A5060939036- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Gastroesophageal reflux and treatments
- Gastrointestinal motility and disorders
- Veterinary medicine and infectious diseases
- Gastrointestinal disorders and treatments
- Eosinophilic Esophagitis
- Gallbladder and Bile Duct Disorders
- Diet and metabolism studies
- Biochemical Analysis and Sensing Techniques
- Gut microbiota and health
- Gastrointestinal Bleeding Diagnosis and Treatment
- Skin Protection and Aging
- melanin and skin pigmentation
- Pancreatitis Pathology and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Infant Nutrition and Health
- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Gastrointestinal Tumor Research and Treatment
- Advanced Glycation End Products research
- Neurobiology and Insect Physiology Research
- Mycobacterium research and diagnosis
- Intestinal and Peritoneal Adhesions
- Neuroendocrine Tumor Research Advances
Severance Hospital
2023-2025
The Busan Metropolitan Simin Municipal Library
2025
Yonsei University
2023-2024
Korea Institute of Oriental Medicine
2021-2024
Eulji University
2021-2023
St. Vincent's Hospital
2013-2022
Korea University
2015-2022
Incheon National University
2022
Sookmyung Women's University
2022
Catholic University of Korea
2012-2021
Olfactory receptors (ORs) are present in tissues outside the olfactory system; however, function of these remains relatively unknown. Here, we determined that receptor 544 (Olfr544) is highly expressed liver and adipose tissue mice regulates cellular energy metabolism obesity. Azelaic acid (AzA), an Olfr544 ligand, specifically induced PKA-dependent lipolysis adipocytes promoted fatty oxidation (FAO) ketogenesis liver, thus shifting fuel preference to fats. After 6 weeks administration, fed...
Ulcerative colitis is an inflammatory bowel disease (IBD) with relapsing and remitting patterns, it caused by varied factors, such as the intestinal inflammation extent duration. We examined preventative effects of human milk oligosaccharides (HMOs) on epithelial barrier integrity in interleukin (IL)-6-induced cell model dextran sodium sulfate (DSS)-induced acute mouse model. HMOs including 2'-fucosyllactose (FL) 3-FL positive controls fructooligosaccharide (FOS) 5-acetylsalicylic acid...
This study developed a new method for forensic saliva identification using three oral bacteria, Streptococcus salivarius, sanguinis, and Neisseria subflava, combined with real-time polymerase chain reaction (RT-PCR) system we called OB mRT-PCR. Analytical sensitivity results showed that the target bacteria were amplified at 102-107 copies/reaction, analytical specificity was assessed 24 other viruses, protozoa. To evaluate mRT-PCR kit applications, from 140 Korean individuals tested, least...
Hyperlipidaemia is a major cause of atherosclerosis and related CVD can be prevented with natural substances. Previously, we reported that novel Bacillus-fermented green tea (FGT) exerts anti-obesity hypolipidaemic effects. This study further investigated the hypotriglyceridaemic anti-obesogenic effects FGT its underlying mechanisms. effectively inhibited pancreatic lipase activity in vitro (IC50, 0·48 mg/ml) ameliorated postprandial lipaemia rats (26 % reduction 500 mg/kg FGT). In...
Cyanidin-3-O-glucoside (C3G) is a natural anthocyanin abundant in fruits and vegetables that interacts possibly modulates energy metabolism oxidative stress. This study investigated the effect of C3G on gluconeogenesis cancer cell senescence. activates adenosine monophosphate-activated protein kinase (AMPK), cellular sensor involved aging process. suppressed hepatic by reducing expression gluconeogenic genes through phosphorylation inactivation CRTC2 HDAC5 coactivators via AMPK. did not...
Esophageal bezoars are known to be significantly rarer compared gastric bezoars. A 68-year-old woman presented with acute chest pain and worsening dysphagia both solids liquids, culminating in inability consume water without vomiting.
In the airline industry, customer satisfaction occurs when passengers’ expectations are met through experience. Considering that service quality is main factor in obtaining new and retaining existing customers, companies applying various approaches to improve of physical social servicescapes. It common use data analysis techniques for analyzing propensity marketing. However, their application industry has traditionally focused solely on surveys; hence, there a lack attention paid deep...
Lactase deficiency, which has many similarities with small intestinal bacterial overgrowth (SIBO), causes various gastrointestinal symptoms. We estimate the prevalence of SIBO in patients symptoms from dairy products and investigate association between lactase deficiency (LD) SIBO.This prospective study included functional product indigestion. A questionnaire on symptoms, a hydrogen (H2)-methane glucose breath test (GBT) for SIBO, lactose intolerance quick (LQT) LD using upper endoscopy were...
The relationship between polymorphisms in vascular endothelial growth factor (VEGF) and gastric cancer is still inconclusive. We investigated whether there an association VEGF genetic risk of cancer, evaluated the recurrence advanced after curative resection with adjuvant chemotherapy according to polymorphisms. functional single nucleotide (SNPs) gene (+936C > T, − 634G C, 2578C A, + 1612G A) were evaluated. Genotypes determined by polymerase chain reaction-restriction fragment length...
Immune checkpoints such as programmed death-1 (PD-1) have been proven antitumor targets by enhancing cytotoxic T cell activity. All immune checkpoint blockades are antibody therapeutics that large size and high affinity, well known immune-related side effects low responses. To overcome the limitation of therapeutics, we explored PD-1/PD-L1 (programmed death-ligand 1) in traditional oriental medicine, which has a long history but not yet studied blockades. Sanguisorbae Radix extract (SRE)...
The prevalence of ulcerative colitis (UC) has surged in Asian nations recently. limitations traditional drug treatments, including biologics, have spurred interest herbal medicines for managing UC. This study aimed to elucidate the protective mechanisms hydroethanolic extract from Lepidium apetalum Willdenow (LWE) on intestinal integrity and inflammation a dextran sodium sulfate (DSS)-induced model inflammatory bowel disease (IBD). Using UPLC-MS/MS analysis, eleven phytochemicals were...
Angiodysplasia is important in the differential diagnosis of upper gastrointestinal bleeding (UGIB), but clinical features and outcomes associated with UGIB from angiodysplasia have not been characterized. We aimed to analyze characteristics presented as UGIB.Between January 2004 December 2013, a consecutive series patients admitted were retrospectively analyzed. Thirty-five enrolled. compared them an asymptomatic control group (incidental finding health screening, n = 58) (simultaneous...
Abstract Background Addressing the increasing antibiotic resistance, including clarithromycin which affects Helicobacter pylori eradication therapy, is a challenge for clinicians. The objective of this study was to determine efficacy bismuth added standard triple therapy as first‐line treatment regimen infection. secondary outcome clarithromycin‐resistant strains. Material and Methods A prospective undertaken from January December 2019. total 107 patients with infection were enrolled...
We investigated the effects of BREs named Heukmi on osteogenic and adipogenic differentiation in C3H10T1/2 mesenchymal stem cells. stimulate osteogenesis, enhancing mRNA expression runt-related transcription factor 2 alkaline phosphatase (ALP), increasing ALP protein cellular enzyme activity, thus elevating intracellular calcium deposition. also suppressed adipogenesis by downregulating peroxisome proliferator-activated receptor-γ, C/EBPδ C/EBPα, major regulators adipogenesis. In cells...