A5063108593- Chromatin Remodeling and Cancer
- Mechanisms of cancer metastasis
- Nuclear Receptors and Signaling
- Cutaneous lymphoproliferative disorders research
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- CAR-T cell therapy research
- Genomics and Chromatin Dynamics
- Cancer Mechanisms and Therapy
- COVID-19 and healthcare impacts
- Zoonotic diseases and public health
- Protein Degradation and Inhibitors
- Mosquito-borne diseases and control
- Chromosomal and Genetic Variations
- Polyomavirus and related diseases
- Viral-associated cancers and disorders
- Surgical site infection prevention
- T-cell and Retrovirus Studies
- Animal Genetics and Reproduction
- Antenna Design and Analysis
- Cancer Cells and Metastasis
- Economic and Financial Impacts of Cancer
- RNA Research and Splicing
- Heparin-Induced Thrombocytopenia and Thrombosis
- Fungal Infections and Studies
University of Michigan
2020-2025
Michigan United
2025
Michigan Medicine
2022
Segeberger Kliniken
2018
UNC Lineberger Comprehensive Cancer Center
2016-2018
University of North Carolina at Chapel Hill
2013-2017
Leipzig University
2013
SWI/SNF is a large heterogeneous multi-subunit chromatin remodeling complex. It consists of multiple sets mutually exclusive components. Understanding how loss one sibling pair affects the occupancy and function remaining complex needed to understand mutations in particular subunit might affect tumor formation. Recently, we showed that members ARID family subunits (ARID1A, ARID1B ARID2) had transcriptional relationships including both antagonism cooperativity. However, it remains unknown...
Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin cancer that frequently carries integrated polyomavirus (MCPyV) genome and expresses viral transforming antigens (TAgs). MCC tumor cells also express signature genes detected in skin-resident, postmitotic cells, including atonal bHLH transcription factor 1 (ATOH1), which required for development from epidermal progenitors. We now report the use of vivo cellular reprogramming, using ATOH1, to drive murine epidermis. generated...
The ability to faithfully transmit genetic information across generations via the germ cells is a critical aspect of mammalian reproduction. process cell development requires number large-scale modulations chromatin within nucleus. One such occasion arises during meiotic recombination, when hundreds DNA double-strand breaks are induced and subsequently repaired, enabling transfer between homologous chromosomes. inability properly repair damage known lead an arrest in developing sterility...
Neoplasms originating from thymic T-cell progenitors and post-thymic mature subsets account for a minority of lymphoproliferative neoplasms. These derived neoplasms, while molecularly genetically heterogeneous, exploit transcription factors signaling pathways that are critically important in normal biology, including those implicated antigen-, costimulatory-, cytokine-receptor signaling. The factor GATA-3 regulates the growth proliferation both immature T cells has recently been most common...
Abstract High expression of MYC and its target genes identify germinal center B-cell diffuse large lymphomas (GCB-DLBCL) associated with poor outcomes. We used CRISPR-interference profiling human lymphoma cell lines to define essential enhancers in the locus non-immunoglobulin rearrangement partner loci, including a recurrent between BCL6 control region. GCB-DLBCL without are dependent on an evolutionarily-conserved enhancer we name “germinal 1” (GME-1), which is activated by transcription...
Early detection of oral cancer is a major health issue. The objective this pilot study was to analyze the deformability healthy and cells using microfluidic optical stretcher (OS).Different cell lines, primary cells, their counterparts were cultivated characterized, respectively. A measurable deformation along axis detected, caused by surface stress, which optically induced laser power.All revealed viscoelastic extension behavior showed characteristic response under light exposure....
Abstract Chromatin remodeling and histone modifying enzymes play a critical role in shaping the regulatory output of cell. Although much is known about these classes proteins, identifying mechanisms by which they coordinate gene expression programs remains an exciting topic investigation. One factor that may contribute to targeting activity chromatin regulators local landscape. We leveraged genomic approaches publically-available datasets characterize landscape at targets human INO80 complex...
The DUSP22-IRF4 gene rearrangement results in downregulation of DUSP22, a presumed tumor suppressor T-cell lymphomagenesis. It has been described some cases primary cutaneous and systemic anaplastic large-cell lymphoma, lymphomatoid papulosis, transformed mycosis fungoides. Here we describe two patients with clinical lesions resembling patch/plaque fungoides that did not meet WHO criteria for transformation on histopathology yet showed DUSP22 translocation. One patient who had history...
High expression of MYC and its target genes define a subset germinal center B-cell diffuse large lymphoma (GCB-DLBCL) associated with poor outcomes. Half these high-grade cases show chromosomal rearrangements between the locus heterologous enhancer-bearing loci, while focal deletions adjacent non-coding gene PVT1 are enriched in -intact cases. To identify genomic drivers activation, we used high-throughput CRISPR-interference (CRISPRi) profiling candidate enhancers rearrangement partner loci...
Type I cryoglobulinemic vasculitis (CryoVas) is a rare entity occurring in the context of an existing lymphoproliferative disorder and often exhibiting severe cutaneous involvement.1 Cutaneous clinical manifestations include palpable purpura with necrosis ulceration. Importantly, few reports CryoVas exist literature, characteristic histopathologic features are not well-characterized. Herein, we present case recurrent setting multiple myeloma.
Abstract Background SWI/SNF is a large heterogenous multi-subunit chromatin remodeling complex. It consists of multiple sets mutually exclusive components. Understanding how loss one sibling pair affects the occupancy and function remaining complex needed to understand mutations in particular subunit might affect tumor formation. Recently, we showed that members ARID family subunits (ARID1A, ARID1B, ARID2) had transcriptional relationships including both antagonism cooperativity. However, it...
Yellow fever terrorized communities in tropical and urban settings during its height the nineteenth-century American south. Carried by Aedes aegypti mosquitoes, which breed stagnant water, virus infects humans fervently is most known for symptoms of jaundice vomito negro, a dark vomit coagulated blood. During near-annual outbreaks yellow fever, caregivers struggled to cope with emotional consequences failing medicine, sometimes leaving behind clues their confusion treating disease offering...