A5041770051- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Complex Network Analysis Techniques
- Mental Health Research Topics
- HIV Research and Treatment
- Schizophrenia research and treatment
- Genomics and Phylogenetic Studies
- Hepatitis C virus research
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Hepatitis B Virus Studies
- Opinion Dynamics and Social Influence
- Liver Disease Diagnosis and Treatment
- HIV/AIDS Research and Interventions
- Bioinformatics and Genomic Networks
- Evolution and Genetic Dynamics
- HIV/AIDS drug development and treatment
- Tryptophan and brain disorders
- HIV, Drug Use, Sexual Risk
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Child and Adolescent Psychosocial and Emotional Development
- COVID-19 epidemiological studies
- Mathematical and Theoretical Epidemiology and Ecology Models
- Neurotransmitter Receptor Influence on Behavior
- Vestibular and auditory disorders
- Genetic Associations and Epidemiology
TechnoServe
2019
Health Net
2017
Max Planck Institute for Informatics
2010-2017
Max Planck Society
2011-2015
Azienda Ospedaliera Universitaria Pisana
2011
University of Oslo
2006-2010
Karolinska Institutet
2006-2008
KTH Royal Institute of Technology
2006
Individual variation is increasingly recognized as important to psychopathology research. Concurrently, new methods of analysis based on network models are bringing perspectives mental (dys)function. This current work analyzed idiographic multivariate time series data using a novel methodology that incorporates contemporaneous and lagged associations in mood anxiety symptomatology. Data were taken from 40 individuals with generalized disorder (GAD), major depressive (MDD), or comorbid GAD...
Viral sequence classification has wide applications in clinical, epidemiological, structural and functional categorization studies. Most existing approaches rely on an initial alignment step followed by based phylogenetic or statistical algorithms. Here we present ultrafast alignment-free subtyping tool for human immunodeficiency virus type one (HIV-1) adapted from Prediction Partial Matching compression. This tool, named COMET, was compared to the widely used phylogeny-based REGA SCUEAL...
Centrality measures such as the degree, k-shell, or eigenvalue centrality can identify a network's most influential nodes, but are rarely usefully accurate in quantifying spreading power of vast majority nodes which not highly influential. The all network is better explained by considering, from continuous-time epidemiological perspective, distribution force infection each node generates. resulting metric, \textit{expected force}, accurately quantifies under primary models across wide range...
Human immunodeficiency virus type 1 (HIV-1) was discovered in the early 1980s when had already established a pandemic. For at least three decades epidemic Western World has been dominated by subtype B infections, as part of sub-epidemic that traveled from Africa through Haiti to United States. However, pattern subsequent spread still remains poorly understood. Here we analyze large dataset globally representative HIV-1 strains map their around world over last 50 years and describe...
Abstract Background Relationships between cognitive deficits and brain morphological changes observed in schizophrenia are alternately explained by less gray matter the cerebral cortex, alterations neural circuitry involving basal ganglia, alteration cerebellar structures related circuitry. This work explored a model encompassing all of these possibilities to identify strongest relationships skill schizophrenia. Methods Seventy-one patients with sixty-five healthy control subjects were...
Massive growth in human mobility has dramatically increased the risk and rate of pandemic spread. Macro-level descriptors topology World Airline Network (WAN) explains middle late stage dynamics spread mediated by this network, but necessarily regard early variation as stochastic. We propose that much can be explained appropriately characterizing local network surrounding an outbreak's debut location.Based on a model WAN derived from public data, we measure for each airport expected force...
Recent research has emphasized rumination as an important maintaining factor in various mental disorders. However, operationalization and therefore induction of experimental settings poses a major challenge terms ecological validity. As stress seems to play key role everyday situations eliciting rumination, we conducted two paradigms while assessing behavioral neurophysiological measures. Aiming replicate previous findings on induced by means the Trier Social Stress Test (TSST) comparing...
Long-term amphetamine and methamphetamine dependence has been linked to cerebral blood perfusion, metabolic, white matter abnormalities. Several studies have abuse cortical grey reduction, though with divergent findings. Few publications investigate unmethylated amphetamine's potential effects on matter. This work investigated if dependent patients showed reduced thickness. Subjects were 40 subjects healthy controls. While all recruited be free of alcohol dependence, structured clinical...
Recent work showed an association of prefrontal dysfunctions in patients with Major Depressive Disorder (MDD) and social stress induced rumination. However, up to date it is unclear which etiological features MDD might cause dysfunctions. In the study at hand, we aimed replicate recent findings, that activation alterations during Trier Social Stress Test (TSST) subsequently increased stress-reactive rumination compared healthy controls. Moreover, explore role adverse childhood experiences...
Objective To investigate associations between brain-derived neurotrophic factor (BDNF) gene polymorphisms and regional frontal cortical thickness volume in patients with schizophrenia healthy control participants. Methods BDNF genotyping was performed using polymerase chain reaction pyrosequencing techniques 96 or schizoaffective disorder 104 Cortical morphology analyzed by processing magnetic resonance brain images the FreeSurfer software package. General linear model analysis used to study...
Abstract Background In order to investigate the relationship between stress-reactive rumination and implementation of different emotion-regulation strategies (ERS), pilot study at hand assessed ecological momentary assessment data twice per day from currently depressed patients (n = 21) healthy controls 23). Methods We analyzed differences in ERS (body-based, behavioral, cognitive, social multiple) occurrence stress, self-efficacy groups as well associations a given time-point later levels...
The hepatitis B virus (HBV) is classified into distinct genotypes A-H that are characterized by different progression of and sensitivity to interferon treatment. Previous computational genotyping methods not robust enough regarding HBV dual infections with genotypes. correct classification sequences the present impaired due multiple ambiguous sequence positions. We a model able identify genotype inter- intragenotype using population-based sequencing data. Model verification on synthetic data...
ABSTRACT Background and objective Exacerbations of chronic obstructive pulmonary disease (ECOPD) are associated with increased in‐hospital short‐term mortality. Developing an easy‐to‐use model to predict adverse outcomes will be useful in daily clinical practice facilitate management decisions. We aimed assess mortality rates potential predictors for after severe ECOPD. Classification Regression Tree (CART) was used identify outcome. Methods A retrospective observational cohort study,...
A number of different gene polymorphisms have been found to dispose for the development schizophrenia. However, no single polymorphism is sufficient precipitation Swedish psychosis patients (n=103) and control subjects (n=89) were analyzed 36 nucleotide in 30 candidate genes Evidence association was with Bayesian statistical methods. Variants coding dopamine-D2 receptor, brain-derived neurotrophic factor (BDNF), neuropeptide Y (NPY), neuregulin 1, reelin synapsin 3 showed schizophrenia,...
Genotype-derived drug resistance profiles are a valuable asset in HIV-1 therapy decisions. Therapy decisions could be further improved, both terms of predicting length current success and preserving followup options, through better knowledge mutational pathways- here defined as specific locations on the viral genome which, when mutant, alter risk that additional mutations arise. We limit search to reverse transcriptase region which host nucleoside (NRTI) non-nucleoside (NNRTI) inhibitors (as...
Cybersecurity is today's most pressing corporate governance issue, but one which Boards of Directors and senior management find challenging to manage. The concept cyber hygiene can define stress tests assess Cyber Value at Risk, helping companies manage risk as other macro-level business risks. be described the frequency cybersecurity related operational stoppages or disruptions time required resolve these issues when they occur. Hygiene also includes yield, efficiency a company's security...
In treating hepatitis B virus (HBV) and human immunodeficiency (HIV) infections, the rapid reselection of resistance-associated variants (RAVs) is well known in patients with repeated exposure to same class antiviral agents. For chronic C who have experienced virologic failure direct-acting drugs, potential for persistent RAVs unknown. Nine received 14 days telaprevir monotherapy were retreated telaprevir-based triple therapy 4.3 5.7 years later. four both telaprevir-containing regimens,...
Repetitive negative thinking (RNT), including rumination, plays a key role in various psychopathologies. Although several psychotherapeutic treatments have been developed to reduce RNT, the neural correlates of those specific and psychotherapy general are largely unknown. Functional near-infrared spectroscopy (fNIRS) offers potential investigate techniques situ. Therefore, this study we investigated efficacy fNIRS adapted Mindfulness-based Emotion Regulation Training (MBERT) for treatment...