through reactive compatibilization with poly (lactic-acid) (PLA). Using facile practical route, hydrophilic hydroxyl groups lignin were acetylated impose compatibility PLA. The...
This study was to determine apparent ileal digestibility of acid detergent fiber (ADF), neutral (NDF), dry matter (DM), energy, organic (OM), crude ash, digesta viscosity, and gut morphology in nursery pigs fed diets containing xylanase (Lohmann Animal Nutrition GmbH, Cuxhaven, Germany). The diet (61% corn, 35% soybean meal, 1% poultry fat, 3% minerals vitamins) mixed with 3 levels (0, 700, 1400 LXU/kg). Thirty-six barrows (17.6 ± 3.3 kg) received one treatment based on a randomized complete...
The objective of this study was to investigate the effects dietary Bacillus subtilis supplementation on growth performance, jejunal lesion scores, oocyst shedding, and cytokine tight junction protein expression in broiler chickens infected with Eimeria maxima. A total 196 male day-old Ross 708 broilers were given a nonexperimental diet until 14 D age. Then, all randomly assigned one seven treatments: 2 basal diets (CON NC); CON + virginiamycin (AB1); bacitracin methylene disalicylate (BMD;...
As electromagnetic (EM) pollution continues to increase, interference (EMI) shielding materials have been intensively evaluated in terms of two main mechanisms reflection and absorption. Since the effectiveness (SE) is represented logarithmic scale a coupled way transmission (SET), absorption (SEA), (SER), often there misinterpretation that EM wave reflectors are regarded as wave-absorbing materials. Surprisingly, we found many reported an absorber literature provide, fact, less than 50%...
Although the typical antioxidant, N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD), ensures high durability and long lifespan for rubber compounds, it generates a highly toxic quinone in water, causing serious environmental pollution. Herein, as an alternative material of 6PPD, we newly introduce eco-friendly amine-functionalized lignin (AL) to be incorporated rubber, which can provide excellent combinatorial antiaging properties thermal stability ozone/fatigue resistances through...
Mycotoxins are produced by fungi and potentially toxic to pigs. Yeast cell wall extract (YCWE) is known adsorb mycotoxins improve gut health in One hundred twenty growing (56 kg; experiment 1) 48 nursery piglets (6 2) were assigned four dietary treatments a 2 × factorial design for 35 days, respectively. Factors (no addition versus 1: 180 μg/kg aflatoxins 14 mg/kg fumonisins; or 2: 9 fumonisins, 1 deoxynivalenol) YCWE (0% 0.2%). Growth performance, blood, microbiome, apparent ileal...
Abstract The regulation of hematopoietic stem cell (HSC) homeostasis is not well understood. We screened for genetic polymorphisms that were linked to differences between mouse strains in the numbers long-term reconstituting HSCs or restricted progenitors bone marrow. AKR/J mice had significantly higher frequencies and both their marrow than C57BL/Ka-Thy-1.1 mice. alleles partially dominant. A locus on chromosome 17, including H-2 complex, was frequency self-renewing but showed no evidence...
We recently reported a stable Bacillus subtilis-carrying chicken NK-lysin peptide (B. subtilis-cNK-2) as an effective oral delivery system of antimicrobial to the gut with therapeutic effect against Eimeria parasites in broiler chickens. To further investigate effects higher dose B. subtilis-cNK-2 treatment on coccidiosis, intestinal health, and microbiota composition, 100 (14-day-old) chickens were allocated into 4 groups randomized design: 1) uninfected control (CON), 2) infected without...
This study was conducted to investigate the effects of a phytochemical mixture containing full spectrum cinnamon, clove, and oregano essential oils (CCO) on growth performance, intestinal immunity, integrity broilers infected with coccidiosis. In chicken macrophage cells (CMCs), inflammation induced 1.0 µg/mL LPS, followed by stimulating CCO at three concentrations (1.0, 10.0, 100 µg/mL) measuring gene expression levels IL-1β IL-8. epithelial (IECs), added cultured, occludin, ZO-1, MUC2 were...
Abstract The pristine lignin molecules contain multiple reactive hydroxyl [OH] groups, some of which undergo limited polymerization depending on their configuration (aromatic or aliphatic) conformation. key issue in lignin-polymerization is to quantify the number groups for subsequent activation specific lignin-polymer chain lengths degree grafting. In this study, using ε-caprolactone (CL) as a solvent, we successfully polymerized CL sites kraft macromonomers (LM, M w = 1,520 g mol −1 ),...
Direct-fed microbials (DFMs) are dietary supplements containing live microorganisms which confer a performance and health benefit to the host, but mechanisms unclear. Here, metabolomics approach was used identify changes in intestinal metabolite levels chickens fed an unsupplemented diet or supplemented with B. subtilis strain 1781 747. Body weight gains of subtilis-supplemented diets were increased up 5.6% group 7.6% 747 compared diet. Compared controls, 83 metabolites altered (p < 0.05)...
Chicken NK-lysin peptide 2 (cNK-2) is a natural lytic with direct cytotoxicity against many apicomplexan parasites including Eimeria . Developing an effective oral delivery strategy to express cNK-2 in the intestine, where interact host's gut epithelial cells, may effectively reduce fecundity of and minimize intestinal damage. Furthermore, modulates immune responses decrease local inflammation elicited by infection intestine. Therefore, we developed stable strain Bacillus subtilis ( B. )...
A composite system with embedded bimodal-sized hybrid core–shell spheres is reported for electromagnetic interference (EMI) shielding applications, of which the shells are either wave-diffuse reflecting nickel/gold or wave-absorbing graphene.
A total of 144 pigs with 18.4 ± 2.3 kg initial body weight (BW) at 6 wk age were used in a 40-d trial to evaluate effects protease (300,000 U/kg feed, BioResource International Inc., Durham, NC, USA) on growth performance, apparent ileal digestibility (AID) nutrients, and gut health fed diets sorghum. Pigs randomly allotted 4 treatments (12 pens per treatment, 3 pen) 2 × factorial arrangement (corn or sorghum basal diets, 0 0.05% as factors) sex BW blocks. Experimental period had phase 1 (d...
This study was to investigate the effect of corn naturally contaminated with aflatoxins (AF) under regulatory level on growth performance and health nursery pigs, efficiency yeast cell wall based feed additive (YC) mainly composed β-glucans mannan oligosaccharide (MOS) (Integral A+, Alltech, Lexington, KY) in prevention mycotoxicosis. Pigs (60 barrows 60 gilts at 6.02 ± 0.83 kg BW) were randomly allotted 4 treatments a randomized complete block design 2 × factorial arrangement 10 pens (5...
Two studies were conducted to evaluate the effects of maltol as a postbiotic on innate immunity, gut health, and enteric infection. In first study, an in vitro culture system was used immune response chicken macrophage cells (CMC), integrity intestinal epithelial (IEC), anti-parasitic activity against Eimeria maxima , differentiation quail muscle (QMC) primary embryonic (PMC). All seeded 24-well plates treated with at concentrations 0.1, 1.0, 10.0 μg. CMC IEC stimulated by lipopolysaccharide...