A5058819375- Infective Endocarditis Diagnosis and Management
- Orthopedic Infections and Treatments
- Lymphoma Diagnosis and Treatment
- Respiratory viral infections research
- Autophagy in Disease and Therapy
- Chronic Lymphocytic Leukemia Research
- Heme Oxygenase-1 and Carbon Monoxide
- Social Media in Health Education
- Chromatin Remodeling and Cancer
- Pediatric health and respiratory diseases
- Radiology practices and education
- Antimicrobial Resistance in Staphylococcus
- Polyomavirus and related diseases
- Cardiac Valve Diseases and Treatments
- Acute Myeloid Leukemia Research
- Advanced X-ray and CT Imaging
- Biomedical and Engineering Education
- Soybean genetics and cultivation
- Phytase and its Applications
- Bacterial Identification and Susceptibility Testing
- Infectious Aortic and Vascular Conditions
- Artificial Intelligence in Healthcare and Education
- CAR-T cell therapy research
- Inflammasome and immune disorders
- Health Literacy and Information Accessibility
Cleveland Clinic
2024-2025
Michigan Medicine
2019-2022
University of Michigan
2012-2021
Cornell University Agricultural Experiment Station
2013
Cornell University
2013
Abstract Respiratory syncytial virus (RSV) is the major cause of lower respiratory tract infection in children worldwide. Sirtuin 1 (SIRT1), an NAD+-dependent deacetylase, has been associated with induction autophagy and regulation inflammatory mediators. We found that Sirt1 was upregulated mouse lung after RSV infection. Infected animals received EX-527, a selective SIRT1 inhibitor, displayed exacerbated pathology, increased mucus production, elevated viral load, enhanced Th2 cytokine...
Abstract High expression of MYC and its target genes identify germinal center B-cell diffuse large lymphomas (GCB-DLBCL) associated with poor outcomes. We used CRISPR-interference profiling human lymphoma cell lines to define essential enhancers in the locus non-immunoglobulin rearrangement partner loci, including a recurrent between BCL6 control region. GCB-DLBCL without are dependent on an evolutionarily-conserved enhancer we name “germinal 1” (GME-1), which is activated by transcription...
Abstract Sucrose, raffinose and stachyose accumulate as stored soluble carbohydrates in embryos during soybean [ Glycine max L. (Merrill)] seed development maturation. Raffinose feed products are not digested by humans, chickens or pigs, resulting flatulence reduced nutritional value. Soybean lines selected for low (LRS) raffinose, phytin (LRSP1, LRSP2) concentrations mature seeds were compared to a CHECK line with normal phytin. To determine whether increasing the supply of free cyclitols...
Abstract Respiratory syncytial virus (RSV) infection is the leading cause of lower respiratory tract in infants and children worldwide. Dendritic cells (DC) prime adaptive immune response by recognizing delivering viral antigens to local lymph nodes, presenting antigen T cells, displaying co-stimulatory markers, releasing cytokines. Recent studies have linked macroautophagy intracellular pathogen recognition activation DCs enhanced antigen-presenting cell (APC) function. SIRT1, a NAD+...
In Brief Introduction Cases of possible and/or culture-negative endocarditis continue to be a diagnostic challenge. Performing bacterial 16S ribosomal RNA polymerase chain reaction (16S rRNA PCR) sequencing on cardiac valves allows providers acquire microbiologic information that was previously unobtainable. However, few publications address how the (PCR) results impact clinical management in patients. Methods Between July 1, 2014, and December 31, 2018, we reviewed all PCR tests collected...
Abstract Background Cases of possible and/or culture-negative endocarditis continue to be a diagnostic challenge. Performing bacterial 16S ribosomal RNA polymerase chain reaction (rRNA PCR) sequencing on cardiac valves now allows providers make microbiologic diagnoses that were previously unobtainable (sensitivity 66–80.5%). However, few publications address how the PCR results impact clinical management in patients. Methods Between July 1, 2014 and December 31, 2018, all rRNA tests...
Abstract Background Care for patients with infectious endocarditis is complicated by delays in diagnosis and relatively low sensitivity of existing diagnostic algorithms, particularly the Duke Criteria. In recent years, cardiac positron emission tomography (PET) has been identified as a useful tool detecting occult endocardial infections. Multiple prospective studies have demonstrated that when incorporated conventional imaging modalities PET can improve Criteria 27–38 percent. These used...
Abstract Introduction/Objective First-year pathology residents begin their training with variable experience in anatomic pathology. At the University of Michigan, we have recently instated an introductory rotation (“Introduction to Surgical Pathology” [ISP]) all new prior core surgical rotations. Methods For first two weeks ISP, learn gross under supervision certified Pathologists’ Assistants. Residents biopsies gain familiarity dictation and grossing software learning how approach larger...